Subsequent Event Risk in Individuals with Established Coronary Heart Disease: Design and Rationale of the GENIUS-CHD Consortium

Riyaz Patel; Vinicius Tragante; Amand F Schmidt; Raymond O McCubrey; Michael V Holmes; Laurence J Howe; Kenan Direk; Axel Åkerblom; Karin Leander; Salim S Virani; Karol A Kaminski; Jochen D Muehlschlegel; Hooman Allayee; Peter Almgren; Maris Alver; Ekaterina V Baranova; Hassan Behlouli; Bram Boeckx; Peter S Braund; Lutz P Breitling; Graciela Delgado; Nubia E Duarte; Marie-Pierre Dubé; Line Dufresne; Niclas Eriksson; Luisa Foco; Markus Scholz; Crystel M Gijsberts; Charlotte Glinge; Yan Gong; Jaana Hartiala; Mahyar Heydarpour; Jaroslav A Hubacek; Marcus Kleber; Daniel Kofink; Salma Kotti; Pekka Kuukasjärvi; Vei-Vei Lee; Andreas Leiherer; Petra A Lenzini; Daniel Levin; Leo-Pekka Lyytikäinen; Nicola Martinelli; Ute Mons; Christopher P Nelson; Kjell Nikus; Anna P Pilbrow; Rafal Ploski; Yan V Sun; Michael W T Tanck; W H Wilson Tang; Stella Trompet; Sander W van der Laan; Jessica Van Setten; Ragnar O Vilmundarson; Chiara Viviani Anselmi; Efthymia Vlachopoulou; Lawien Al Ali; Eric Boerwinkle; Carlo Briguori; John F Carlquist; Kathryn F Carruthers; Gavino Casu; John Deanfield; Panos Deloukas; Frank Dudbridge; Thomas Engström; Natalie Fitzpatrick; Kim Fox; Bruna Gigante; Stefan James; Marja-Liisa Lokki; Paulo A Lotufo; Nicola Marziliano; Ify R Mordi; Joseph B Muhlestein; Christopher Newton-Cheh; Jan Pitha; Christoph H Saely; Ayman Samman-Tahhan; Pratik B Sandesara; Andrej Teren; Adam Timmis; Frans Van de Werf; Els Wauters; Arthur A M Wilde; Ian Ford; David J Stott; Ale Algra; Maria G Andreassi; Diego Ardissino; Benoit J Arsenault; Christie M Ballantyne; Thomas O Bergmeijer; Connie R Bezzina; Simon C Body; Eric H Boersma; Peter Bogaty; Michiel Bots; Hermann Brenner; Jasper J Brugts; Ralph Burkhardt; Clara Carpeggiani; Gianluigi Condorelli; Rhonda M Cooper-DeHoff; Sharon Cresci; Nicolas Danchin; Ulf de Faire; Robert N Doughty; Heinz Drexel; James C Engert; Keith A A Fox; Domenico Girelli; Diederick E Grobbee; Emil Hagström; Stanley L Hazen; Claes Held; Harry Hemingway; Imo E Hoefer; G Kees Hovingh; Reza Jabbari; Julie A Johnson; J Wouter Jukema; Marcin P Kaczor; Mika Kähönen; Jiri Kettner; Marek Kiliszek; Olaf H Klungel; Bo Lagerqvist; Diether Lambrechts; Jari O Laurikka; Terho Lehtimäki; Daniel Lindholm; B K Mahmoodi; Anke H Maitland-van der Zee; Ruth McPherson; Olle Melander; Andres Metspalu; Anna Niemcunowicz-Janica; Oliviero Olivieri; Grzegorz Opolski; Colin N Palmer; Gerard Pasterkamp; Carl J Pepine; Alexandre C Pereira; Louise Pilote; Arshed A Quyyumi; A Mark Richards; Marek Sanak; Agneta Siegbahn; Tabassome Simon; Juha Sinisalo; J Gustav Smith; John A Spertus; Steen Stender; Alexandre F R Stewart; Wojciech Szczeklik; Anna Szpakowicz; Jean-Claude Tardif; Jurriën M Ten Berg; Jacob Tfelt-Hansen; George Thanassoulis; Joachim Thiery; Christian Torp-Pedersen; Yolanda van der Graaf; Frank L J Visseren; Johannes Waltenberger; Peter E Weeke; Pim Van der Harst; Chim C Lang; Naveed Sattar; Vicky A Cameron; Jeffrey L Anderson; James M Brophy; Guillaume Paré; Benjamin D Horne; Winfried März; Lars Wallentin; Nilesh J Samani; Aroon D Hingorani; Folkert W Asselbergs

doi:10.1161/CIRCGEN.119.002470

Subsequent Event Risk in Individuals with Established Coronary Heart Disease: Design and Rationale of the GENIUS-CHD Consortium

Riyaz Patel, Vinicius Tragante, Amand F Schmidt, Raymond O McCubrey, Michael V Holmes, Laurence J Howe, Kenan Direk, Axel Åkerblom, Karin Leander, Salim S Virani, Karol A Kaminski, Jochen D Muehlschlegel, Hooman Allayee, Peter Almgren, Maris Alver, Ekaterina V Baranova, Hassan Behlouli, Bram Boeckx, Peter S Braund, Lutz P BreitlingGraciela Delgado, Nubia E Duarte, Marie-Pierre Dubé, Line Dufresne, Niclas Eriksson, Luisa Foco, Markus Scholz, Crystel M Gijsberts, Charlotte Glinge, Yan Gong, Jaana Hartiala, Mahyar Heydarpour, Jaroslav A Hubacek, Marcus Kleber, Daniel Kofink, Salma Kotti, Pekka Kuukasjärvi, Vei-Vei Lee, Andreas Leiherer, Petra A Lenzini, Daniel Levin, Leo-Pekka Lyytikäinen, Nicola Martinelli, Ute Mons, Christopher P Nelson, Kjell Nikus, Anna P Pilbrow, Rafal Ploski, Yan V Sun, Michael W T Tanck, W H Wilson Tang, Stella Trompet, Sander W van der Laan, Jessica Van Setten, Ragnar O Vilmundarson, Chiara Viviani Anselmi, Efthymia Vlachopoulou, Lawien Al Ali, Eric Boerwinkle, Carlo Briguori, John F Carlquist, Kathryn F Carruthers, Gavino Casu, John Deanfield, Panos Deloukas, Frank Dudbridge, Thomas Engström, Natalie Fitzpatrick, Kim Fox, Bruna Gigante, Stefan James, Marja-Liisa Lokki, Paulo A Lotufo, Nicola Marziliano, Ify R Mordi, Joseph B Muhlestein, Christopher Newton-Cheh, Jan Pitha, Christoph H Saely, Ayman Samman-Tahhan, Pratik B Sandesara, Andrej Teren, Adam Timmis, Frans Van de Werf, Els Wauters, Arthur A M Wilde, Ian Ford, David J Stott, Ale Algra, Maria G Andreassi, Diego Ardissino, Benoit J Arsenault, Christie M Ballantyne, Thomas O Bergmeijer, Connie R Bezzina, Simon C Body, Eric H Boersma, Peter Bogaty, Michiel Bots, Hermann Brenner, Jasper J Brugts, Ralph Burkhardt, Clara Carpeggiani, Gianluigi Condorelli, Rhonda M Cooper-DeHoff, Sharon Cresci, Nicolas Danchin, Ulf de Faire, Robert N Doughty, Heinz Drexel, James C Engert, Keith A A Fox, Domenico Girelli, Diederick E Grobbee, Emil Hagström, Stanley L Hazen, Claes Held, Harry Hemingway, Imo E Hoefer, G Kees Hovingh, Reza Jabbari, Julie A Johnson, J Wouter Jukema, Marcin P Kaczor, Mika Kähönen, Jiri Kettner, Marek Kiliszek, Olaf H Klungel, Bo Lagerqvist, Diether Lambrechts, Jari O Laurikka, Terho Lehtimäki, Daniel Lindholm, B K Mahmoodi, Anke H Maitland-van der Zee, Ruth McPherson, Olle Melander, Andres Metspalu, Anna Niemcunowicz-Janica, Oliviero Olivieri, Grzegorz Opolski, Colin N Palmer, Gerard Pasterkamp, Carl J Pepine, Alexandre C Pereira, Louise Pilote, Arshed A Quyyumi, A Mark Richards, Marek Sanak, Agneta Siegbahn, Tabassome Simon, Juha Sinisalo, J Gustav Smith, John A Spertus, Steen Stender, Alexandre F R Stewart, Wojciech Szczeklik, Anna Szpakowicz, Jean-Claude Tardif, Jurriën M Ten Berg, Jacob Tfelt-Hansen, George Thanassoulis, Joachim Thiery, Christian Torp-Pedersen, Yolanda van der Graaf, Frank L J Visseren, Johannes Waltenberger, Peter E Weeke, Pim Van der Harst, Chim C Lang, Naveed Sattar, Vicky A Cameron, Jeffrey L Anderson, James M Brophy, Guillaume Paré, Benjamin D Horne, Winfried März, Lars Wallentin, Nilesh J Samani, Aroon D Hingorani, Folkert W Asselbergs

Research output: Contribution to journal › Journal article › Research › peer-review

18 Citations (Scopus)

165 Downloads (Pure)

Abstract

BACKGROUND: The Genetics of Subsequent Coronary Heart Disease (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events, in individuals with established CHD.

METHODS: The consortium currently includes 57 studies from 18 countries, recruiting 185 614 participants with either acute coronary syndrome, stable CHD, or a mixture of both at baseline. All studies collected biological samples and followed-up study participants prospectively for subsequent events.

RESULTS: Enrollment into the individual studies took place between 1985 to present day with a duration of follow-up ranging from 9 months to 15 years. Within each study, participants with CHD are predominantly of self-reported European descent (38%-100%), mostly male (44%-91%) with mean ages at recruitment ranging from 40 to 75 years. Initial feasibility analyses, using a federated analysis approach, yielded expected associations between age (hazard ratio, 1.15; 95% CI, 1.14-1.16) per 5-year increase, male sex (hazard ratio, 1.17; 95% CI, 1.13-1.21) and smoking (hazard ratio, 1.43; 95% CI, 1.35-1.51) with risk of subsequent CHD death or myocardial infarction and differing associations with other individual and composite cardiovascular endpoints.

CONCLUSIONS: GENIUS-CHD is a global collaboration seeking to elucidate genetic and nongenetic determinants of subsequent event risk in individuals with established CHD, to improve residual risk prediction and identify novel drug targets for secondary prevention. Initial analyses demonstrate the feasibility and reliability of a federated analysis approach. The consortium now plans to initiate and test novel hypotheses as well as supporting replication and validation analyses for other investigators.

Original language	English
Journal	CIRCULATION-GENOMIC AND PRECISION MEDICINE
Volume	12
Issue number	4
Pages (from-to)	145-160
ISSN	2574-8300
DOIs	https://doi.org/10.1161/CIRCGEN.119.002470
Publication status	Published - Apr 2019

Keywords

coronary artery disease
genetics
myocardial infarction
prognosis
secondary prevention

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Patel, R., Tragante, V., Schmidt, A. F., McCubrey, R. O., Holmes, M. V., Howe, L. J., Direk, K., Åkerblom, A., Leander, K., Virani, S. S., Kaminski, K. A., Muehlschlegel, J. D., Allayee, H., Almgren, P., Alver, M., Baranova, E. V., Behlouli, H., Boeckx, B., Braund, P. S., ... Asselbergs, F. W. (2019). Subsequent Event Risk in Individuals with Established Coronary Heart Disease: Design and Rationale of the GENIUS-CHD Consortium. CIRCULATION-GENOMIC AND PRECISION MEDICINE, 12(4), 145-160. https://doi.org/10.1161/CIRCGEN.119.002470

@article{fd5e019d7ce74733af0da46a4d1a5d57,

title = "Subsequent Event Risk in Individuals with Established Coronary Heart Disease: Design and Rationale of the GENIUS-CHD Consortium",

abstract = "BACKGROUND: The Genetics of Subsequent Coronary Heart Disease (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events, in individuals with established CHD.METHODS: The consortium currently includes 57 studies from 18 countries, recruiting 185 614 participants with either acute coronary syndrome, stable CHD, or a mixture of both at baseline. All studies collected biological samples and followed-up study participants prospectively for subsequent events.RESULTS: Enrollment into the individual studies took place between 1985 to present day with a duration of follow-up ranging from 9 months to 15 years. Within each study, participants with CHD are predominantly of self-reported European descent (38%-100%), mostly male (44%-91%) with mean ages at recruitment ranging from 40 to 75 years. Initial feasibility analyses, using a federated analysis approach, yielded expected associations between age (hazard ratio, 1.15; 95% CI, 1.14-1.16) per 5-year increase, male sex (hazard ratio, 1.17; 95% CI, 1.13-1.21) and smoking (hazard ratio, 1.43; 95% CI, 1.35-1.51) with risk of subsequent CHD death or myocardial infarction and differing associations with other individual and composite cardiovascular endpoints.CONCLUSIONS: GENIUS-CHD is a global collaboration seeking to elucidate genetic and nongenetic determinants of subsequent event risk in individuals with established CHD, to improve residual risk prediction and identify novel drug targets for secondary prevention. Initial analyses demonstrate the feasibility and reliability of a federated analysis approach. The consortium now plans to initiate and test novel hypotheses as well as supporting replication and validation analyses for other investigators.",

keywords = "coronary artery disease, genetics, myocardial infarction, prognosis, secondary prevention",

author = "Riyaz Patel and Vinicius Tragante and Schmidt, {Amand F} and McCubrey, {Raymond O} and Holmes, {Michael V} and Howe, {Laurence J} and Kenan Direk and Axel {\AA}kerblom and Karin Leander and Virani, {Salim S} and Kaminski, {Karol A} and Muehlschlegel, {Jochen D} and Hooman Allayee and Peter Almgren and Maris Alver and Baranova, {Ekaterina V} and Hassan Behlouli and Bram Boeckx and Braund, {Peter S} and Breitling, {Lutz P} and Graciela Delgado and Duarte, {Nubia E} and Marie-Pierre Dub{\'e} and Line Dufresne and Niclas Eriksson and Luisa Foco and Markus Scholz and Gijsberts, {Crystel M} and Charlotte Glinge and Yan Gong and Jaana Hartiala and Mahyar Heydarpour and Hubacek, {Jaroslav A} and Marcus Kleber and Daniel Kofink and Salma Kotti and Pekka Kuukasj{\"a}rvi and Vei-Vei Lee and Andreas Leiherer and Lenzini, {Petra A} and Daniel Levin and Leo-Pekka Lyytik{\"a}inen and Nicola Martinelli and Ute Mons and Nelson, {Christopher P} and Kjell Nikus and Pilbrow, {Anna P} and Rafal Ploski and Sun, {Yan V} and Tanck, {Michael W T} and Tang, {W H Wilson} and Stella Trompet and {van der Laan}, {Sander W} and {Van Setten}, Jessica and Vilmundarson, {Ragnar O} and {Viviani Anselmi}, Chiara and Efthymia Vlachopoulou and {Al Ali}, Lawien and Eric Boerwinkle and Carlo Briguori and Carlquist, {John F} and Carruthers, {Kathryn F} and Gavino Casu and John Deanfield and Panos Deloukas and Frank Dudbridge and Thomas Engstr{\"o}m and Natalie Fitzpatrick and Kim Fox and Bruna Gigante and Stefan James and Marja-Liisa Lokki and Lotufo, {Paulo A} and Nicola Marziliano and Mordi, {Ify R} and Muhlestein, {Joseph B} and Christopher Newton-Cheh and Jan Pitha and Saely, {Christoph H} and Ayman Samman-Tahhan and Sandesara, {Pratik B} and Andrej Teren and Adam Timmis and {Van de Werf}, Frans and Els Wauters and Wilde, {Arthur A M} and Ian Ford and Stott, {David J} and Ale Algra and Andreassi, {Maria G} and Diego Ardissino and Arsenault, {Benoit J} and Ballantyne, {Christie M} and Bergmeijer, {Thomas O} and Bezzina, {Connie R} and Body, {Simon C} and Boersma, {Eric H} and Peter Bogaty and Michiel Bots and Hermann Brenner and Brugts, {Jasper J} and Ralph Burkhardt and Clara Carpeggiani and Gianluigi Condorelli and Cooper-DeHoff, {Rhonda M} and Sharon Cresci and Nicolas Danchin and {de Faire}, Ulf and Doughty, {Robert N} and Heinz Drexel and Engert, {James C} and Fox, {Keith A A} and Domenico Girelli and Grobbee, {Diederick E} and Emil Hagstr{\"o}m and Hazen, {Stanley L} and Claes Held and Harry Hemingway and Hoefer, {Imo E} and Hovingh, {G Kees} and Reza Jabbari and Johnson, {Julie A} and Jukema, {J Wouter} and Kaczor, {Marcin P} and Mika K{\"a}h{\"o}nen and Jiri Kettner and Marek Kiliszek and Klungel, {Olaf H} and Bo Lagerqvist and Diether Lambrechts and Laurikka, {Jari O} and Terho Lehtim{\"a}ki and Daniel Lindholm and Mahmoodi, {B K} and {Maitland-van der Zee}, {Anke H} and Ruth McPherson and Olle Melander and Andres Metspalu and Anna Niemcunowicz-Janica and Oliviero Olivieri and Grzegorz Opolski and Palmer, {Colin N} and Gerard Pasterkamp and Pepine, {Carl J} and Pereira, {Alexandre C} and Louise Pilote and Quyyumi, {Arshed A} and Richards, {A Mark} and Marek Sanak and Agneta Siegbahn and Tabassome Simon and Juha Sinisalo and Smith, {J Gustav} and Spertus, {John A} and Steen Stender and Stewart, {Alexandre F R} and Wojciech Szczeklik and Anna Szpakowicz and Jean-Claude Tardif and {Ten Berg}, {Jurri{\"e}n M} and Jacob Tfelt-Hansen and George Thanassoulis and Joachim Thiery and Christian Torp-Pedersen and {van der Graaf}, Yolanda and Visseren, {Frank L J} and Johannes Waltenberger and Weeke, {Peter E} and {Van der Harst}, Pim and Lang, {Chim C} and Naveed Sattar and Cameron, {Vicky A} and Anderson, {Jeffrey L} and Brophy, {James M} and Guillaume Par{\'e} and Horne, {Benjamin D} and Winfried M{\"a}rz and Lars Wallentin and Samani, {Nilesh J} and Hingorani, {Aroon D} and Asselbergs, {Folkert W}",

year = "2019",

month = apr,

doi = "10.1161/CIRCGEN.119.002470",

language = "English",

volume = "12",

pages = "145--160",

journal = "CIRCULATION-GENOMIC AND PRECISION MEDICINE",

issn = "2574-8300",

publisher = "Lippincott Williams & Wilkins",

number = "4",

}

Patel, R, Tragante, V, Schmidt, AF, McCubrey, RO, Holmes, MV, Howe, LJ, Direk, K, Åkerblom, A, Leander, K, Virani, SS, Kaminski, KA, Muehlschlegel, JD, Allayee, H, Almgren, P, Alver, M, Baranova, EV, Behlouli, H, Boeckx, B, Braund, PS, Breitling, LP, Delgado, G, Duarte, NE, Dubé, M-P, Dufresne, L, Eriksson, N, Foco, L, Scholz, M, Gijsberts, CM, Glinge, C, Gong, Y, Hartiala, J, Heydarpour, M, Hubacek, JA, Kleber, M, Kofink, D, Kotti, S, Kuukasjärvi, P, Lee, V-V, Leiherer, A, Lenzini, PA, Levin, D, Lyytikäinen, L-P, Martinelli, N, Mons, U, Nelson, CP, Nikus, K, Pilbrow, AP, Ploski, R, Sun, YV, Tanck, MWT, Tang, WHW, Trompet, S, van der Laan, SW, Van Setten, J, Vilmundarson, RO, Viviani Anselmi, C, Vlachopoulou, E, Al Ali, L, Boerwinkle, E, Briguori, C, Carlquist, JF, Carruthers, KF, Casu, G, Deanfield, J, Deloukas, P, Dudbridge, F, Engström, T, Fitzpatrick, N, Fox, K, Gigante, B, James, S, Lokki, M-L, Lotufo, PA, Marziliano, N, Mordi, IR, Muhlestein, JB, Newton-Cheh, C, Pitha, J, Saely, CH, Samman-Tahhan, A, Sandesara, PB, Teren, A, Timmis, A, Van de Werf, F, Wauters, E, Wilde, AAM, Ford, I, Stott, DJ, Algra, A, Andreassi, MG, Ardissino, D, Arsenault, BJ, Ballantyne, CM, Bergmeijer, TO, Bezzina, CR, Body, SC, Boersma, EH, Bogaty, P, Bots, M, Brenner, H, Brugts, JJ, Burkhardt, R, Carpeggiani, C, Condorelli, G, Cooper-DeHoff, RM, Cresci, S, Danchin, N, de Faire, U, Doughty, RN, Drexel, H, Engert, JC, Fox, KAA, Girelli, D, Grobbee, DE, Hagström, E, Hazen, SL, Held, C, Hemingway, H, Hoefer, IE, Hovingh, GK, Jabbari, R, Johnson, JA, Jukema, JW, Kaczor, MP, Kähönen, M, Kettner, J, Kiliszek, M, Klungel, OH, Lagerqvist, B, Lambrechts, D, Laurikka, JO, Lehtimäki, T, Lindholm, D, Mahmoodi, BK, Maitland-van der Zee, AH, McPherson, R, Melander, O, Metspalu, A, Niemcunowicz-Janica, A, Olivieri, O, Opolski, G, Palmer, CN, Pasterkamp, G, Pepine, CJ, Pereira, AC, Pilote, L, Quyyumi, AA, Richards, AM, Sanak, M, Siegbahn, A, Simon, T, Sinisalo, J, Smith, JG, Spertus, JA, Stender, S, Stewart, AFR, Szczeklik, W, Szpakowicz, A, Tardif, J-C, Ten Berg, JM, Tfelt-Hansen, J, Thanassoulis, G, Thiery, J, Torp-Pedersen, C, van der Graaf, Y, Visseren, FLJ, Waltenberger, J, Weeke, PE, Van der Harst, P, Lang, CC, Sattar, N, Cameron, VA, Anderson, JL, Brophy, JM, Paré, G, Horne, BD, März, W, Wallentin, L, Samani, NJ, Hingorani, AD & Asselbergs, FW 2019, 'Subsequent Event Risk in Individuals with Established Coronary Heart Disease: Design and Rationale of the GENIUS-CHD Consortium', CIRCULATION-GENOMIC AND PRECISION MEDICINE, vol. 12, no. 4, pp. 145-160. https://doi.org/10.1161/CIRCGEN.119.002470

TY - JOUR

T1 - Subsequent Event Risk in Individuals with Established Coronary Heart Disease

T2 - Design and Rationale of the GENIUS-CHD Consortium

AU - Patel, Riyaz

AU - Tragante, Vinicius

AU - Schmidt, Amand F

AU - McCubrey, Raymond O

AU - Holmes, Michael V

AU - Howe, Laurence J

AU - Direk, Kenan

AU - Åkerblom, Axel

AU - Leander, Karin

AU - Virani, Salim S

AU - Kaminski, Karol A

AU - Muehlschlegel, Jochen D

AU - Allayee, Hooman

AU - Almgren, Peter

AU - Alver, Maris

AU - Baranova, Ekaterina V

AU - Behlouli, Hassan

AU - Boeckx, Bram

AU - Braund, Peter S

AU - Breitling, Lutz P

AU - Delgado, Graciela

AU - Duarte, Nubia E

AU - Dubé, Marie-Pierre

AU - Dufresne, Line

AU - Eriksson, Niclas

AU - Foco, Luisa

AU - Scholz, Markus

AU - Gijsberts, Crystel M

AU - Glinge, Charlotte

AU - Gong, Yan

AU - Hartiala, Jaana

AU - Heydarpour, Mahyar

AU - Hubacek, Jaroslav A

AU - Kleber, Marcus

AU - Kofink, Daniel

AU - Kotti, Salma

AU - Kuukasjärvi, Pekka

AU - Lee, Vei-Vei

AU - Leiherer, Andreas

AU - Lenzini, Petra A

AU - Levin, Daniel

AU - Lyytikäinen, Leo-Pekka

AU - Martinelli, Nicola

AU - Mons, Ute

AU - Nelson, Christopher P

AU - Nikus, Kjell

AU - Pilbrow, Anna P

AU - Ploski, Rafal

AU - Sun, Yan V

AU - Tanck, Michael W T

AU - Tang, W H Wilson

AU - Trompet, Stella

AU - van der Laan, Sander W

AU - Van Setten, Jessica

AU - Vilmundarson, Ragnar O

AU - Viviani Anselmi, Chiara

AU - Vlachopoulou, Efthymia

AU - Al Ali, Lawien

AU - Boerwinkle, Eric

AU - Briguori, Carlo

AU - Carlquist, John F

AU - Carruthers, Kathryn F

AU - Casu, Gavino

AU - Deanfield, John

AU - Deloukas, Panos

AU - Dudbridge, Frank

AU - Engström, Thomas

AU - Fitzpatrick, Natalie

AU - Fox, Kim

AU - Gigante, Bruna

AU - James, Stefan

AU - Lokki, Marja-Liisa

AU - Lotufo, Paulo A

AU - Marziliano, Nicola

AU - Mordi, Ify R

AU - Muhlestein, Joseph B

AU - Newton-Cheh, Christopher

AU - Pitha, Jan

AU - Saely, Christoph H

AU - Samman-Tahhan, Ayman

AU - Sandesara, Pratik B

AU - Teren, Andrej

AU - Timmis, Adam

AU - Van de Werf, Frans

AU - Wauters, Els

AU - Wilde, Arthur A M

AU - Ford, Ian

AU - Stott, David J

AU - Algra, Ale

AU - Andreassi, Maria G

AU - Ardissino, Diego

AU - Arsenault, Benoit J

AU - Ballantyne, Christie M

AU - Bergmeijer, Thomas O

AU - Bezzina, Connie R

AU - Body, Simon C

AU - Boersma, Eric H

AU - Bogaty, Peter

AU - Bots, Michiel

AU - Brenner, Hermann

AU - Brugts, Jasper J

AU - Burkhardt, Ralph

AU - Carpeggiani, Clara

AU - Condorelli, Gianluigi

AU - Cooper-DeHoff, Rhonda M

AU - Cresci, Sharon

AU - Danchin, Nicolas

AU - de Faire, Ulf

AU - Doughty, Robert N

AU - Drexel, Heinz

AU - Engert, James C

AU - Fox, Keith A A

AU - Girelli, Domenico

AU - Grobbee, Diederick E

AU - Hagström, Emil

AU - Hazen, Stanley L

AU - Held, Claes

AU - Hemingway, Harry

AU - Hoefer, Imo E

AU - Hovingh, G Kees

AU - Jabbari, Reza

AU - Johnson, Julie A

AU - Jukema, J Wouter

AU - Kaczor, Marcin P

AU - Kähönen, Mika

AU - Kettner, Jiri

AU - Kiliszek, Marek

AU - Klungel, Olaf H

AU - Lagerqvist, Bo

AU - Lambrechts, Diether

AU - Laurikka, Jari O

AU - Lehtimäki, Terho

AU - Lindholm, Daniel

AU - Mahmoodi, B K

AU - Maitland-van der Zee, Anke H

AU - McPherson, Ruth

AU - Melander, Olle

AU - Metspalu, Andres

AU - Niemcunowicz-Janica, Anna

AU - Olivieri, Oliviero

AU - Opolski, Grzegorz

AU - Palmer, Colin N

AU - Pasterkamp, Gerard

AU - Pepine, Carl J

AU - Pereira, Alexandre C

AU - Pilote, Louise

AU - Quyyumi, Arshed A

AU - Richards, A Mark

AU - Sanak, Marek

AU - Siegbahn, Agneta

AU - Simon, Tabassome

AU - Sinisalo, Juha

AU - Smith, J Gustav

AU - Spertus, John A

AU - Stender, Steen

AU - Stewart, Alexandre F R

AU - Szczeklik, Wojciech

AU - Szpakowicz, Anna

AU - Tardif, Jean-Claude

AU - Ten Berg, Jurriën M

AU - Tfelt-Hansen, Jacob

AU - Thanassoulis, George

AU - Thiery, Joachim

AU - Torp-Pedersen, Christian

AU - van der Graaf, Yolanda

AU - Visseren, Frank L J

AU - Waltenberger, Johannes

AU - Weeke, Peter E

AU - Van der Harst, Pim

AU - Lang, Chim C

AU - Sattar, Naveed

AU - Cameron, Vicky A

AU - Anderson, Jeffrey L

AU - Brophy, James M

AU - Paré, Guillaume

AU - Horne, Benjamin D

AU - März, Winfried

AU - Wallentin, Lars

AU - Samani, Nilesh J

AU - Hingorani, Aroon D

AU - Asselbergs, Folkert W

PY - 2019/4

Y1 - 2019/4

N2 - BACKGROUND: The Genetics of Subsequent Coronary Heart Disease (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events, in individuals with established CHD.METHODS: The consortium currently includes 57 studies from 18 countries, recruiting 185 614 participants with either acute coronary syndrome, stable CHD, or a mixture of both at baseline. All studies collected biological samples and followed-up study participants prospectively for subsequent events.RESULTS: Enrollment into the individual studies took place between 1985 to present day with a duration of follow-up ranging from 9 months to 15 years. Within each study, participants with CHD are predominantly of self-reported European descent (38%-100%), mostly male (44%-91%) with mean ages at recruitment ranging from 40 to 75 years. Initial feasibility analyses, using a federated analysis approach, yielded expected associations between age (hazard ratio, 1.15; 95% CI, 1.14-1.16) per 5-year increase, male sex (hazard ratio, 1.17; 95% CI, 1.13-1.21) and smoking (hazard ratio, 1.43; 95% CI, 1.35-1.51) with risk of subsequent CHD death or myocardial infarction and differing associations with other individual and composite cardiovascular endpoints.CONCLUSIONS: GENIUS-CHD is a global collaboration seeking to elucidate genetic and nongenetic determinants of subsequent event risk in individuals with established CHD, to improve residual risk prediction and identify novel drug targets for secondary prevention. Initial analyses demonstrate the feasibility and reliability of a federated analysis approach. The consortium now plans to initiate and test novel hypotheses as well as supporting replication and validation analyses for other investigators.

AB - BACKGROUND: The Genetics of Subsequent Coronary Heart Disease (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events, in individuals with established CHD.METHODS: The consortium currently includes 57 studies from 18 countries, recruiting 185 614 participants with either acute coronary syndrome, stable CHD, or a mixture of both at baseline. All studies collected biological samples and followed-up study participants prospectively for subsequent events.RESULTS: Enrollment into the individual studies took place between 1985 to present day with a duration of follow-up ranging from 9 months to 15 years. Within each study, participants with CHD are predominantly of self-reported European descent (38%-100%), mostly male (44%-91%) with mean ages at recruitment ranging from 40 to 75 years. Initial feasibility analyses, using a federated analysis approach, yielded expected associations between age (hazard ratio, 1.15; 95% CI, 1.14-1.16) per 5-year increase, male sex (hazard ratio, 1.17; 95% CI, 1.13-1.21) and smoking (hazard ratio, 1.43; 95% CI, 1.35-1.51) with risk of subsequent CHD death or myocardial infarction and differing associations with other individual and composite cardiovascular endpoints.CONCLUSIONS: GENIUS-CHD is a global collaboration seeking to elucidate genetic and nongenetic determinants of subsequent event risk in individuals with established CHD, to improve residual risk prediction and identify novel drug targets for secondary prevention. Initial analyses demonstrate the feasibility and reliability of a federated analysis approach. The consortium now plans to initiate and test novel hypotheses as well as supporting replication and validation analyses for other investigators.

KW - coronary artery disease

KW - genetics

KW - myocardial infarction

KW - prognosis

KW - secondary prevention

UR - http://www.scopus.com/inward/record.url?scp=85069626441&partnerID=8YFLogxK

U2 - 10.1161/CIRCGEN.119.002470

DO - 10.1161/CIRCGEN.119.002470

M3 - Journal article

C2 - 30896328

SN - 2574-8300

VL - 12

SP - 145

EP - 160

JO - CIRCULATION-GENOMIC AND PRECISION MEDICINE

JF - CIRCULATION-GENOMIC AND PRECISION MEDICINE

IS - 4

ER -

Subsequent Event Risk in Individuals with Established Coronary Heart Disease: Design and Rationale of the GENIUS-CHD Consortium

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