Structural and spectroscopic features of lutein/butanoyl-β-cyclodextrin nanoassemblies

R. Stancanelli, L.D. Løjkner, Kim Lambertsen Larsen, M. Guardo, C. Cannavà, S. Tommasini, C.A. Ventura, M.L. Calabrò, N. Micali, V. Villari, A. Mazzaglia

Research output: Contribution to journalJournal articleResearchpeer-review

19 Citations (Scopus)


Lutein, the primary carotenoid present in the central area of the retina of eye appears to be associated with the protection against age-related macular degeneration (the leading cause of blindness in older adults). Its lipophilicity and consequently its scarce water solubility (1.3×10 M) represent a drawback for bioavailability. To circumvent these unfavorable characteristics, in this work lutein (Lut) have been encapsulated in amphiphilic cyclodextrin (ACyD) by following the well-established strategy of entrapping a lipophilic drug in CyD carriers. Primary face butyrate modified β-cyclodextrins (C ) form in water nanoaggregates with a average size of 250nm and a ζ-potential of about -6mV. They are able to entrap lutein at 1:6 Lut/ACyD molar ratio by yielding nanoassemblies of vesicular aspect (320nm and -8mV) such as observed by static, dynamic and electrophoretic light-scattering. UV-vis measurements revealed that electronic properties of lutein were maintained when interact with ACyD nanoaggregates. The monitoring of the entapped carotenoid leaking from ACyD nanostructures was investigated suggesting the potential of Lut/ACyD nanoassemblies in drug delivery.
Original languageEnglish
JournalJournal of Pharmaceutical and Biomedical Analysis
Pages (from-to)214-218
Number of pages5
Publication statusPublished - 1 Dec 2012


Dive into the research topics of 'Structural and spectroscopic features of lutein/butanoyl-β-cyclodextrin nanoassemblies'. Together they form a unique fingerprint.

Cite this