The B1-cell subpopulation is diminished in patients with relapsing-remitting multiple sclerosis

Caroline Tørring; Charlotte Christie Petersen; Lasse Bjerg; Emil Kofod-Olsen; Thor Petersen; Per Höllsberg

doi:10.1016/j.jneuroim.2013.06.002

The B1-cell subpopulation is diminished in patients with relapsing-remitting multiple sclerosis

Caroline Tørring, Charlotte Christie Petersen, Lasse Bjerg, Emil Kofod-Olsen, Thor Petersen, Per Höllsberg

Research output: Contribution to journal › Journal article › Research › peer-review

25 Citations (Scopus)

Abstract

B cell subsets in newly diagnosed untreated, relapsing-remitting multiple sclerosis (MS) patients were examined. The fraction of CD20(+) B cells was significantly increased in MS. Among subsets of B cells, MS patients had increased frequency of naïve cells, but reduced frequency of memory and B1 cells. The frequencies of B1 cells were inversely correlated with the time since last attack. B1 cells resembled the phenotype of either lymphocytes (CD11b(-) B1 cells) or monocytes (CD11b(+) B1 cells) and a small fraction of cells was CD3(+)CD20(+) by confocal microscopy.

Original language	English
Journal	Journal of Neuroimmunology
Volume	262
Issue number	1-2
Pages (from-to)	92-9
Number of pages	8
ISSN	0165-5728
DOIs	https://doi.org/10.1016/j.jneuroim.2013.06.002
Publication status	Published - 15 Sept 2013
Externally published	Yes

Keywords

Adult
Antigens, CD20
Antigens, CD3
B-Lymphocyte Subsets
Down-Regulation
Female
Humans
Immunophenotyping
Lymphocyte Count
Male
Multiple Sclerosis, Relapsing-Remitting
Up-Regulation

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title = "The B1-cell subpopulation is diminished in patients with relapsing-remitting multiple sclerosis",

abstract = "B cell subsets in newly diagnosed untreated, relapsing-remitting multiple sclerosis (MS) patients were examined. The fraction of CD20(+) B cells was significantly increased in MS. Among subsets of B cells, MS patients had increased frequency of na{\"i}ve cells, but reduced frequency of memory and B1 cells. The frequencies of B1 cells were inversely correlated with the time since last attack. B1 cells resembled the phenotype of either lymphocytes (CD11b(-) B1 cells) or monocytes (CD11b(+) B1 cells) and a small fraction of cells was CD3(+)CD20(+) by confocal microscopy.",

keywords = "Adult, Antigens, CD20, Antigens, CD3, B-Lymphocyte Subsets, Down-Regulation, Female, Humans, Immunophenotyping, Lymphocyte Count, Male, Multiple Sclerosis, Relapsing-Remitting, Up-Regulation",

author = "Caroline T{\o}rring and Petersen, {Charlotte Christie} and Lasse Bjerg and Emil Kofod-Olsen and Thor Petersen and Per H{\"o}llsberg",

year = "2013",

month = sep,

day = "15",

doi = "10.1016/j.jneuroim.2013.06.002",

language = "English",

volume = "262",

pages = "92--9",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

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number = "1-2",

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TY - JOUR

T1 - The B1-cell subpopulation is diminished in patients with relapsing-remitting multiple sclerosis

AU - Tørring, Caroline

AU - Petersen, Charlotte Christie

AU - Bjerg, Lasse

AU - Kofod-Olsen, Emil

AU - Petersen, Thor

AU - Höllsberg, Per

PY - 2013/9/15

Y1 - 2013/9/15

N2 - B cell subsets in newly diagnosed untreated, relapsing-remitting multiple sclerosis (MS) patients were examined. The fraction of CD20(+) B cells was significantly increased in MS. Among subsets of B cells, MS patients had increased frequency of naïve cells, but reduced frequency of memory and B1 cells. The frequencies of B1 cells were inversely correlated with the time since last attack. B1 cells resembled the phenotype of either lymphocytes (CD11b(-) B1 cells) or monocytes (CD11b(+) B1 cells) and a small fraction of cells was CD3(+)CD20(+) by confocal microscopy.

AB - B cell subsets in newly diagnosed untreated, relapsing-remitting multiple sclerosis (MS) patients were examined. The fraction of CD20(+) B cells was significantly increased in MS. Among subsets of B cells, MS patients had increased frequency of naïve cells, but reduced frequency of memory and B1 cells. The frequencies of B1 cells were inversely correlated with the time since last attack. B1 cells resembled the phenotype of either lymphocytes (CD11b(-) B1 cells) or monocytes (CD11b(+) B1 cells) and a small fraction of cells was CD3(+)CD20(+) by confocal microscopy.

KW - Adult

KW - Antigens, CD20

KW - Antigens, CD3

KW - B-Lymphocyte Subsets

KW - Down-Regulation

KW - Female

KW - Humans

KW - Immunophenotyping

KW - Lymphocyte Count

KW - Male

KW - Multiple Sclerosis, Relapsing-Remitting

KW - Up-Regulation

U2 - 10.1016/j.jneuroim.2013.06.002

DO - 10.1016/j.jneuroim.2013.06.002

M3 - Journal article

C2 - 23856341

SN - 0165-5728

VL - 262

SP - 92

EP - 99

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

The B1-cell subpopulation is diminished in patients with relapsing-remitting multiple sclerosis

Abstract

Keywords

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