Survival and long-term biochemical cure in medullary thyroid carcinoma in Denmark 1997-2014: A nationwide study

Jes Sloth Mathiesen, Jens Peter Kroustrup, Peter Vestergaard, Per Løgstrup Poulsen, Kirstine Stochholm, Åse Krogh Rasmussen, Ulla Feldt-Rasmussen, Sten Schytte, Stefano Christian Londero, Henrik Baymler Pedersen, Christoffer Holst Hahn, Jens Bentzen, Sören Möller, Mette Gaustadnes, Maria Rossing, Finn Cliius Nielsen, Kim Brixen, Anja Lisbeth Frederiksen, Christian Godballe

Research output: Contribution to journalJournal articleResearchpeer-review

10 Citations (Scopus)
89 Downloads (Pure)

Abstract

Background: Survival of medullary thyroid carcinoma (MTC) subgroups in relation to the general population is poorly described. Data on the factors predicting long-term biochemical cure in MTC patients are nonexistent at a population level. A nationwide retrospective cohort study of MTC in Denmark from 1997 to 2014 was conducted, aiming to detect subgroups with survival similar to that of the general population and to identify prognostic factors for disease-specific survival and long-term biochemical cure. Methods: The study included 220 patients identified from the nationwide Danish MTC cohort between 1997 and 2014. As a representative sample of the general population, a reference population matched 50:1 to the MTC cohort was used. Results: Patients diagnosed with hereditary MTC by screening (hazard ratio [HR] = 1.5 [confidence interval (CI) 0.5-4.3]), patients without regional metastases (HR = 1.4 [CI 0.9-2.3]), and patients with stage I (HR = 1.3 [CI 0.6-3.1]), stage II (HR = 1.1 [CI 0.6-2.3]), and III (HR = 1.3 [CI 0.4-4.2]) disease had an overall survival similar to the reference population. On multivariate analysis, the presence of distant metastases (HR = 12.3 [CI 6.0-25.0]) predicted worse disease-specific survival, while the absence of regional lymph node metastases (odds ratio = 40.1 [CI 12.0-133.7]) was the only independent prognostic factor for long-term biochemical cure. Conclusions: Patients with hereditary MTC diagnosed by screening, patients without regional metastases, and patients with stages I, II, and III disease may have similar survival as the general population. The presence of distant metastases predicted worse disease-specific survival, while the absence of regional metastases predicted long-term biochemical cure.

Original languageEnglish
JournalThyroid
Volume29
Issue number3
Pages (from-to)368-377
Number of pages10
ISSN1050-7256
DOIs
Publication statusPublished - Mar 2019

Keywords

  • Denmark
  • biochemical cure
  • medullary thyroid carcinoma
  • nationwide
  • population-based
  • survival

Fingerprint Dive into the research topics of 'Survival and long-term biochemical cure in medullary thyroid carcinoma in Denmark 1997-2014: A nationwide study'. Together they form a unique fingerprint.

  • Cite this

    Mathiesen, J. S., Kroustrup, J. P., Vestergaard, P., Poulsen, P. L., Stochholm, K., Rasmussen, Å. K., Feldt-Rasmussen, U., Schytte, S., Londero, S. C., Pedersen, H. B., Hahn, C. H., Bentzen, J., Möller, S., Gaustadnes, M., Rossing, M., Nielsen, F. C., Brixen, K., Frederiksen, A. L., & Godballe, C. (2019). Survival and long-term biochemical cure in medullary thyroid carcinoma in Denmark 1997-2014: A nationwide study. Thyroid, 29(3), 368-377. https://doi.org/10.1089/thy.2018.0564