TY - JOUR
T1 - The Autonomic Nervous System and Cardiovascular Disease
T2 - Role of n-3 PUFAs
AU - La Rovere, Maria Teresa
AU - Christensen, Jeppe Hagstrup
N1 - Copyright © 2015. Published by Elsevier Inc.
PY - 2015
Y1 - 2015
N2 - In the last decades, a large body of experimental and clinical evidence has been accumulated showing that cardiovascular diseases are often accompanied by an imbalance in the sympathetic-vagal outflow to the heart, resulting in a chronic adrenergic activation. The arterial baroreceptor system is a key component of mechanisms contributing to the neural regulation of the cardiovascular system. Several methods have been proposed to assess autonomic activity by analyzing heart rate and blood pressure changes either spontaneously occurring or following provocations. The autonomic nervous system has been regarded as one of the putative mechanisms involved into the beneficial effects of exposure to n-3 fatty acids observed in epidemiological studies. The aim of the present review is to provide an update on the clinical evidence proposed so far linking exposure to n-3 fatty acids to autonomic nervous system modulation.
AB - In the last decades, a large body of experimental and clinical evidence has been accumulated showing that cardiovascular diseases are often accompanied by an imbalance in the sympathetic-vagal outflow to the heart, resulting in a chronic adrenergic activation. The arterial baroreceptor system is a key component of mechanisms contributing to the neural regulation of the cardiovascular system. Several methods have been proposed to assess autonomic activity by analyzing heart rate and blood pressure changes either spontaneously occurring or following provocations. The autonomic nervous system has been regarded as one of the putative mechanisms involved into the beneficial effects of exposure to n-3 fatty acids observed in epidemiological studies. The aim of the present review is to provide an update on the clinical evidence proposed so far linking exposure to n-3 fatty acids to autonomic nervous system modulation.
U2 - 10.1016/j.vph.2015.02.005
DO - 10.1016/j.vph.2015.02.005
M3 - Review article
C2 - 25869497
SN - 1537-1891
VL - 71
SP - 1
EP - 10
JO - Vascular Pharmacology
JF - Vascular Pharmacology
ER -