The macrophage activation marker sCD163 is associated with changes in NAFLD and metabolic profile during lifestyle intervention in obese children

K Kazankov; H J Møller; A Lange; N H Birkebaek; P Holland-Fischer; J Solvig; A Hørlyck; K Kristensen; S Rittig; A Handberg; H Vilstrup; H Grønbaek

doi:10.1111/ijpo.252

The macrophage activation marker sCD163 is associated with changes in NAFLD and metabolic profile during lifestyle intervention in obese children

K Kazankov, H J Møller, A Lange, N H Birkebaek, P Holland-Fischer, J Solvig, A Hørlyck, K Kristensen, S Rittig, A Handberg, H Vilstrup, H Grønbaek

Research output: Contribution to journal › Journal article › Research › peer-review

45 Citations (Scopus)

Abstract

BACKGROUND: Obesity is associated with metabolic derangement and non-alcoholic fatty liver disease (NAFLD). Macrophages are involved in liver inflammation and fibrosis, and soluble (s)CD163 is a macrophage activation marker.

OBJECTIVES: To associate sCD163 with parameters of paediatric obesity and NAFLD, as well as changes in these parameters during lifestyle intervention.

METHODS: We studied 117 obese children during a 10-week lifestyle intervention; 71 completed the 12-month follow-up. We recorded clinical and biochemical data, and performed liver ultrasonography.

RESULTS: Baseline sCD163 was higher in children with elevated alanine transaminase (ALT) (2.3 ± 0.7 vs. 2.0 ± 0.6 mg L(-1) , P = 0.03), steatosis (2.3 ± 0.7 vs. 2.0 ± 0.6 mg L(-1) , P = 0.01) and high paediatric NAFLD fibrosis index (2.3 ± 0.7 vs. 1.9 ± 0.6 mg L(-1) , P = 0.03). Baseline sCD163 was independently associated with ALT, cholesterol and high-sensitivity C-reactive protein (hs-CRP). The change in sCD163 during lifestyle intervention was associated with changes in ALT, homeostatic model assessment of insulin resistance (HOMA-IR), hs-CRP and cholesterol, and inversely associated with the change in high-density lipoprotein cholesterol.

CONCLUSION: sCD163 was associated with markers of liver injury and metabolic parameters in obese children, and changes in these parameters during lifestyle intervention. This may suggest that activated macrophages play a role in NAFLD and sCD163 may serve as a marker of liver disease severity and treatment effect.

Original language	English
Journal	Pediatric Obesity
Volume	10
Issue number	3
Pages (from-to)	226-233
Number of pages	8
ISSN	1747-7166
DOIs	https://doi.org/10.1111/ijpo.252
Publication status	Published - 2015

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Kazankov, K., Møller, H. J., Lange, A., Birkebaek, N. H., Holland-Fischer, P., Solvig, J., Hørlyck, A., Kristensen, K., Rittig, S., Handberg, A., Vilstrup, H., & Grønbaek, H. (2015). The macrophage activation marker sCD163 is associated with changes in NAFLD and metabolic profile during lifestyle intervention in obese children. Pediatric Obesity, 10(3), 226-233. https://doi.org/10.1111/ijpo.252

@article{eee0e5acef364346af5b7f2600f0d856,

title = "The macrophage activation marker sCD163 is associated with changes in NAFLD and metabolic profile during lifestyle intervention in obese children",

abstract = "BACKGROUND: Obesity is associated with metabolic derangement and non-alcoholic fatty liver disease (NAFLD). Macrophages are involved in liver inflammation and fibrosis, and soluble (s)CD163 is a macrophage activation marker.OBJECTIVES: To associate sCD163 with parameters of paediatric obesity and NAFLD, as well as changes in these parameters during lifestyle intervention.METHODS: We studied 117 obese children during a 10-week lifestyle intervention; 71 completed the 12-month follow-up. We recorded clinical and biochemical data, and performed liver ultrasonography.RESULTS: Baseline sCD163 was higher in children with elevated alanine transaminase (ALT) (2.3 ± 0.7 vs. 2.0 ± 0.6 mg L(-1) , P = 0.03), steatosis (2.3 ± 0.7 vs. 2.0 ± 0.6 mg L(-1) , P = 0.01) and high paediatric NAFLD fibrosis index (2.3 ± 0.7 vs. 1.9 ± 0.6 mg L(-1) , P = 0.03). Baseline sCD163 was independently associated with ALT, cholesterol and high-sensitivity C-reactive protein (hs-CRP). The change in sCD163 during lifestyle intervention was associated with changes in ALT, homeostatic model assessment of insulin resistance (HOMA-IR), hs-CRP and cholesterol, and inversely associated with the change in high-density lipoprotein cholesterol.CONCLUSION: sCD163 was associated with markers of liver injury and metabolic parameters in obese children, and changes in these parameters during lifestyle intervention. This may suggest that activated macrophages play a role in NAFLD and sCD163 may serve as a marker of liver disease severity and treatment effect.",

author = "K Kazankov and M{\o}ller, {H J} and A Lange and Birkebaek, {N H} and P Holland-Fischer and J Solvig and A H{\o}rlyck and K Kristensen and S Rittig and A Handberg and H Vilstrup and H Gr{\o}nbaek",

note = "{\textcopyright} 2014 The Authors. Pediatric Obesity {\textcopyright} 2014 World Obesity.",

year = "2015",

doi = "10.1111/ijpo.252",

language = "English",

volume = "10",

pages = "226--233",

journal = "Pediatric Obesity",

issn = "1747-7166",

publisher = "Wiley-Blackwell",

number = "3",

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Kazankov, K, Møller, HJ, Lange, A, Birkebaek, NH, Holland-Fischer, P, Solvig, J, Hørlyck, A, Kristensen, K, Rittig, S, Handberg, A, Vilstrup, H & Grønbaek, H 2015, 'The macrophage activation marker sCD163 is associated with changes in NAFLD and metabolic profile during lifestyle intervention in obese children', Pediatric Obesity, vol. 10, no. 3, pp. 226-233. https://doi.org/10.1111/ijpo.252

TY - JOUR

T1 - The macrophage activation marker sCD163 is associated with changes in NAFLD and metabolic profile during lifestyle intervention in obese children

AU - Kazankov, K

AU - Møller, H J

AU - Lange, A

AU - Birkebaek, N H

AU - Holland-Fischer, P

AU - Solvig, J

AU - Hørlyck, A

AU - Kristensen, K

AU - Rittig, S

AU - Handberg, A

AU - Vilstrup, H

AU - Grønbaek, H

PY - 2015

Y1 - 2015

N2 - BACKGROUND: Obesity is associated with metabolic derangement and non-alcoholic fatty liver disease (NAFLD). Macrophages are involved in liver inflammation and fibrosis, and soluble (s)CD163 is a macrophage activation marker.OBJECTIVES: To associate sCD163 with parameters of paediatric obesity and NAFLD, as well as changes in these parameters during lifestyle intervention.METHODS: We studied 117 obese children during a 10-week lifestyle intervention; 71 completed the 12-month follow-up. We recorded clinical and biochemical data, and performed liver ultrasonography.RESULTS: Baseline sCD163 was higher in children with elevated alanine transaminase (ALT) (2.3 ± 0.7 vs. 2.0 ± 0.6 mg L(-1) , P = 0.03), steatosis (2.3 ± 0.7 vs. 2.0 ± 0.6 mg L(-1) , P = 0.01) and high paediatric NAFLD fibrosis index (2.3 ± 0.7 vs. 1.9 ± 0.6 mg L(-1) , P = 0.03). Baseline sCD163 was independently associated with ALT, cholesterol and high-sensitivity C-reactive protein (hs-CRP). The change in sCD163 during lifestyle intervention was associated with changes in ALT, homeostatic model assessment of insulin resistance (HOMA-IR), hs-CRP and cholesterol, and inversely associated with the change in high-density lipoprotein cholesterol.CONCLUSION: sCD163 was associated with markers of liver injury and metabolic parameters in obese children, and changes in these parameters during lifestyle intervention. This may suggest that activated macrophages play a role in NAFLD and sCD163 may serve as a marker of liver disease severity and treatment effect.

AB - BACKGROUND: Obesity is associated with metabolic derangement and non-alcoholic fatty liver disease (NAFLD). Macrophages are involved in liver inflammation and fibrosis, and soluble (s)CD163 is a macrophage activation marker.OBJECTIVES: To associate sCD163 with parameters of paediatric obesity and NAFLD, as well as changes in these parameters during lifestyle intervention.METHODS: We studied 117 obese children during a 10-week lifestyle intervention; 71 completed the 12-month follow-up. We recorded clinical and biochemical data, and performed liver ultrasonography.RESULTS: Baseline sCD163 was higher in children with elevated alanine transaminase (ALT) (2.3 ± 0.7 vs. 2.0 ± 0.6 mg L(-1) , P = 0.03), steatosis (2.3 ± 0.7 vs. 2.0 ± 0.6 mg L(-1) , P = 0.01) and high paediatric NAFLD fibrosis index (2.3 ± 0.7 vs. 1.9 ± 0.6 mg L(-1) , P = 0.03). Baseline sCD163 was independently associated with ALT, cholesterol and high-sensitivity C-reactive protein (hs-CRP). The change in sCD163 during lifestyle intervention was associated with changes in ALT, homeostatic model assessment of insulin resistance (HOMA-IR), hs-CRP and cholesterol, and inversely associated with the change in high-density lipoprotein cholesterol.CONCLUSION: sCD163 was associated with markers of liver injury and metabolic parameters in obese children, and changes in these parameters during lifestyle intervention. This may suggest that activated macrophages play a role in NAFLD and sCD163 may serve as a marker of liver disease severity and treatment effect.

U2 - 10.1111/ijpo.252

DO - 10.1111/ijpo.252

M3 - Journal article

C2 - 25073966

SN - 1747-7166

VL - 10

SP - 226

EP - 233

JO - Pediatric Obesity

JF - Pediatric Obesity

IS - 3

ER -

The macrophage activation marker sCD163 is associated with changes in NAFLD and metabolic profile during lifestyle intervention in obese children

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