Abstract
Some data have demonstrated a substantial subdermal accumulation of topically applied drugs in animals. The aim of this study was to evaluate a possible effect of epicutaneously applied clobetasol propionate on blood flow in human subcutaneous adipose tissue. Nine healthy subjects were studied. The 133Xenon wash-out method was used for the measurement of subcutaneous blood flow. Resting blood flow and the local blood flow regulatory mechanisms, autoregulation of blood flow and the veno-arteriolar reflex, were assessed prior to treatment and were measured following 24, 48 and 72 h of treatment. The results demonstrated no effect of clobetasol propionate on resting subcutaneous blood flow or the local regulatory mechanisms.
Original language | English |
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Journal | Journal of Dermatological Science |
Volume | 3 |
Issue number | 1 |
Pages (from-to) | 42-5 |
Number of pages | 4 |
ISSN | 0923-1811 |
DOIs | |
Publication status | Published - Jan 1992 |
Externally published | Yes |