The link between epigenetics, pain sensitivity and chronic pain

Rocco Giordano; Kristian Kjær-Staal Petersen; Lars Arendt-Nielsen

doi:10.1515/sjpain-2022-0086

The link between epigenetics, pain sensitivity and chronic pain

Rocco Giordano, Kristian Kjær-Staal Petersen, Lars Arendt-Nielsen

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

22 Downloads (Pure)

Abstract

Increasing evidence suggests an association between gene expression and clinical pain. Epigenetic modifications are the main modulators of gene expression or protein translation in response to environmental stimuli and pathophysiological conditions. Preclinical and clinical studies indicate that epigenetic modifications could also impact the development of pain, the transition from acute to chronic pain, and the maintenance hereof.

Original language	English
Journal	Scandinavian Journal of Pain
Volume	22
Issue number	4
Pages (from-to)	664-666
Number of pages	3
ISSN	1877-8860
DOIs	https://doi.org/10.1515/sjpain-2022-0086
Publication status	Published - 26 Oct 2022

Bibliographical note

Research funding: The Center for Neuroplasticity and Pain (CNAP) is supported by the Danish National Research Foundation (DNRF121). Center for Mathematical Modeling of Knee Osteoarthritis (MathKOA), Department of Material
and Production, Faculty of Engineering and Science, Aalborg University.

© 2022 Walter de Gruyter GmbH, Berlin/Boston.

Keywords

Chronic Pain/genetics
Epigenesis, Genetic/genetics
Epigenomics
Humans
Pain Threshold
epigenetic modifications
microRNA
epigenetic of pain

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title = "The link between epigenetics, pain sensitivity and chronic pain",

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note = "Research funding: The Center for Neuroplasticity and Pain (CNAP) is supported by the Danish National Research Foundation (DNRF121). Center for Mathematical Modeling of Knee Osteoarthritis (MathKOA), Department of Material and Production, Faculty of Engineering and Science, Aalborg University. {\textcopyright} 2022 Walter de Gruyter GmbH, Berlin/Boston.",

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AU - Kjær-Staal Petersen, Kristian

AU - Arendt-Nielsen, Lars

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AB - Increasing evidence suggests an association between gene expression and clinical pain. Epigenetic modifications are the main modulators of gene expression or protein translation in response to environmental stimuli and pathophysiological conditions. Preclinical and clinical studies indicate that epigenetic modifications could also impact the development of pain, the transition from acute to chronic pain, and the maintenance hereof.

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KW - Epigenesis, Genetic/genetics

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JO - Scandinavian Journal of Pain

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IS - 4

ER -

The link between epigenetics, pain sensitivity and chronic pain

Abstract

Bibliographical note

Keywords

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