The evolutionarily conserved miRNA-137 targets the neuropeptide hypocretin/orexin and modulates the wake to sleep ratio

Anja Holm*, Marie-Laure Possovre, Mojtaba Bandarabadi, Kristine F. Moseholm, Jessica L. Justinussen, Ivan Bozic, René Lemcke, Yoan Arribat, Francesca Amati, Asli Silahtaroglu, Maxime Juventin, Antoine Adamantidis, Mehdi Tafti, Birgitte R. Kornum

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Original languageEnglish
Article numbere2112225119
JournalProceedings of the National Academy of Sciences of the United States of America
Volume119
Issue number17
Pages (from-to)e2112225119
Number of pages10
ISSN0027-8424
DOIs
Publication statusPublished - 26 Apr 2022

Keywords

  • Animals
  • Intracellular Signaling Peptides and Proteins/genetics
  • Mice
  • MicroRNAs/genetics
  • Neuropeptides/metabolism
  • Orexins/genetics
  • Sleep/genetics
  • Wakefulness/genetics
  • Zebrafish/metabolism
  • sleep
  • miR-137
  • wake
  • hypocretin
  • orexin

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