Testicular microlithiasis in patients with testicular cancer in the United Kingdom and in Denmark

Malene Roland Pedersen; Catherine Horsfield; Oliver Foot; Jan Lindebjerg; Palle Jørn Sloth Osther; Peter Vedsted; Ashish Chandra; Søren Rafael Rafaelsen; Henrik Møller

Testicular microlithiasis in patients with testicular cancer in the United Kingdom and in Denmark

Malene Roland Pedersen, Catherine Horsfield, Oliver Foot, Jan Lindebjerg, Palle Jørn Sloth Osther, Peter Vedsted, Ashish Chandra, Søren Rafael Rafaelsen, Henrik Møller

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

Abstract

INTRODUCTION: Testicular cancer is the most common type of cancer in young Caucasian men. It has been suggested that testicular microlithiasis (TML) is a premalignant condition. This study's objective was to investigate TML histology prevalence in testicular cancer patients in two European populations.

METHODS: We analysed archived histopathology orchiectomy specimens from 152 patients diagnosed with testicular cancer at Fredericia Hospital in Denmark from 2004 to 2014, and 106 patients diagnosed at St Thomas' Hospital in London from 2011 to 2015.

RESULTS: The Danish patients' median age was 37 years (range: 16-74 years) and the English patients' 36 years (range: 18-78 years). In the Danish patients, 29 (19.1%) had TML, and in the English patients, 43 (40.6%) had TML (p < 0.001). Haematoxylin bodies were slightly more common in the English patients. Laminated calcification was more often seen in seminomas than in non-seminomas.  CONCLUSIONS: The English testicular cancer patients had a statistically significantly higher TML prevalence than the Danish patients. This observation questions the hypothesised biological association between TML and testicular  cancer.

FUNDING: The Region of Southern Denmark supported this study.

TRIAL REGISTRATION: not relevant.

Original language	English
Journal	Danish Medical Journal
Volume	65
Issue number	3
ISSN	1603-9629
Publication status	Published - Mar 2018
Externally published	Yes

Bibliographical note

Articles published in the Danish Medical Journal are “open access”. This means that the articles are distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits any non-commercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

Keywords

Adolescent
Adult
Aged
Calculi/epidemiology
Denmark/epidemiology
Humans
Logistic Models
London/epidemiology
Male
Middle Aged
Multivariate Analysis
Precancerous Conditions/pathology
Prevalence
Testicular Diseases/epidemiology
Testicular Neoplasms/complications
Testis/pathology
Young Adult

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https://ugeskriftet.dk/dmj/testicular-microlithiasis-patients-testicular-cancer-united-kingdom-and-denmarkLicence: CC BY-NC 4.0

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Cite this

Pedersen, M. R., Horsfield, C., Foot, O., Lindebjerg, J., Osther, P. J. S., Vedsted, P., Chandra, A., Rafaelsen, S. R., & Møller, H. (2018). Testicular microlithiasis in patients with testicular cancer in the United Kingdom and in Denmark. Danish Medical Journal, 65(3). https://ugeskriftet.dk/dmj/testicular-microlithiasis-patients-testicular-cancer-united-kingdom-and-denmark

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title = "Testicular microlithiasis in patients with testicular cancer in the United Kingdom and in Denmark",

abstract = "INTRODUCTION: Testicular cancer is the most common type of cancer in young Caucasian men. It has been suggested that testicular microlithiasis (TML) is a premalignant condition. This study's objective was to investigate TML histology prevalence in testicular cancer patients in two European populations.METHODS: We analysed archived histopathology orchiectomy specimens from 152 patients diagnosed with testicular cancer at Fredericia Hospital in Denmark from 2004 to 2014, and 106 patients diagnosed at St Thomas' Hospital in London from 2011 to 2015.RESULTS: The Danish patients' median age was 37 years (range: 16-74 years) and the English patients' 36 years (range: 18-78 years). In the Danish patients, 29 (19.1%) had TML, and in the English patients, 43 (40.6%) had TML (p < 0.001). Haematoxylin bodies were slightly more common in the English patients. Laminated calcification was more often seen in seminomas than in non-seminomas.  CONCLUSIONS: The English testicular cancer patients had a statistically significantly higher TML prevalence than the Danish patients. This observation questions the hypothesised biological association between TML and testicular  cancer.FUNDING: The Region of Southern Denmark supported this study.TRIAL REGISTRATION: not relevant.",

keywords = "Adolescent, Adult, Aged, Calculi/epidemiology, Denmark/epidemiology, Humans, Logistic Models, London/epidemiology, Male, Middle Aged, Multivariate Analysis, Precancerous Conditions/pathology, Prevalence, Testicular Diseases/epidemiology, Testicular Neoplasms/complications, Testis/pathology, Young Adult",

author = "Pedersen, {Malene Roland} and Catherine Horsfield and Oliver Foot and Jan Lindebjerg and Osther, {Palle J{\o}rn Sloth} and Peter Vedsted and Ashish Chandra and Rafaelsen, {S{\o}ren Rafael} and Henrik M{\o}ller",

note = "Articles published in the Danish Medical Journal are “open access”. This means that the articles are distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits any non-commercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.",

year = "2018",

month = mar,

language = "English",

volume = "65",

journal = "Danish Medical Journal",

issn = "1603-9629",

publisher = "Almindelige Danske Laegeforening",

number = "3",

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Pedersen, MR, Horsfield, C, Foot, O, Lindebjerg, J, Osther, PJS, Vedsted, P, Chandra, A, Rafaelsen, SR & Møller, H 2018, 'Testicular microlithiasis in patients with testicular cancer in the United Kingdom and in Denmark', Danish Medical Journal, vol. 65, no. 3. <https://ugeskriftet.dk/dmj/testicular-microlithiasis-patients-testicular-cancer-united-kingdom-and-denmark>

TY - JOUR

T1 - Testicular microlithiasis in patients with testicular cancer in the United Kingdom and in Denmark

AU - Pedersen, Malene Roland

AU - Horsfield, Catherine

AU - Foot, Oliver

AU - Lindebjerg, Jan

AU - Osther, Palle Jørn Sloth

AU - Vedsted, Peter

AU - Chandra, Ashish

AU - Rafaelsen, Søren Rafael

AU - Møller, Henrik

N1 - Articles published in the Danish Medical Journal are “open access”. This means that the articles are distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits any non-commercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

PY - 2018/3

Y1 - 2018/3

N2 - INTRODUCTION: Testicular cancer is the most common type of cancer in young Caucasian men. It has been suggested that testicular microlithiasis (TML) is a premalignant condition. This study's objective was to investigate TML histology prevalence in testicular cancer patients in two European populations.METHODS: We analysed archived histopathology orchiectomy specimens from 152 patients diagnosed with testicular cancer at Fredericia Hospital in Denmark from 2004 to 2014, and 106 patients diagnosed at St Thomas' Hospital in London from 2011 to 2015.RESULTS: The Danish patients' median age was 37 years (range: 16-74 years) and the English patients' 36 years (range: 18-78 years). In the Danish patients, 29 (19.1%) had TML, and in the English patients, 43 (40.6%) had TML (p < 0.001). Haematoxylin bodies were slightly more common in the English patients. Laminated calcification was more often seen in seminomas than in non-seminomas.  CONCLUSIONS: The English testicular cancer patients had a statistically significantly higher TML prevalence than the Danish patients. This observation questions the hypothesised biological association between TML and testicular  cancer.FUNDING: The Region of Southern Denmark supported this study.TRIAL REGISTRATION: not relevant.

AB - INTRODUCTION: Testicular cancer is the most common type of cancer in young Caucasian men. It has been suggested that testicular microlithiasis (TML) is a premalignant condition. This study's objective was to investigate TML histology prevalence in testicular cancer patients in two European populations.METHODS: We analysed archived histopathology orchiectomy specimens from 152 patients diagnosed with testicular cancer at Fredericia Hospital in Denmark from 2004 to 2014, and 106 patients diagnosed at St Thomas' Hospital in London from 2011 to 2015.RESULTS: The Danish patients' median age was 37 years (range: 16-74 years) and the English patients' 36 years (range: 18-78 years). In the Danish patients, 29 (19.1%) had TML, and in the English patients, 43 (40.6%) had TML (p < 0.001). Haematoxylin bodies were slightly more common in the English patients. Laminated calcification was more often seen in seminomas than in non-seminomas.  CONCLUSIONS: The English testicular cancer patients had a statistically significantly higher TML prevalence than the Danish patients. This observation questions the hypothesised biological association between TML and testicular  cancer.FUNDING: The Region of Southern Denmark supported this study.TRIAL REGISTRATION: not relevant.

KW - Adolescent

KW - Adult

KW - Aged

KW - Calculi/epidemiology

KW - Denmark/epidemiology

KW - Humans

KW - Logistic Models

KW - London/epidemiology

KW - Male

KW - Middle Aged

KW - Multivariate Analysis

KW - Precancerous Conditions/pathology

KW - Prevalence

KW - Testicular Diseases/epidemiology

KW - Testicular Neoplasms/complications

KW - Testis/pathology

KW - Young Adult

M3 - Journal article

C2 - 29510806

SN - 1603-9629

VL - 65

JO - Danish Medical Journal

JF - Danish Medical Journal

IS - 3

ER -

Testicular microlithiasis in patients with testicular cancer in the United Kingdom and in Denmark

Abstract

Bibliographical note

Keywords

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AUB Link

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Cite this