TY - JOUR
T1 - Stringent or nonstringent complete remission and prognosis in acute myeloid leukemia
T2 - a Danish population-based study
AU - Øvlisen, Andreas K
AU - Oest, Anders
AU - Bendtsen, Mette D
AU - Bæch, John
AU - Johansen, Preben
AU - Lynggaard, Line S
AU - Mølle, Ingolf
AU - Mortensen, Thomas B
AU - Weber, Duruta
AU - Ertner, Gideon
AU - Schöllkopf, Claudia
AU - Thomassen, Jesper Q
AU - Nielsen, Ove Juul
AU - Østgård, Lene Sofie Granfeldt
AU - Bøgsted, Martin
AU - Dybkær, Karen
AU - Johnsen, Hans E
AU - Severinsen, Marianne T
N1 - © 2018 by The American Society of Hematology.
PY - 2018
Y1 - 2018
N2 - Stringent complete remission (sCR) of acute myeloid leukemia is defined as normal hematopoiesis after therapy. Less sCR, including non-sCR, was introduced as insufficient blood platelet, neutrophil, or erythrocyte recovery. These latter characteristics were defined retrospectively as postremission transfusion dependency and were suggested to be of prognostic value. In the present report, we evaluated the prognostic impact of achieving sCR and non-sCR in the Danish National Acute Leukaemia Registry, including 769 patients registered with classical CR (ie, <5% blasts in the postinduction bone marrow analysis). Individual patients were classified as having sCR (n = 360; 46.8%) or non-sCR (n = 409; 53.2%) based on data from our national laboratory and transfusion databases. Survival analysis revealed that patients achieving sCR had superior overall survival (hazard ratio [HR], 1.34; 95% confidence interval [CI], 1.10-1.64) as well as relapse-free survival (HR, 1.25; 95% CI, 1.03-1.51) compared with those with non-sCR after adjusting for covariates. Cox regression analysis regarding the impact of the stringent criteria for blood cell recovery identified these as significant and independent variables. In conclusion, this real-life register study supports the international criteria for response evaluation on prognosis and, most importantly, documents each of the 3 lineage recovery criteria as contributing independently.
AB - Stringent complete remission (sCR) of acute myeloid leukemia is defined as normal hematopoiesis after therapy. Less sCR, including non-sCR, was introduced as insufficient blood platelet, neutrophil, or erythrocyte recovery. These latter characteristics were defined retrospectively as postremission transfusion dependency and were suggested to be of prognostic value. In the present report, we evaluated the prognostic impact of achieving sCR and non-sCR in the Danish National Acute Leukaemia Registry, including 769 patients registered with classical CR (ie, <5% blasts in the postinduction bone marrow analysis). Individual patients were classified as having sCR (n = 360; 46.8%) or non-sCR (n = 409; 53.2%) based on data from our national laboratory and transfusion databases. Survival analysis revealed that patients achieving sCR had superior overall survival (hazard ratio [HR], 1.34; 95% confidence interval [CI], 1.10-1.64) as well as relapse-free survival (HR, 1.25; 95% CI, 1.03-1.51) compared with those with non-sCR after adjusting for covariates. Cox regression analysis regarding the impact of the stringent criteria for blood cell recovery identified these as significant and independent variables. In conclusion, this real-life register study supports the international criteria for response evaluation on prognosis and, most importantly, documents each of the 3 lineage recovery criteria as contributing independently.
U2 - 10.1182/bloodadvances.2017007393
DO - 10.1182/bloodadvances.2017007393
M3 - Journal article
C2 - 29523528
SN - 2473-9529
VL - 2
SP - 559
EP - 564
JO - Blood advances
JF - Blood advances
IS - 5
ER -