The association between self-reported health status and adverse events: a comparison among coronary artery bypass grafting (CABG) versus percutaneous coronary intervention (PCI)

Stine Nørris Nielsen; Trine Bernholdt Rasmussen; Jens Flensted Lassen; Selina Kikkenborg Berg; Lars Thrysoee; Jacob Eifer Møller; Lisette Okkels Jensen; Anne Langhoff Thuesen; Anne Vinggaard Christensen; Ola Ekholm; Rikke Mols; Charlotte Brun Thorup; Britt Borregaard

doi:10.1007/s11136-020-02573-8

The association between self-reported health status and adverse events: a comparison among coronary artery bypass grafting (CABG) versus percutaneous coronary intervention (PCI)

Stine Nørris Nielsen, Trine Bernholdt Rasmussen, Jens Flensted Lassen, Selina Kikkenborg Berg, Lars Thrysoee, Jacob Eifer Møller, Lisette Okkels Jensen, Anne Langhoff Thuesen, Anne Vinggaard Christensen, Ola Ekholm, Rikke Mols, Charlotte Brun Thorup, Britt Borregaard

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

PURPOSE: While several studies have investigated clinical outcomes following coronary artery bypass grafting (CABG) vs. percutaneous coronary intervention (PCI), studies investigating self-reported health and the association with adverse outcomes are limited. Thus, the aim was to investigate differences in health-related quality of life (HRQoL), anxiety and depression at discharge and the association with a composite endpoint of the first event of acute cardiac readmission, revascularisation or 1-year mortality among patients undergoing CABG vs. PCI.

METHODS: Data from the national cohort study, DenHeart, were used, including measures of HRQoL; EuroQoL-5D-5L (EQ-5D Index Score and VAS) and HeartQoL (Global, Physical and Emotional), anxiety and depression (Hospital Anxiety and Depression Scale, HADS) and register-based follow-up. A total of 7000 patients were included (CABG n = 652, PCI n = 6348) (median age 65, 75% men). Cox Proportional Hazard models were performed among a propensity-matched population of responders (n = 520).

RESULTS: HRQoL was significantly better among patients undergoing PCI vs. CABG, but with no differences in time to readmission or revascularisation. HRQoL, anxiety and depression were significantly associated with the risk of the composite endpoint among the PCI group (Hazard Ratio, HR (95% confidence intervals, CI) [EQ-5D index score 3.07 (1.67-5.67), EQ-5D VAS 0.97 (0.96-0.99), HeartQol Global 0.61 (0.38-0.95), HeartQol Emotional 0.56 (0.39-0.80), HADS-D ≥ 8 3.12 (1.61-6.01), HADS-A ≥ 8 2.08 (1.14-3.80)].

CONCLUSION: Patients undergoing PCI reported better HRQoL at discharge compared with patients undergoing CABG, whereas readmission rates were similar. Self-reported health was associated with the risk of adverse events among patients undergoing PCI, but not among patients undergoing CABG.

CLINICAL TRIAL REGISTRATION: NCT01926145.

Original language	English
Journal	Quality of Life Research
Volume	29
Issue number	11
Pages (from-to)	3017-3029
Number of pages	13
ISSN	0962-9343
DOIs	https://doi.org/10.1007/s11136-020-02573-8
Publication status	Published - Nov 2020

Keywords

Anxiety
Cardiac readmission
Coronary artery bypass grafting
Depression
Percutaneous coronary intervention
Quality of life

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Nielsen, S. N., Rasmussen, T. B., Lassen, J. F., Berg, S. K., Thrysoee, L., Møller, J. E., Jensen, L. O., Thuesen, A. L., Christensen, A. V., Ekholm, O., Mols, R., Thorup, C. B., & Borregaard, B. (2020). The association between self-reported health status and adverse events: a comparison among coronary artery bypass grafting (CABG) versus percutaneous coronary intervention (PCI). Quality of Life Research, 29(11), 3017-3029. Advance online publication. https://doi.org/10.1007/s11136-020-02573-8

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title = "The association between self-reported health status and adverse events: a comparison among coronary artery bypass grafting (CABG) versus percutaneous coronary intervention (PCI)",

abstract = "PURPOSE: While several studies have investigated clinical outcomes following coronary artery bypass grafting (CABG) vs. percutaneous coronary intervention (PCI), studies investigating self-reported health and the association with adverse outcomes are limited. Thus, the aim was to investigate differences in health-related quality of life (HRQoL), anxiety and depression at discharge and the association with a composite endpoint of the first event of acute cardiac readmission, revascularisation or 1-year mortality among patients undergoing CABG vs. PCI.METHODS: Data from the national cohort study, DenHeart, were used, including measures of HRQoL; EuroQoL-5D-5L (EQ-5D Index Score and VAS) and HeartQoL (Global, Physical and Emotional), anxiety and depression (Hospital Anxiety and Depression Scale, HADS) and register-based follow-up. A total of 7000 patients were included (CABG n = 652, PCI n = 6348) (median age 65, 75% men). Cox Proportional Hazard models were performed among a propensity-matched population of responders (n = 520).RESULTS: HRQoL was significantly better among patients undergoing PCI vs. CABG, but with no differences in time to readmission or revascularisation. HRQoL, anxiety and depression were significantly associated with the risk of the composite endpoint among the PCI group (Hazard Ratio, HR (95% confidence intervals, CI) [EQ-5D index score 3.07 (1.67-5.67), EQ-5D VAS 0.97 (0.96-0.99), HeartQol Global 0.61 (0.38-0.95), HeartQol Emotional 0.56 (0.39-0.80), HADS-D ≥ 8 3.12 (1.61-6.01), HADS-A ≥ 8 2.08 (1.14-3.80)].CONCLUSION: Patients undergoing PCI reported better HRQoL at discharge compared with patients undergoing CABG, whereas readmission rates were similar. Self-reported health was associated with the risk of adverse events among patients undergoing PCI, but not among patients undergoing CABG.CLINICAL TRIAL REGISTRATION: NCT01926145.",

keywords = "Anxiety, Cardiac readmission, Coronary artery bypass grafting, Depression, Percutaneous coronary intervention, Quality of life",

author = "Nielsen, {Stine N{\o}rris} and Rasmussen, {Trine Bernholdt} and Lassen, {Jens Flensted} and Berg, {Selina Kikkenborg} and Lars Thrysoee and M{\o}ller, {Jacob Eifer} and Jensen, {Lisette Okkels} and Thuesen, {Anne Langhoff} and Christensen, {Anne Vinggaard} and Ola Ekholm and Rikke Mols and Thorup, {Charlotte Brun} and Britt Borregaard",

year = "2020",

month = nov,

doi = "10.1007/s11136-020-02573-8",

language = "English",

volume = "29",

pages = "3017--3029",

journal = "Quality of Life Research",

issn = "0962-9343",

publisher = "Springer",

number = "11",

}

Nielsen, SN, Rasmussen, TB, Lassen, JF, Berg, SK, Thrysoee, L, Møller, JE, Jensen, LO, Thuesen, AL, Christensen, AV, Ekholm, O, Mols, R, Thorup, CB & Borregaard, B 2020, 'The association between self-reported health status and adverse events: a comparison among coronary artery bypass grafting (CABG) versus percutaneous coronary intervention (PCI)', Quality of Life Research, vol. 29, no. 11, pp. 3017-3029. https://doi.org/10.1007/s11136-020-02573-8

The association between self-reported health status and adverse events: a comparison among coronary artery bypass grafting (CABG) versus percutaneous coronary intervention (PCI). / Nielsen, Stine Nørris; Rasmussen, Trine Bernholdt; Lassen, Jens Flensted et al.
In: Quality of Life Research, Vol. 29, No. 11, 11.2020, p. 3017-3029.

Research output: Contribution to journal › Journal article › Research › peer-review

TY - JOUR

T1 - The association between self-reported health status and adverse events

T2 - a comparison among coronary artery bypass grafting (CABG) versus percutaneous coronary intervention (PCI)

AU - Nielsen, Stine Nørris

AU - Rasmussen, Trine Bernholdt

AU - Lassen, Jens Flensted

AU - Berg, Selina Kikkenborg

AU - Thrysoee, Lars

AU - Møller, Jacob Eifer

AU - Jensen, Lisette Okkels

AU - Thuesen, Anne Langhoff

AU - Christensen, Anne Vinggaard

AU - Ekholm, Ola

AU - Mols, Rikke

AU - Thorup, Charlotte Brun

AU - Borregaard, Britt

PY - 2020/11

Y1 - 2020/11

N2 - PURPOSE: While several studies have investigated clinical outcomes following coronary artery bypass grafting (CABG) vs. percutaneous coronary intervention (PCI), studies investigating self-reported health and the association with adverse outcomes are limited. Thus, the aim was to investigate differences in health-related quality of life (HRQoL), anxiety and depression at discharge and the association with a composite endpoint of the first event of acute cardiac readmission, revascularisation or 1-year mortality among patients undergoing CABG vs. PCI.METHODS: Data from the national cohort study, DenHeart, were used, including measures of HRQoL; EuroQoL-5D-5L (EQ-5D Index Score and VAS) and HeartQoL (Global, Physical and Emotional), anxiety and depression (Hospital Anxiety and Depression Scale, HADS) and register-based follow-up. A total of 7000 patients were included (CABG n = 652, PCI n = 6348) (median age 65, 75% men). Cox Proportional Hazard models were performed among a propensity-matched population of responders (n = 520).RESULTS: HRQoL was significantly better among patients undergoing PCI vs. CABG, but with no differences in time to readmission or revascularisation. HRQoL, anxiety and depression were significantly associated with the risk of the composite endpoint among the PCI group (Hazard Ratio, HR (95% confidence intervals, CI) [EQ-5D index score 3.07 (1.67-5.67), EQ-5D VAS 0.97 (0.96-0.99), HeartQol Global 0.61 (0.38-0.95), HeartQol Emotional 0.56 (0.39-0.80), HADS-D ≥ 8 3.12 (1.61-6.01), HADS-A ≥ 8 2.08 (1.14-3.80)].CONCLUSION: Patients undergoing PCI reported better HRQoL at discharge compared with patients undergoing CABG, whereas readmission rates were similar. Self-reported health was associated with the risk of adverse events among patients undergoing PCI, but not among patients undergoing CABG.CLINICAL TRIAL REGISTRATION: NCT01926145.

AB - PURPOSE: While several studies have investigated clinical outcomes following coronary artery bypass grafting (CABG) vs. percutaneous coronary intervention (PCI), studies investigating self-reported health and the association with adverse outcomes are limited. Thus, the aim was to investigate differences in health-related quality of life (HRQoL), anxiety and depression at discharge and the association with a composite endpoint of the first event of acute cardiac readmission, revascularisation or 1-year mortality among patients undergoing CABG vs. PCI.METHODS: Data from the national cohort study, DenHeart, were used, including measures of HRQoL; EuroQoL-5D-5L (EQ-5D Index Score and VAS) and HeartQoL (Global, Physical and Emotional), anxiety and depression (Hospital Anxiety and Depression Scale, HADS) and register-based follow-up. A total of 7000 patients were included (CABG n = 652, PCI n = 6348) (median age 65, 75% men). Cox Proportional Hazard models were performed among a propensity-matched population of responders (n = 520).RESULTS: HRQoL was significantly better among patients undergoing PCI vs. CABG, but with no differences in time to readmission or revascularisation. HRQoL, anxiety and depression were significantly associated with the risk of the composite endpoint among the PCI group (Hazard Ratio, HR (95% confidence intervals, CI) [EQ-5D index score 3.07 (1.67-5.67), EQ-5D VAS 0.97 (0.96-0.99), HeartQol Global 0.61 (0.38-0.95), HeartQol Emotional 0.56 (0.39-0.80), HADS-D ≥ 8 3.12 (1.61-6.01), HADS-A ≥ 8 2.08 (1.14-3.80)].CONCLUSION: Patients undergoing PCI reported better HRQoL at discharge compared with patients undergoing CABG, whereas readmission rates were similar. Self-reported health was associated with the risk of adverse events among patients undergoing PCI, but not among patients undergoing CABG.CLINICAL TRIAL REGISTRATION: NCT01926145.

KW - Anxiety

KW - Cardiac readmission

KW - Coronary artery bypass grafting

KW - Depression

KW - Percutaneous coronary intervention

KW - Quality of life

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U2 - 10.1007/s11136-020-02573-8

DO - 10.1007/s11136-020-02573-8

M3 - Journal article

C2 - 32857268

SN - 0962-9343

VL - 29

SP - 3017

EP - 3029

JO - Quality of Life Research

JF - Quality of Life Research

IS - 11

ER -