Increasing evidence suggests an association between gene expression and clinical pain. Epigenetic modifications are the main modulators of gene expression or protein translation in response to environmental stimuli and pathophysiological conditions. Preclinical and clinical studies indicate that epigenetic modifications could also impact the development of pain, the transition from acute to chronic pain, and the maintenance hereof.
Bibliographical noteResearch funding: The Center for Neuroplasticity and Pain (CNAP) is supported by the Danish National Research Foundation (DNRF121). Center for Mathematical Modeling of Knee Osteoarthritis (MathKOA), Department of Material
and Production, Faculty of Engineering and Science, Aalborg University.
© 2022 Walter de Gruyter GmbH, Berlin/Boston.
- Chronic Pain/genetics
- Epigenesis, Genetic/genetics
- Pain Threshold
- epigenetic modifications
- epigenetic of pain