Survival after a nationwide adoption of robotic minimally invasive surgery for early-stage cervical cancer - A population-based study

Pernille T Jensen, Tine H Schnack, Ligita P Frøding, Signe F Bjørn, Henrik Lajer, Algirdas Markauskas, Kirsten M Jochumsen, Katrine Fuglsang, Jacob Dinesen, Charlotte H Søgaard, Erik Søgaard-Andersen, Marianne M Jensen, Aage Knudsen, Laura H Øster, Claus Høgdall

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23 Citations (Scopus)

Abstract

AIM: Lately, the safety of minimally invasive surgery (MIS) in the treatment of cervical cancer (CC) has been questioned. This study aimed to evaluate the risk of recurrence and survival after a nationwide adoption of robotic MIS for the treatment of early-stage CC in Denmark.

METHODS: Population-based data on all Danish women with early-stage CC, who underwent radical hysterectomy January 1st 2005-June 30th 2017 were retrieved from the Danish Gynecologic Cancer Database and enriched with follow-up data on recurrence, death and cause of death. The cohort was divided into two groups according to the year of robotic MIS introduction at each cancer centre. Chi-squared or Fischer test, the Kaplan Meier method and multivariate Cox regression were used for comparison between groups.

RESULTS: One thousand one hundred twenty-five patients with CC were included; 530 underwent surgery before (group 1) and 595 underwent surgery after (group 2) the introduction of robotic MIS. The 5-year rate of recurrence was low: 8.2% and 6.3% (p = 0.55) in group 1 and 2, respectively. In adjusted analyses, this corresponded to a five-year disease-free survival, hazard ratio (HR) 1.23 [95% confidence interval (CI) 0.79-1.93]. No difference in site of recurrence (P = 0.19) was observed. The cumulative cancer-specific survival was 94.1% and 95.9% (P = 0.10) in group 1 and 2, respectively, corresponding to a HR 0.60 [95% CI 0.32-1.11] in adjusted analyses.

CONCLUSION: In this population-based cohort study, the Danish nationwide adoption of robotic MIS for early-stage CC was not associated with increased risk of recurrence or reduction in survival outcomes.

Original languageEnglish
JournalEuropean Journal of Cancer
Volume128
Pages (from-to)47-56
Number of pages10
ISSN0959-8049
DOIs
Publication statusPublished - Mar 2020

Keywords

  • Cancer recurrence
  • Cancer-specific survival
  • Cervical cancer
  • Disease-free survival
  • Minimally invasive surgery
  • Overall survival
  • Population-based study
  • Radical hysterectomy
  • Robotic surgery

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