Abstract
Objectives: Mast cell involvement is evident in functional gastrointestinal disorders (FGID). FGID and mast cell activation syndrome (MCAS) are associated with multi-organ symptoms. An overlap has not been assessed.Methods: MCAS symptoms were determined by questionnaires in 2083 FGID patients.Results: The median number of MCAS symptoms ([IQR] (range 0-16)) was 6 [4-8] in all FGID, and in functional dyspepsia (FD) patients, 7 [5-9] in overlapping irritable bowel syndrome and FD (IBS+FD), 5 [3-8] in IBS and 5 [3-6] in non-IBS/non-FD (p < .001 vs. FD and IBS + FD) patients. MCAS symptoms in ≥2 organ-systems existed in 1773 (85%) of all patients.Conclusions: MCAS symptoms are common in FGID warranting further mechanistic investigation.
Original language | English |
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Journal | Scandinavian Journal of Gastroenterology |
Volume | 54 |
Issue number | 11 |
Pages (from-to) | 1322-1325 |
Number of pages | 4 |
ISSN | 0036-5521 |
DOIs | |
Publication status | Published - Nov 2019 |
Keywords
- Histamine
- functional dyspepsia
- irritable bowel syndrome
- mast cell