Svær manisk enkeltepisode som følge af skift i antiepileptisk behandling

Nikolaj Liboriussen Drivsholm; Akbar Akbarzade Khoshgari; Michael Nielsen; Susanne Vendelbo Hovgesen; Marton Asztalos

doi:10.61409/V07250601

Svær manisk enkeltepisode som følge af skift i antiepileptisk behandling

Translated title of the contribution: Severe single manic episode due to a change in antiepileptic treatment

Nikolaj Liboriussen Drivsholm, Akbar Akbarzade Khoshgari, Michael Nielsen, Susanne Vendelbo Hovgesen, Marton Asztalos

Research output: Contribution to journal › Case Report › Research › peer-review

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Abstract

A 68-year-old man with well-controlled epilepsy and no history of mental health issues suddenly developed severe manic symptoms. These symptoms occurred after a change in his anticonvulsant treatment from carbamazepine to levetiracetam. After discontinuing Levetiracetam and initiating valproate and olanzapine treatment, the symptoms remitted, and the patient was discharged without psychiatric symptoms. This case demonstrates an example of the sudden onset of psychiatric symptoms with an organic cause.

Translated title of the contribution	Severe single manic episode due to a change in antiepileptic treatment
Original language	Danish
Article number	V07250601
Journal	Ugeskrift for laeger
Volume	187
Number of pages	3
ISSN	0041-5782
DOIs	https://doi.org/10.61409/V07250601
Publication status	Published - 15 Dec 2025

Bibliographical note

Published under Open Access CC-BY-NC-BD 4.0. https://creativecommons.org/licenses/by-nc-nd/4.0/.

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10.61409/V07250601Licence: CC BY-NC-ND 4.0

Drivsholm et al. (2025) Svær manisk enkeltepisode som følge af skift i antiepileptisk behandlingFinal published version, 48.1 KBLicence: CC BY-NC-ND 4.0

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title = "Sv{\ae}r manisk enkeltepisode som f{\o}lge af skift i antiepileptisk behandling",

abstract = "A 68-year-old man with well-controlled epilepsy and no history of mental health issues suddenly developed severe manic symptoms. These symptoms occurred after a change in his anticonvulsant treatment from carbamazepine to levetiracetam. After discontinuing Levetiracetam and initiating valproate and olanzapine treatment, the symptoms remitted, and the patient was discharged without psychiatric symptoms. This case demonstrates an example of the sudden onset of psychiatric symptoms with an organic cause.",

keywords = "Humans, Male, Anticonvulsants/adverse effects, Aged, Levetiracetam/adverse effects, Carbamazepine/adverse effects, Valproic Acid/adverse effects, Mania/chemically induced, Olanzapine, Epilepsy/drug therapy, Bipolar Disorder/chemically induced, Drug Substitution/adverse effects",

author = "Drivsholm, \{Nikolaj Liboriussen\} and Khoshgari, \{Akbar Akbarzade\} and Michael Nielsen and Hovgesen, \{Susanne Vendelbo\} and Marton Asztalos",

note = "Published under Open Access CC-BY-NC-BD 4.0. https://creativecommons.org/licenses/by-nc-nd/4.0/.",

year = "2025",

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doi = "10.61409/V07250601",

language = "Dansk",

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T1 - Svær manisk enkeltepisode som følge af skift i antiepileptisk behandling

AU - Drivsholm, Nikolaj Liboriussen

AU - Khoshgari, Akbar Akbarzade

AU - Nielsen, Michael

AU - Hovgesen, Susanne Vendelbo

AU - Asztalos, Marton

N1 - Published under Open Access CC-BY-NC-BD 4.0. https://creativecommons.org/licenses/by-nc-nd/4.0/.

PY - 2025/12/15

Y1 - 2025/12/15

N2 - A 68-year-old man with well-controlled epilepsy and no history of mental health issues suddenly developed severe manic symptoms. These symptoms occurred after a change in his anticonvulsant treatment from carbamazepine to levetiracetam. After discontinuing Levetiracetam and initiating valproate and olanzapine treatment, the symptoms remitted, and the patient was discharged without psychiatric symptoms. This case demonstrates an example of the sudden onset of psychiatric symptoms with an organic cause.

AB - A 68-year-old man with well-controlled epilepsy and no history of mental health issues suddenly developed severe manic symptoms. These symptoms occurred after a change in his anticonvulsant treatment from carbamazepine to levetiracetam. After discontinuing Levetiracetam and initiating valproate and olanzapine treatment, the symptoms remitted, and the patient was discharged without psychiatric symptoms. This case demonstrates an example of the sudden onset of psychiatric symptoms with an organic cause.

KW - Humans

KW - Male

KW - Anticonvulsants/adverse effects

KW - Aged

KW - Levetiracetam/adverse effects

KW - Carbamazepine/adverse effects

KW - Valproic Acid/adverse effects

KW - Mania/chemically induced

KW - Olanzapine

KW - Epilepsy/drug therapy

KW - Bipolar Disorder/chemically induced

KW - Drug Substitution/adverse effects

U2 - 10.61409/V07250601

DO - 10.61409/V07250601

M3 - Kasuistik

C2 - 41489143

SN - 0041-5782

VL - 187

JO - Ugeskrift for laeger

JF - Ugeskrift for laeger

M1 - V07250601

ER -

Svær manisk enkeltepisode som følge af skift i antiepileptisk behandling

Abstract

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