Temporal changes in survival among adult patients with acute myeloid leukaemia in the period 2000-2016: a Danish population-based study

Lasse Hjort  Jakobsen; Anne Stidsholt Roug; Andreas Kiesbye  Øvlisen; Claus Werenberg  Marcher; Hans Beier  Ommen; Kim Theilgaard-Mönch; Peter Møller; Claudia Schöllkopf; Daniel Kristensen; Therese Maria Henriette  Naur; Martin Bøgsted; Tarec Christoffer  El-Galaly; Marianne Tang  Severinsen

doi:10.1111/bjh.17213

Temporal changes in survival among adult patients with acute myeloid leukaemia in the period 2000-2016: a Danish population-based study

Lasse Hjort Jakobsen^*, Anne Stidsholt Roug, Andreas Kiesbye Øvlisen, Claus Werenberg Marcher, Hans Beier Ommen, Kim Theilgaard-Mönch, Peter Møller, Claudia Schöllkopf, Daniel Kristensen, Therese Maria Henriette Naur, Martin Bøgsted, Tarec Christoffer El-Galaly, Marianne Tang Severinsen

^*Corresponding author for this work

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Abstract

In the present study, we quantify the progress in overall survival (OS) during the period 2000-2016 among Danish patients with acute myeloid leukaemia (AML). This population-based study, including 3820 adult patients with AML, demonstrates a significantly improved OS over time with the 2-year age-standardised OS increasing from 22% in 2002 to 31% in 2016. The improvement in OS was exclusively seen in patients with AML aged ≥50 years, with absolute improvements in 2-year OS from 2002 to 2016 of ≥10% among patients aged 50-75 years and a small absolute increase in those aged >75 years.

Original language	English
Journal	British Journal of Haematology
Volume	193
Issue number	3
Pages (from-to)	482-487
Number of pages	6
ISSN	0007-1048
DOIs	https://doi.org/10.1111/bjh.17213
Publication status	Published - May 2021

Keywords

acute myeloid leukaemia
real-world patients
temporal survival

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10.1111/bjh.17213

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Jakobsen, L. H., Roug, A. S., Øvlisen, A. K., Marcher, C. W., Ommen, H. B., Theilgaard-Mönch, K., Møller, P., Schöllkopf, C., Kristensen, D., Naur, T. M. H., Bøgsted, M., El-Galaly, T. C., & Severinsen, M. T. (2021). Temporal changes in survival among adult patients with acute myeloid leukaemia in the period 2000-2016: a Danish population-based study. British Journal of Haematology, 193(3), 482-487. Advance online publication. https://doi.org/10.1111/bjh.17213

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title = "Temporal changes in survival among adult patients with acute myeloid leukaemia in the period 2000-2016: a Danish population-based study",

abstract = "In the present study, we quantify the progress in overall survival (OS) during the period 2000-2016 among Danish patients with acute myeloid leukaemia (AML). This population-based study, including 3820 adult patients with AML, demonstrates a significantly improved OS over time with the 2-year age-standardised OS increasing from 22% in 2002 to 31% in 2016. The improvement in OS was exclusively seen in patients with AML aged ≥50 years, with absolute improvements in 2-year OS from 2002 to 2016 of ≥10% among patients aged 50-75 years and a small absolute increase in those aged >75 years.",

keywords = "acute myeloid leukaemia, real-world patients, temporal survival",

author = "Jakobsen, {Lasse Hjort} and Roug, {Anne Stidsholt} and {\O}vlisen, {Andreas Kiesbye} and Marcher, {Claus Werenberg} and Ommen, {Hans Beier} and Kim Theilgaard-M{\"o}nch and Peter M{\o}ller and Claudia Sch{\"o}llkopf and Daniel Kristensen and Naur, {Therese Maria Henriette} and Martin B{\o}gsted and El-Galaly, {Tarec Christoffer} and Severinsen, {Marianne Tang}",

note = "{\textcopyright} 2020 British Society for Haematology and John Wiley & Sons Ltd.",

year = "2021",

month = may,

doi = "10.1111/bjh.17213",

language = "English",

volume = "193",

pages = "482--487",

journal = "British Journal of Haematology",

issn = "0007-1048",

publisher = "Wiley-Blackwell",

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Jakobsen, LH , Roug, AS , Øvlisen, AK, Marcher, CW, Ommen, HB, Theilgaard-Mönch, K, Møller, P, Schöllkopf, C, Kristensen, D, Naur, TMH, Bøgsted, M , El-Galaly, TC & Severinsen, MT 2021, 'Temporal changes in survival among adult patients with acute myeloid leukaemia in the period 2000-2016: a Danish population-based study', British Journal of Haematology, vol. 193, no. 3, pp. 482-487. https://doi.org/10.1111/bjh.17213

Temporal changes in survival among adult patients with acute myeloid leukaemia in the period 2000-2016: a Danish population-based study. / Jakobsen, Lasse Hjort ; Roug, Anne Stidsholt ; Øvlisen, Andreas Kiesbye et al.
In: British Journal of Haematology, Vol. 193, No. 3, 05.2021, p. 482-487.

Research output: Contribution to journal › Journal article › Research › peer-review

TY - JOUR

T1 - Temporal changes in survival among adult patients with acute myeloid leukaemia in the period 2000-2016

T2 - a Danish population-based study

AU - Jakobsen, Lasse Hjort

AU - Roug, Anne Stidsholt

AU - Øvlisen, Andreas Kiesbye

AU - Marcher, Claus Werenberg

AU - Ommen, Hans Beier

AU - Theilgaard-Mönch, Kim

AU - Møller, Peter

AU - Schöllkopf, Claudia

AU - Kristensen, Daniel

AU - Naur, Therese Maria Henriette

AU - Bøgsted, Martin

AU - El-Galaly, Tarec Christoffer

AU - Severinsen, Marianne Tang

PY - 2021/5

Y1 - 2021/5

N2 - In the present study, we quantify the progress in overall survival (OS) during the period 2000-2016 among Danish patients with acute myeloid leukaemia (AML). This population-based study, including 3820 adult patients with AML, demonstrates a significantly improved OS over time with the 2-year age-standardised OS increasing from 22% in 2002 to 31% in 2016. The improvement in OS was exclusively seen in patients with AML aged ≥50 years, with absolute improvements in 2-year OS from 2002 to 2016 of ≥10% among patients aged 50-75 years and a small absolute increase in those aged >75 years.

AB - In the present study, we quantify the progress in overall survival (OS) during the period 2000-2016 among Danish patients with acute myeloid leukaemia (AML). This population-based study, including 3820 adult patients with AML, demonstrates a significantly improved OS over time with the 2-year age-standardised OS increasing from 22% in 2002 to 31% in 2016. The improvement in OS was exclusively seen in patients with AML aged ≥50 years, with absolute improvements in 2-year OS from 2002 to 2016 of ≥10% among patients aged 50-75 years and a small absolute increase in those aged >75 years.

KW - acute myeloid leukaemia

KW - real-world patients

KW - temporal survival

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C2 - 33222154

SN - 0007-1048

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SP - 482

EP - 487

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 3

ER -

Temporal changes in survival among adult patients with acute myeloid leukaemia in the period 2000-2016: a Danish population-based study

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