The Efficacy of a Real-Time vs an Offline Associative Brain-Computer-Interface

N. Mrachacz-Kersting*, S. Aliakbaryhosseinabadi, N. Jiang, D. Farina

*Corresponding author

Research output: Contribution to book/anthology/report/conference proceedingArticle in proceedingResearchpeer-review


An associative brain-computer-interface (BCI) that correlates a peripherally generated afferent volley with the peak negativity (PN) of the movement related cortical potential (MRCP) induces plastic changes in the human motor cortex. The aim of the current study was to compare the effectiveness of this intervention when the MRCP PN time is pre-determined from a training data set (BCIoffline), or detected online (BCIonline). Ten healthy participants completed both interventions in randomized order. The mean peak-to-peak motor evoked potential (MEP) amplitudes were significantly larger 30 min after (277 ± 72 µV) the BCI interventions compared to pre-intervention MEPs (233 ± 64 µV) regardless of intervention type and stimulation intensity (p = 0.029). These results provide further strong support for the associative nature of the associative BCI but also suggest that they likely differ to the associative long-term potentiation protocol they were modelled on in the exact sites of plasticity.

Original languageEnglish
Title of host publicationConverging Clinical and Engineering Research on Neurorehabilitation III : Proceedings of the 4th International Conference on NeuroRehabilitation (ICNR2018), October 16-20, 2018, Pisa, Italy
Number of pages4
Publication date2019
ISBN (Print)978-3-030-01844-3
ISBN (Electronic)978-3-030-01845-0
Publication statusPublished - 2019
Event4th International Conference on NeuroRehabilitation, ICNR2018 - Pisa, Italy
Duration: 16 Oct 201820 Oct 2018


Conference4th International Conference on NeuroRehabilitation, ICNR2018
SeriesBiosystems and Biorobotics

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