The Etiology of Multiple Sclerosis: Genetic Evidence for the Involvement of the Human Endogenous Retrovirus HERV-Fc1

Bjørn Andersen Nexø; Tove Christensen; Jette Frederiksen; Anné Møller-Larsen; Annette Bang Oturai; Palle Villesen; Bettina Hansen; Kari K Nissen; Magdalena J Laska; Trine Skov Petersen; Sandra Bonnesen; Anne Hedemand; Tingting Wu; Xinjie Wang; Xiuqing Zhang; Tomasz Brudek; Romana Maric; Helle Søndergaard; Finn Thorup Sellebjerg; Klaus Brusgaard; Anders L Kjeldbjerg; Henrik B Rasmussen; Anders L Nielsen; Mette Nyegaard; Thor Petersen; Anders D Børglum; Finn S Pedersen

doi:10.1371/journal.pone.0016652

The Etiology of Multiple Sclerosis: Genetic Evidence for the Involvement of the Human Endogenous Retrovirus HERV-Fc1

Bjørn Andersen Nexø, Tove Christensen, Jette Frederiksen, Anné Møller-Larsen, Annette Bang Oturai, Palle Villesen, Bettina Hansen, Kari K Nissen, Magdalena J Laska, Trine Skov Petersen, Sandra Bonnesen, Anne Hedemand, Tingting Wu, Xinjie Wang, Xiuqing Zhang, Tomasz Brudek, Romana Maric, Helle Søndergaard, Finn Thorup Sellebjerg, Klaus BrusgaardAnders L Kjeldbjerg, Henrik B Rasmussen, Anders L Nielsen, Mette Nyegaard, Thor Petersen, Anders D Børglum, Finn S Pedersen

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

We have investigated the role of human endogenous retroviruses in multiple sclerosis by analyzing the DNA of patients and controls in 4 cohorts for associations between multiple sclerosis and polymorphisms near viral restriction genes or near endogenous retroviral loci with one or more intact or almost-intact genes. We found that SNPs in the gene TRIM5 were inversely correlated with disease. Conversely, SNPs around one retroviral locus, HERV-Fc1, showed a highly significant association with disease. The latter association was limited to a narrow region that contains no other known genes. We conclude that HERV-Fc1 and TRIM5 play a role in the etiology of multiple sclerosis. If these results are confirmed, they point to new modes of treatment for multiple sclerosis.

Original language	English
Journal	P L o S One
Volume	6
Issue number	2
Pages (from-to)	e16652
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0016652
Publication status	Published - 1 Jan 2011
Externally published	Yes

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Nexø, B. A., Christensen, T., Frederiksen, J., Møller-Larsen, A., Oturai, A. B., Villesen, P., Hansen, B., Nissen, K. K., Laska, M. J., Petersen, T. S., Bonnesen, S., Hedemand, A., Wu, T., Wang, X., Zhang, X., Brudek, T., Maric, R., Søndergaard, H., Sellebjerg, F. T., ... Pedersen, F. S. (2011). The Etiology of Multiple Sclerosis: Genetic Evidence for the Involvement of the Human Endogenous Retrovirus HERV-Fc1. P L o S One, 6(2), e16652. https://doi.org/10.1371/journal.pone.0016652

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title = "The Etiology of Multiple Sclerosis: Genetic Evidence for the Involvement of the Human Endogenous Retrovirus HERV-Fc1",

abstract = "We have investigated the role of human endogenous retroviruses in multiple sclerosis by analyzing the DNA of patients and controls in 4 cohorts for associations between multiple sclerosis and polymorphisms near viral restriction genes or near endogenous retroviral loci with one or more intact or almost-intact genes. We found that SNPs in the gene TRIM5 were inversely correlated with disease. Conversely, SNPs around one retroviral locus, HERV-Fc1, showed a highly significant association with disease. The latter association was limited to a narrow region that contains no other known genes. We conclude that HERV-Fc1 and TRIM5 play a role in the etiology of multiple sclerosis. If these results are confirmed, they point to new modes of treatment for multiple sclerosis.",

author = "Nex{\o}, {Bj{\o}rn Andersen} and Tove Christensen and Jette Frederiksen and Ann{\'e} M{\o}ller-Larsen and Oturai, {Annette Bang} and Palle Villesen and Bettina Hansen and Nissen, {Kari K} and Laska, {Magdalena J} and Petersen, {Trine Skov} and Sandra Bonnesen and Anne Hedemand and Tingting Wu and Xinjie Wang and Xiuqing Zhang and Tomasz Brudek and Romana Maric and Helle S{\o}ndergaard and Sellebjerg, {Finn Thorup} and Klaus Brusgaard and Kjeldbjerg, {Anders L} and Rasmussen, {Henrik B} and Nielsen, {Anders L} and Mette Nyegaard and Thor Petersen and B{\o}rglum, {Anders D} and Pedersen, {Finn S}",

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Nexø, BA, Christensen, T, Frederiksen, J, Møller-Larsen, A, Oturai, AB, Villesen, P, Hansen, B, Nissen, KK, Laska, MJ, Petersen, TS, Bonnesen, S, Hedemand, A, Wu, T, Wang, X, Zhang, X, Brudek, T, Maric, R, Søndergaard, H, Sellebjerg, FT, Brusgaard, K, Kjeldbjerg, AL, Rasmussen, HB, Nielsen, AL, Nyegaard, M, Petersen, T, Børglum, AD & Pedersen, FS 2011, 'The Etiology of Multiple Sclerosis: Genetic Evidence for the Involvement of the Human Endogenous Retrovirus HERV-Fc1', P L o S One, vol. 6, no. 2, pp. e16652. https://doi.org/10.1371/journal.pone.0016652

TY - JOUR

T1 - The Etiology of Multiple Sclerosis: Genetic Evidence for the Involvement of the Human Endogenous Retrovirus HERV-Fc1

AU - Nexø, Bjørn Andersen

AU - Christensen, Tove

AU - Frederiksen, Jette

AU - Møller-Larsen, Anné

AU - Oturai, Annette Bang

AU - Villesen, Palle

AU - Hansen, Bettina

AU - Nissen, Kari K

AU - Laska, Magdalena J

AU - Petersen, Trine Skov

AU - Bonnesen, Sandra

AU - Hedemand, Anne

AU - Wu, Tingting

AU - Wang, Xinjie

AU - Zhang, Xiuqing

AU - Brudek, Tomasz

AU - Maric, Romana

AU - Søndergaard, Helle

AU - Sellebjerg, Finn Thorup

AU - Brusgaard, Klaus

AU - Kjeldbjerg, Anders L

AU - Rasmussen, Henrik B

AU - Nielsen, Anders L

AU - Nyegaard, Mette

AU - Petersen, Thor

AU - Børglum, Anders D

AU - Pedersen, Finn S

PY - 2011/1/1

Y1 - 2011/1/1

N2 - We have investigated the role of human endogenous retroviruses in multiple sclerosis by analyzing the DNA of patients and controls in 4 cohorts for associations between multiple sclerosis and polymorphisms near viral restriction genes or near endogenous retroviral loci with one or more intact or almost-intact genes. We found that SNPs in the gene TRIM5 were inversely correlated with disease. Conversely, SNPs around one retroviral locus, HERV-Fc1, showed a highly significant association with disease. The latter association was limited to a narrow region that contains no other known genes. We conclude that HERV-Fc1 and TRIM5 play a role in the etiology of multiple sclerosis. If these results are confirmed, they point to new modes of treatment for multiple sclerosis.

AB - We have investigated the role of human endogenous retroviruses in multiple sclerosis by analyzing the DNA of patients and controls in 4 cohorts for associations between multiple sclerosis and polymorphisms near viral restriction genes or near endogenous retroviral loci with one or more intact or almost-intact genes. We found that SNPs in the gene TRIM5 were inversely correlated with disease. Conversely, SNPs around one retroviral locus, HERV-Fc1, showed a highly significant association with disease. The latter association was limited to a narrow region that contains no other known genes. We conclude that HERV-Fc1 and TRIM5 play a role in the etiology of multiple sclerosis. If these results are confirmed, they point to new modes of treatment for multiple sclerosis.

U2 - 10.1371/journal.pone.0016652

DO - 10.1371/journal.pone.0016652

M3 - Journal article

C2 - 21311761

SN - 1932-6203

VL - 6

SP - e16652

JO - P L o S One

JF - P L o S One

IS - 2

ER -

The Etiology of Multiple Sclerosis: Genetic Evidence for the Involvement of the Human Endogenous Retrovirus HERV-Fc1

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