Spongious fillers based on collagen-hydroxyapatite-eugenol acetate with therapeutic potential in bone cancer

Alina F. Vladu; Stefania Marin; Ionela A. Neacșu; Roxana D. Truşcă; Mădălina G. Albu Kaya; Durmus A. Kaya; Ana Maria Popa; Cătălina Poiană; Ioan Cristescu; Cristina Orlov; Denisa Ficai; Anton Ficai; Denisa I. Udeanu; Bruno Ștefan Velescu; Taxiarchis Konstantinos Nikolouzakis; Leonid Gurevich; Andrey N. Kuskov; Cornelia Nițipir

doi:10.31925/farmacia.2020.2.17

Spongious fillers based on collagen-hydroxyapatite-eugenol acetate with therapeutic potential in bone cancer

Alina F. Vladu, Stefania Marin, Ionela A. Neacșu, Roxana D. Truşcă, Mădălina G. Albu Kaya, Durmus A. Kaya, Ana Maria Popa, Cătălina Poiană, Ioan Cristescu^*, Cristina Orlov, Denisa Ficai, Anton Ficai, Denisa I. Udeanu, Bruno Ștefan Velescu, Taxiarchis Konstantinos Nikolouzakis, Leonid Gurevich, Andrey N. Kuskov, Cornelia Nițipir

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

Abstract

The aim of this study was to develop and characterize composite materials based on collagen, hydroxyapatite and eugenol acetate as new filler biomaterial for the reconstruction of the tissue damage arising after the resection in case of bone cancer. Composite gels consisting of collagen and hydroxyapatite in different proportions (Coll:HAp-100:0; 70:30; 40:60-w/w) and 0.5% eugenol acetate were lyophilized and spongious fillers were obtained. The fillers were characterized by water absorption, enzymatic degradation and examined by optical and scanning electron microscopy, EDS, FT-IR spectroscopy while eugenol acetate release from the compositions was also studied. The results showed that the filler with optimal composition (Coll-HAp-40:60 w/w) completely degrade over about 48 hours, the release capacity being longer during the 144 hours. The complex results obtained from physical-chemical, morphological and eugenol acetate release profile evaluation for the designed composite materials based on collagen and hydroxyapatite testify these formulations as drug delivery systems with potential applications as fillers in orthopaedic field in bone cancer.

Original language	English
Journal	Farmacia
Volume	68
Issue number	2
Pages (from-to)	313-321
Number of pages	9
ISSN	0014-8237
DOIs	https://doi.org/10.31925/farmacia.2020.2.17
Publication status	Published - 17 Feb 2020

Bibliographical note

Publisher Copyright:
© 2020, Romanian Society for Pharmaceutical Sciences. All rights reserved.

Keywords

Bone cancer
Collagen
Eugenol acetate
Fillers
Hydroxyapatite

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10.31925/farmacia.2020.2.17

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Vladu, A. F., Marin, S., Neacșu, I. A., Truşcă, R. D., Albu Kaya, M. G., Kaya, D. A., Popa, A. M., Poiană, C., Cristescu, I., Orlov, C., Ficai, D., Ficai, A., Udeanu, D. I., Velescu, B. Ș., Nikolouzakis, T. K., Gurevich, L., Kuskov, A. N., & Nițipir, C. (2020). Spongious fillers based on collagen-hydroxyapatite-eugenol acetate with therapeutic potential in bone cancer. Farmacia, 68(2), 313-321. https://doi.org/10.31925/farmacia.2020.2.17

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title = "Spongious fillers based on collagen-hydroxyapatite-eugenol acetate with therapeutic potential in bone cancer",

abstract = "The aim of this study was to develop and characterize composite materials based on collagen, hydroxyapatite and eugenol acetate as new filler biomaterial for the reconstruction of the tissue damage arising after the resection in case of bone cancer. Composite gels consisting of collagen and hydroxyapatite in different proportions (Coll:HAp-100:0; 70:30; 40:60-w/w) and 0.5% eugenol acetate were lyophilized and spongious fillers were obtained. The fillers were characterized by water absorption, enzymatic degradation and examined by optical and scanning electron microscopy, EDS, FT-IR spectroscopy while eugenol acetate release from the compositions was also studied. The results showed that the filler with optimal composition (Coll-HAp-40:60 w/w) completely degrade over about 48 hours, the release capacity being longer during the 144 hours. The complex results obtained from physical-chemical, morphological and eugenol acetate release profile evaluation for the designed composite materials based on collagen and hydroxyapatite testify these formulations as drug delivery systems with potential applications as fillers in orthopaedic field in bone cancer.",

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year = "2020",

month = feb,

day = "17",

doi = "10.31925/farmacia.2020.2.17",

language = "English",

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Vladu, AF, Marin, S, Neacșu, IA, Truşcă, RD, Albu Kaya, MG, Kaya, DA, Popa, AM, Poiană, C, Cristescu, I, Orlov, C, Ficai, D, Ficai, A, Udeanu, DI, Velescu, BȘ, Nikolouzakis, TK, Gurevich, L, Kuskov, AN & Nițipir, C 2020, 'Spongious fillers based on collagen-hydroxyapatite-eugenol acetate with therapeutic potential in bone cancer', Farmacia, vol. 68, no. 2, pp. 313-321. https://doi.org/10.31925/farmacia.2020.2.17

TY - JOUR

T1 - Spongious fillers based on collagen-hydroxyapatite-eugenol acetate with therapeutic potential in bone cancer

AU - Vladu, Alina F.

AU - Marin, Stefania

AU - Neacșu, Ionela A.

AU - Truşcă, Roxana D.

AU - Albu Kaya, Mădălina G.

AU - Kaya, Durmus A.

AU - Popa, Ana Maria

AU - Poiană, Cătălina

AU - Cristescu, Ioan

AU - Orlov, Cristina

AU - Ficai, Denisa

AU - Ficai, Anton

AU - Udeanu, Denisa I.

AU - Velescu, Bruno Ștefan

AU - Nikolouzakis, Taxiarchis Konstantinos

AU - Gurevich, Leonid

AU - Kuskov, Andrey N.

AU - Nițipir, Cornelia

PY - 2020/2/17

Y1 - 2020/2/17

N2 - The aim of this study was to develop and characterize composite materials based on collagen, hydroxyapatite and eugenol acetate as new filler biomaterial for the reconstruction of the tissue damage arising after the resection in case of bone cancer. Composite gels consisting of collagen and hydroxyapatite in different proportions (Coll:HAp-100:0; 70:30; 40:60-w/w) and 0.5% eugenol acetate were lyophilized and spongious fillers were obtained. The fillers were characterized by water absorption, enzymatic degradation and examined by optical and scanning electron microscopy, EDS, FT-IR spectroscopy while eugenol acetate release from the compositions was also studied. The results showed that the filler with optimal composition (Coll-HAp-40:60 w/w) completely degrade over about 48 hours, the release capacity being longer during the 144 hours. The complex results obtained from physical-chemical, morphological and eugenol acetate release profile evaluation for the designed composite materials based on collagen and hydroxyapatite testify these formulations as drug delivery systems with potential applications as fillers in orthopaedic field in bone cancer.

AB - The aim of this study was to develop and characterize composite materials based on collagen, hydroxyapatite and eugenol acetate as new filler biomaterial for the reconstruction of the tissue damage arising after the resection in case of bone cancer. Composite gels consisting of collagen and hydroxyapatite in different proportions (Coll:HAp-100:0; 70:30; 40:60-w/w) and 0.5% eugenol acetate were lyophilized and spongious fillers were obtained. The fillers were characterized by water absorption, enzymatic degradation and examined by optical and scanning electron microscopy, EDS, FT-IR spectroscopy while eugenol acetate release from the compositions was also studied. The results showed that the filler with optimal composition (Coll-HAp-40:60 w/w) completely degrade over about 48 hours, the release capacity being longer during the 144 hours. The complex results obtained from physical-chemical, morphological and eugenol acetate release profile evaluation for the designed composite materials based on collagen and hydroxyapatite testify these formulations as drug delivery systems with potential applications as fillers in orthopaedic field in bone cancer.

KW - Bone cancer

KW - Collagen

KW - Eugenol acetate

KW - Fillers

KW - Hydroxyapatite

UR - http://www.scopus.com/inward/record.url?scp=85090722044&partnerID=8YFLogxK

U2 - 10.31925/farmacia.2020.2.17

DO - 10.31925/farmacia.2020.2.17

M3 - Journal article

AN - SCOPUS:85090722044

SN - 0014-8237

VL - 68

SP - 313

EP - 321

JO - Farmacia

JF - Farmacia

IS - 2

ER -

Spongious fillers based on collagen-hydroxyapatite-eugenol acetate with therapeutic potential in bone cancer

Abstract

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Keywords

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