Systematic Screening for Late Sequelae after Colorectal Cancer - a Feasibility Study

Therese Juul; Annette Boesen Bräuner; Asbjørn Mohr Drewes; Katrine Jøssing Emmertsen; Klaus Krogh; Søren Laurberg; Michael Bødker Lauritzen; Ole Thorlacius-Ussing; Peter Christensen; Danish Cancer Society Centre for Research on Survivorship and Late Adverse Effects after Cancer in the Pelvic Organs Study Group

doi:10.1111/codi.15519

Systematic Screening for Late Sequelae after Colorectal Cancer - a Feasibility Study

Therese Juul^*, Annette Boesen Bräuner, Asbjørn Mohr Drewes, Katrine Jøssing Emmertsen, Klaus Krogh, Søren Laurberg, Michael Bødker Lauritzen, Ole Thorlacius-Ussing, Peter Christensen, Danish Cancer Society Centre for Research on Survivorship and Late Adverse Effects after Cancer in the Pelvic Organs Study Group

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

AIM: The aim of this study was to test the feasibility of a new method for systematic screening for late sequelae (LS) following colorectal cancer treatment.

METHOD: Patients with colorectal cancer from five Danish hospitals were invited to complete a survey about LS at 3, 12, 24 and 36 months after surgery as part of their follow-up. The survey consisted primarily of validated tools, supplemented by a few ad hoc items, measuring bowel, urinary and sexual dysfunction, pain and quality of life and an additional question regarding request for contact. Patients completed surveys electronically or on paper.

RESULTS: Of the 1721 invited patients, 1386 (80.5%) were included (1085 with colon cancer and 301 with rectal cancer) of whom 72.5% responded electronically. Patients responding electronically were 7.6 years younger than those responding on paper (P < 0.001). Since some patients answered more than once, the dataset consisted of 2361 surveys. Patients with colon cancer requested phone contact in 19.0% of the surveys, and 8.4% were referred to treatment for LS, primarily bowel dysfunction. Among patients with rectal cancer, 30.8% requested phone contact and 16.2% were referred for treatment of LS, mainly due to bowel and sexual dysfunction.

CONCLUSION: This is the first paper investigating a new method of systematic screening for LS following colorectal cancer using electronic patient-reported outcome measures. The study shows that in the Danish population a high response rate can be obtained with this method and that close to three-quarters of patients respond electronically. Patients with rectal cancer had a higher need for phone contact and treatment of LS than patients with colon cancer.

Original language	English
Journal	Colorectal Disease
Volume	23
Issue number	2
Pages (from-to)	345-355
Number of pages	11
ISSN	1462-8910
DOIs	https://doi.org/10.1111/codi.15519
Publication status	Published - Feb 2021

Bibliographical note

he study was funded by the Danish Cancer Society, grant R192-A11536. Therese Juul was partly supported by the Novo Nordisk Foundation grant NNF19OC0022988. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.

Keywords

Colorectal cancer
LARS
bowel function
cancer survivorship
follow up
late sequelae
quality of life
sexual function
urinary function

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10.1111/codi.15519

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Juul, T., Bräuner, A. B., Drewes, A. M., Emmertsen, K. J., Krogh, K., Laurberg, S., Lauritzen, M. B., Thorlacius-Ussing, O., Christensen, P., & Danish Cancer Society Centre for Research on Survivorship and Late Adverse Effects after Cancer in the Pelvic Organs Study Group (2021). Systematic Screening for Late Sequelae after Colorectal Cancer - a Feasibility Study. Colorectal Disease, 23(2), 345-355. Advance online publication. https://doi.org/10.1111/codi.15519

@article{337db37e527f4439bdf685ac688cd2f6,

title = "Systematic Screening for Late Sequelae after Colorectal Cancer - a Feasibility Study",

abstract = "AIM: The aim of this study was to test the feasibility of a new method for systematic screening for late sequelae (LS) following colorectal cancer treatment.METHOD: Patients with colorectal cancer from five Danish hospitals were invited to complete a survey about LS at 3, 12, 24 and 36 months after surgery as part of their follow-up. The survey consisted primarily of validated tools, supplemented by a few ad hoc items, measuring bowel, urinary and sexual dysfunction, pain and quality of life and an additional question regarding request for contact. Patients completed surveys electronically or on paper.RESULTS: Of the 1721 invited patients, 1386 (80.5%) were included (1085 with colon cancer and 301 with rectal cancer) of whom 72.5% responded electronically. Patients responding electronically were 7.6 years younger than those responding on paper (P < 0.001). Since some patients answered more than once, the dataset consisted of 2361 surveys. Patients with colon cancer requested phone contact in 19.0% of the surveys, and 8.4% were referred to treatment for LS, primarily bowel dysfunction. Among patients with rectal cancer, 30.8% requested phone contact and 16.2% were referred for treatment of LS, mainly due to bowel and sexual dysfunction.CONCLUSION: This is the first paper investigating a new method of systematic screening for LS following colorectal cancer using electronic patient-reported outcome measures. The study shows that in the Danish population a high response rate can be obtained with this method and that close to three-quarters of patients respond electronically. Patients with rectal cancer had a higher need for phone contact and treatment of LS than patients with colon cancer.",

keywords = "Colorectal cancer, LARS, bowel function, cancer survivorship, follow up, late sequelae, quality of life, sexual function, urinary function",

author = "Therese Juul and Br{\"a}uner, {Annette Boesen} and Drewes, {Asbj{\o}rn Mohr} and Emmertsen, {Katrine J{\o}ssing} and Klaus Krogh and S{\o}ren Laurberg and Lauritzen, {Michael B{\o}dker} and Ole Thorlacius-Ussing and Peter Christensen and {Danish Cancer Society Centre for Research on Survivorship and Late Adverse Effects after Cancer in the Pelvic Organs Study Group}",

note = "he study was funded by the Danish Cancer Society, grant R192-A11536. Therese Juul was partly supported by the Novo Nordisk Foundation grant NNF19OC0022988. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.",

year = "2021",

month = feb,

doi = "10.1111/codi.15519",

language = "English",

volume = "23",

pages = "345--355",

journal = "Colorectal Disease",

issn = "1462-8910",

publisher = "Wiley-Blackwell",

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Juul, T, Bräuner, AB, Drewes, AM, Emmertsen, KJ, Krogh, K, Laurberg, S, Lauritzen, MB , Thorlacius-Ussing, O, Christensen, P & Danish Cancer Society Centre for Research on Survivorship and Late Adverse Effects after Cancer in the Pelvic Organs Study Group 2021, 'Systematic Screening for Late Sequelae after Colorectal Cancer - a Feasibility Study', Colorectal Disease, vol. 23, no. 2, pp. 345-355. https://doi.org/10.1111/codi.15519

TY - JOUR

T1 - Systematic Screening for Late Sequelae after Colorectal Cancer - a Feasibility Study

AU - Juul, Therese

AU - Bräuner, Annette Boesen

AU - Drewes, Asbjørn Mohr

AU - Emmertsen, Katrine Jøssing

AU - Krogh, Klaus

AU - Laurberg, Søren

AU - Lauritzen, Michael Bødker

AU - Thorlacius-Ussing, Ole

AU - Christensen, Peter

AU - Danish Cancer Society Centre for Research on Survivorship and Late Adverse Effects after Cancer in the Pelvic Organs Study Group

N1 - he study was funded by the Danish Cancer Society, grant R192-A11536. Therese Juul was partly supported by the Novo Nordisk Foundation grant NNF19OC0022988. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.

PY - 2021/2

Y1 - 2021/2

N2 - AIM: The aim of this study was to test the feasibility of a new method for systematic screening for late sequelae (LS) following colorectal cancer treatment.METHOD: Patients with colorectal cancer from five Danish hospitals were invited to complete a survey about LS at 3, 12, 24 and 36 months after surgery as part of their follow-up. The survey consisted primarily of validated tools, supplemented by a few ad hoc items, measuring bowel, urinary and sexual dysfunction, pain and quality of life and an additional question regarding request for contact. Patients completed surveys electronically or on paper.RESULTS: Of the 1721 invited patients, 1386 (80.5%) were included (1085 with colon cancer and 301 with rectal cancer) of whom 72.5% responded electronically. Patients responding electronically were 7.6 years younger than those responding on paper (P < 0.001). Since some patients answered more than once, the dataset consisted of 2361 surveys. Patients with colon cancer requested phone contact in 19.0% of the surveys, and 8.4% were referred to treatment for LS, primarily bowel dysfunction. Among patients with rectal cancer, 30.8% requested phone contact and 16.2% were referred for treatment of LS, mainly due to bowel and sexual dysfunction.CONCLUSION: This is the first paper investigating a new method of systematic screening for LS following colorectal cancer using electronic patient-reported outcome measures. The study shows that in the Danish population a high response rate can be obtained with this method and that close to three-quarters of patients respond electronically. Patients with rectal cancer had a higher need for phone contact and treatment of LS than patients with colon cancer.

AB - AIM: The aim of this study was to test the feasibility of a new method for systematic screening for late sequelae (LS) following colorectal cancer treatment.METHOD: Patients with colorectal cancer from five Danish hospitals were invited to complete a survey about LS at 3, 12, 24 and 36 months after surgery as part of their follow-up. The survey consisted primarily of validated tools, supplemented by a few ad hoc items, measuring bowel, urinary and sexual dysfunction, pain and quality of life and an additional question regarding request for contact. Patients completed surveys electronically or on paper.RESULTS: Of the 1721 invited patients, 1386 (80.5%) were included (1085 with colon cancer and 301 with rectal cancer) of whom 72.5% responded electronically. Patients responding electronically were 7.6 years younger than those responding on paper (P < 0.001). Since some patients answered more than once, the dataset consisted of 2361 surveys. Patients with colon cancer requested phone contact in 19.0% of the surveys, and 8.4% were referred to treatment for LS, primarily bowel dysfunction. Among patients with rectal cancer, 30.8% requested phone contact and 16.2% were referred for treatment of LS, mainly due to bowel and sexual dysfunction.CONCLUSION: This is the first paper investigating a new method of systematic screening for LS following colorectal cancer using electronic patient-reported outcome measures. The study shows that in the Danish population a high response rate can be obtained with this method and that close to three-quarters of patients respond electronically. Patients with rectal cancer had a higher need for phone contact and treatment of LS than patients with colon cancer.

KW - Colorectal cancer

KW - LARS

KW - bowel function

KW - cancer survivorship

KW - follow up

KW - late sequelae

KW - quality of life

KW - sexual function

KW - urinary function

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U2 - 10.1111/codi.15519

DO - 10.1111/codi.15519

M3 - Journal article

C2 - 33420746

SN - 1462-8910

VL - 23

SP - 345

EP - 355

JO - Colorectal Disease

JF - Colorectal Disease

IS - 2

ER -

Systematic Screening for Late Sequelae after Colorectal Cancer - a Feasibility Study

Abstract

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