State Space Temporal Gaussian Processes for Glucose Measurements

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Abstract

Measuring the blood glucose (BG) concentrations for people with diabetes is essential to achieve a better glycemic control either by medical professionals or by using feedback control algorithms. Continuous Glucose Monitoring (CGM) devices provide indirect measurements of the BG each I-S minutes. However, CGM devices suffer from correlated measurement errors and calibration errors. Detailed models for the errors of CGM devices already exist in the literature. Nonetheless, the identification of these models requires data from multiple CGM devices at once and accurate reference blood glucose measurements obtained clinically. This fact makes these models difficult to be subject-specific during typical treatment since diabetic subjects only use one CGM device with 3-4 finger pricking blood glucose measurements per day. In this paper, a methodology to obtain subject-specific CGM error models using Temporal Gaussian Processes (TGP) in their state space form is introduced. Three different TGPs are proposed and a strategy based on a particle Markov Chain Monte Carlo (MCMC) is used to perform regression and fit parameters for the models. The strategy is tested against data generated from virtual subject using detailed CGM error measurement models which were fitted with more than one CGM device and detailed clinical data from the literature. The results demonstrated the ability for TGP models with the proposed particle MCMC strategy to obtain subject-specific CGM error models using data available during the typical life of diabetic subjects.

Original languageEnglish
Title of host publication2022 European Control Conference (ECC)
Number of pages7
PublisherIEEE
Publication date2022
Pages284-290
Article number9838040
ISBN (Print)978-1-6654-9733-6
ISBN (Electronic)978-3-9071-4407-7
DOIs
Publication statusPublished - 2022
Event2022 European Control Conference (ECC) - London, United Kingdom
Duration: 12 Jul 202215 Jul 2022

Conference

Conference2022 European Control Conference (ECC)
Country/TerritoryUnited Kingdom
CityLondon
Period12/07/202215/07/2022

Keywords

  • glucose monitoring systems
  • Gaussian Processes
  • Particle filtering

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