The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers

Niklas Mattsson; Ulf Andreasson; Staffan Persson; Hiroyuki Arai; Sat Dev Batish; Sergio Bernardini; Luisella Bocchio-Chiavetto; Marinus A Blankenstein; Maria C Carrillo; Sonia Chalbot; Els Coart; Davide Chiasserini; Neal Cutler; Gunilla Dahlfors; Stefan Duller; Anne M Fagan; Orestes Forlenza; Giovanni B Frisoni; Douglas Galasko; Daniela Galimberti; Harald Hampel; Aase Handberg; Michael T Heneka; Adrianna Z Herskovits; Sanna-Kaisa Herukka; David M Holtzman; Christian Humpel; Bradley T Hyman; Khalid Iqbal; Mathias Jucker; Stephan A Kaeser; Elmar Kaiser; Elisabeth Kapaki; Daniel Kidd; Peter Klivenyi; Cindy S Knudsen; Markus P Kummer; James Lui; Albert Lladó; Piotr Lewczuk; Qiao-Xin Li; Ralph Martins; Colin Masters; John McAuliffe; Marc Mercken; Abhay Moghekar; José Luis Molinuevo; Thomas J Montine; William Nowatzke; Richard O'Brien; Markus Otto; George P Paraskevas; Lucilla Parnetti; Ronald C Petersen; David Prvulovic; Herman P M de Reus; Robert A Rissman; Elio Scarpini; Alessandro Stefani; Hilkka Soininen; Johannes Schröder; Leslie M Shaw; Anders Skinningsrud; Brith Skrogstad; Annette Spreer; Leda Talib; Charlotte Teunissen; John Q Trojanowski; Hayrettin Tumani; Robert M Umek; Bianca Van Broeck; Hugo Vanderstichele; Laszlo Vecsei; Marcel M Verbeek; Manfred Windisch; Jing Zhang; Henrik Zetterberg; Kaj Blennow

doi:10.1016/j.jalz.2011.05.2243

The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers

Niklas Mattsson, Ulf Andreasson, Staffan Persson, Hiroyuki Arai, Sat Dev Batish, Sergio Bernardini, Luisella Bocchio-Chiavetto, Marinus A Blankenstein, Maria C Carrillo, Sonia Chalbot, Els Coart, Davide Chiasserini, Neal Cutler, Gunilla Dahlfors, Stefan Duller, Anne M Fagan, Orestes Forlenza, Giovanni B Frisoni, Douglas Galasko, Daniela GalimbertiHarald Hampel, Aase Handberg, Michael T Heneka, Adrianna Z Herskovits, Sanna-Kaisa Herukka, David M Holtzman, Christian Humpel, Bradley T Hyman, Khalid Iqbal, Mathias Jucker, Stephan A Kaeser, Elmar Kaiser, Elisabeth Kapaki, Daniel Kidd, Peter Klivenyi, Cindy S Knudsen, Markus P Kummer, James Lui, Albert Lladó, Piotr Lewczuk, Qiao-Xin Li, Ralph Martins, Colin Masters, John McAuliffe, Marc Mercken, Abhay Moghekar, José Luis Molinuevo, Thomas J Montine, William Nowatzke, Richard O'Brien, Markus Otto, George P Paraskevas, Lucilla Parnetti, Ronald C Petersen, David Prvulovic, Herman P M de Reus, Robert A Rissman, Elio Scarpini, Alessandro Stefani, Hilkka Soininen, Johannes Schröder, Leslie M Shaw, Anders Skinningsrud, Brith Skrogstad, Annette Spreer, Leda Talib, Charlotte Teunissen, John Q Trojanowski, Hayrettin Tumani, Robert M Umek, Bianca Van Broeck, Hugo Vanderstichele, Laszlo Vecsei, Marcel M Verbeek, Manfred Windisch, Jing Zhang, Henrik Zetterberg, Kaj Blennow

Research output: Contribution to journal › Journal article › Research › peer-review

345 Citations (Scopus)

Abstract

The cerebrospinal fluid (CSF) biomarkers amyloid β (Aβ)-42, total-tau (T-tau), and phosphorylated-tau (P-tau) demonstrate good diagnostic accuracy for Alzheimer's disease (AD). However, there are large variations in biomarker measurements between studies, and between and within laboratories. The Alzheimer's Association has initiated a global quality control program to estimate and monitor variability of measurements, quantify batch-to-batch assay variations, and identify sources of variability. In this article, we present the results from the first two rounds of the program.

Original language	English
Journal	Alzheimer's & Dementia
Volume	7
Pages (from-to)	386-395.e6
Number of pages	10
ISSN	1552-5260
DOIs	https://doi.org/10.1016/j.jalz.2011.05.2243
Publication status	Published - 2011
Externally published	Yes

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Mattsson, N., Andreasson, U., Persson, S., Arai, H., Batish, S. D., Bernardini, S., Bocchio-Chiavetto, L., Blankenstein, M. A., Carrillo, M. C., Chalbot, S., Coart, E., Chiasserini, D., Cutler, N., Dahlfors, G., Duller, S., Fagan, A. M., Forlenza, O., Frisoni, G. B., Galasko, D., ... Blennow, K. (2011). The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers. Alzheimer's & Dementia, 7, 386-395.e6. https://doi.org/10.1016/j.jalz.2011.05.2243

@article{48d883b7687140c78a9c4e3b58bbf156,

title = "The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers",

abstract = "The cerebrospinal fluid (CSF) biomarkers amyloid β (Aβ)-42, total-tau (T-tau), and phosphorylated-tau (P-tau) demonstrate good diagnostic accuracy for Alzheimer's disease (AD). However, there are large variations in biomarker measurements between studies, and between and within laboratories. The Alzheimer's Association has initiated a global quality control program to estimate and monitor variability of measurements, quantify batch-to-batch assay variations, and identify sources of variability. In this article, we present the results from the first two rounds of the program.",

author = "Niklas Mattsson and Ulf Andreasson and Staffan Persson and Hiroyuki Arai and Batish, {Sat Dev} and Sergio Bernardini and Luisella Bocchio-Chiavetto and Blankenstein, {Marinus A} and Carrillo, {Maria C} and Sonia Chalbot and Els Coart and Davide Chiasserini and Neal Cutler and Gunilla Dahlfors and Stefan Duller and Fagan, {Anne M} and Orestes Forlenza and Frisoni, {Giovanni B} and Douglas Galasko and Daniela Galimberti and Harald Hampel and Aase Handberg and Heneka, {Michael T} and Herskovits, {Adrianna Z} and Sanna-Kaisa Herukka and Holtzman, {David M} and Christian Humpel and Hyman, {Bradley T} and Khalid Iqbal and Mathias Jucker and Kaeser, {Stephan A} and Elmar Kaiser and Elisabeth Kapaki and Daniel Kidd and Peter Klivenyi and Knudsen, {Cindy S} and Kummer, {Markus P} and James Lui and Albert Llad{\'o} and Piotr Lewczuk and Qiao-Xin Li and Ralph Martins and Colin Masters and John McAuliffe and Marc Mercken and Abhay Moghekar and Molinuevo, {Jos{\'e} Luis} and Montine, {Thomas J} and William Nowatzke and Richard O'Brien and Markus Otto and Paraskevas, {George P} and Lucilla Parnetti and Petersen, {Ronald C} and David Prvulovic and {de Reus}, {Herman P M} and Rissman, {Robert A} and Elio Scarpini and Alessandro Stefani and Hilkka Soininen and Johannes Schr{\"o}der and Shaw, {Leslie M} and Anders Skinningsrud and Brith Skrogstad and Annette Spreer and Leda Talib and Charlotte Teunissen and Trojanowski, {John Q} and Hayrettin Tumani and Umek, {Robert M} and {Van Broeck}, Bianca and Hugo Vanderstichele and Laszlo Vecsei and Verbeek, {Marcel M} and Manfred Windisch and Jing Zhang and Henrik Zetterberg and Kaj Blennow",

year = "2011",

doi = "10.1016/j.jalz.2011.05.2243",

language = "English",

volume = "7",

pages = "386--395.e6",

journal = "Alzheimer's & Dementia",

issn = "1552-5260",

publisher = "Elsevier",

}

Mattsson, N, Andreasson, U, Persson, S, Arai, H, Batish, SD, Bernardini, S, Bocchio-Chiavetto, L, Blankenstein, MA, Carrillo, MC, Chalbot, S, Coart, E, Chiasserini, D, Cutler, N, Dahlfors, G, Duller, S, Fagan, AM, Forlenza, O, Frisoni, GB, Galasko, D, Galimberti, D, Hampel, H, Handberg, A, Heneka, MT, Herskovits, AZ, Herukka, S-K, Holtzman, DM, Humpel, C, Hyman, BT, Iqbal, K, Jucker, M, Kaeser, SA, Kaiser, E, Kapaki, E, Kidd, D, Klivenyi, P, Knudsen, CS, Kummer, MP, Lui, J, Lladó, A, Lewczuk, P, Li, Q-X, Martins, R, Masters, C, McAuliffe, J, Mercken, M, Moghekar, A, Molinuevo, JL, Montine, TJ, Nowatzke, W, O'Brien, R, Otto, M, Paraskevas, GP, Parnetti, L, Petersen, RC, Prvulovic, D, de Reus, HPM, Rissman, RA, Scarpini, E, Stefani, A, Soininen, H, Schröder, J, Shaw, LM, Skinningsrud, A, Skrogstad, B, Spreer, A, Talib, L, Teunissen, C, Trojanowski, JQ, Tumani, H, Umek, RM, Van Broeck, B, Vanderstichele, H, Vecsei, L, Verbeek, MM, Windisch, M, Zhang, J, Zetterberg, H & Blennow, K 2011, 'The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers', Alzheimer's & Dementia, vol. 7, pp. 386-395.e6. https://doi.org/10.1016/j.jalz.2011.05.2243

TY - JOUR

T1 - The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers

AU - Mattsson, Niklas

AU - Andreasson, Ulf

AU - Persson, Staffan

AU - Arai, Hiroyuki

AU - Batish, Sat Dev

AU - Bernardini, Sergio

AU - Bocchio-Chiavetto, Luisella

AU - Blankenstein, Marinus A

AU - Carrillo, Maria C

AU - Chalbot, Sonia

AU - Coart, Els

AU - Chiasserini, Davide

AU - Cutler, Neal

AU - Dahlfors, Gunilla

AU - Duller, Stefan

AU - Fagan, Anne M

AU - Forlenza, Orestes

AU - Frisoni, Giovanni B

AU - Galasko, Douglas

AU - Galimberti, Daniela

AU - Hampel, Harald

AU - Handberg, Aase

AU - Heneka, Michael T

AU - Herskovits, Adrianna Z

AU - Herukka, Sanna-Kaisa

AU - Holtzman, David M

AU - Humpel, Christian

AU - Hyman, Bradley T

AU - Iqbal, Khalid

AU - Jucker, Mathias

AU - Kaeser, Stephan A

AU - Kaiser, Elmar

AU - Kapaki, Elisabeth

AU - Kidd, Daniel

AU - Klivenyi, Peter

AU - Knudsen, Cindy S

AU - Kummer, Markus P

AU - Lui, James

AU - Lladó, Albert

AU - Lewczuk, Piotr

AU - Li, Qiao-Xin

AU - Martins, Ralph

AU - Masters, Colin

AU - McAuliffe, John

AU - Mercken, Marc

AU - Moghekar, Abhay

AU - Molinuevo, José Luis

AU - Montine, Thomas J

AU - Nowatzke, William

AU - O'Brien, Richard

AU - Otto, Markus

AU - Paraskevas, George P

AU - Parnetti, Lucilla

AU - Petersen, Ronald C

AU - Prvulovic, David

AU - de Reus, Herman P M

AU - Rissman, Robert A

AU - Scarpini, Elio

AU - Stefani, Alessandro

AU - Soininen, Hilkka

AU - Schröder, Johannes

AU - Shaw, Leslie M

AU - Skinningsrud, Anders

AU - Skrogstad, Brith

AU - Spreer, Annette

AU - Talib, Leda

AU - Teunissen, Charlotte

AU - Trojanowski, John Q

AU - Tumani, Hayrettin

AU - Umek, Robert M

AU - Van Broeck, Bianca

AU - Vanderstichele, Hugo

AU - Vecsei, Laszlo

AU - Verbeek, Marcel M

AU - Windisch, Manfred

AU - Zhang, Jing

AU - Zetterberg, Henrik

AU - Blennow, Kaj

PY - 2011

Y1 - 2011

N2 - The cerebrospinal fluid (CSF) biomarkers amyloid β (Aβ)-42, total-tau (T-tau), and phosphorylated-tau (P-tau) demonstrate good diagnostic accuracy for Alzheimer's disease (AD). However, there are large variations in biomarker measurements between studies, and between and within laboratories. The Alzheimer's Association has initiated a global quality control program to estimate and monitor variability of measurements, quantify batch-to-batch assay variations, and identify sources of variability. In this article, we present the results from the first two rounds of the program.

AB - The cerebrospinal fluid (CSF) biomarkers amyloid β (Aβ)-42, total-tau (T-tau), and phosphorylated-tau (P-tau) demonstrate good diagnostic accuracy for Alzheimer's disease (AD). However, there are large variations in biomarker measurements between studies, and between and within laboratories. The Alzheimer's Association has initiated a global quality control program to estimate and monitor variability of measurements, quantify batch-to-batch assay variations, and identify sources of variability. In this article, we present the results from the first two rounds of the program.

U2 - 10.1016/j.jalz.2011.05.2243

DO - 10.1016/j.jalz.2011.05.2243

M3 - Journal article

SN - 1552-5260

VL - 7

SP - 386-395.e6

JO - Alzheimer's & Dementia

JF - Alzheimer's & Dementia

ER -

The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers

Abstract

Bibliographical note

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