The changing landscape of acromegaly - an epidemiological perspective

Christian Rosendal*, Mai Christiansen Arlien-Søborg, Eigil Husted Nielsen, Marianne Skovsager Andersen, Claus Larsen Feltoft, Caroline Kistorp, Olaf M. Dekkers, Jens Otto Lunde Jørgensen, Jakob Dal

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)


Acromegaly is a rare disease and thus challenging to accurately quantify epidemiologically. In this comprehensive literature review, we compare different approaches to studying acromegaly from an epidemiological perspective and describe the temporal evolution of the disease pertaining to epidemiological variables, clinical presentation and mortality. We present updated epidemiological data from the population-based Danish cohort of patients with acromegaly (AcroDEN), along with meta-analyses of existing estimates from around the world.Based on this, we conclude that the incidence, prevalence and age at acromegaly diagnosis are all steadily increasing, but with considerable variation between studies. An increased number of incidental cases may contribute to the increase in incidence and age at diagnosis, respectively. The clinical features at presentation are trending toward a milder disease phenotype at diagnosis, and advances in therapeutic options have reduced the mortality of patients with acromegaly to a level similar to that of the general population. Moreover, the underlying cause of death has shifted from cardiovascular to malignant neoplastic diseases.

Original languageEnglish
JournalReviews in endocrine & metabolic disorders
Publication statusE-pub ahead of print - 10 Feb 2024

Bibliographical note

© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.


  • Acromegaly
  • Epidemiology
  • Incidence
  • Mortality
  • Prevalence
  • Sex differences


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