The Many Faces of Diphenylalanine

Mohtadin Hashemi, Peter Fojan, Leonid Gurevich

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Diphenylalanine is well known to form complex self-assembled structures, including peptide nanowires, with morphologies depending on N- and C-terminal modifications. Here we report that significant morphological variations of self-assembled structures are attainable through pH variation of unmodified diphenylalanine in trifluoroethanol. The obtained self-assembled diphenylalanine nanostructures are found to vary drastically with pH, incubation time, and diphenylalanine concentration in solution. The observed structures ranged from structured films at neutral and alkaline conditions to vertically aligned nanowires and sponge-like structures at acidic conditions. These observations are corroborated by the results of electrostatic modelling, indicating the disappearance of the dipole moment at high pH values. This also emphasizes the importance of the dipole moment for the resulting self-assembled structures. Our results suggest that, in comparison to the commonly described procedure of diphenylaniline nanowire growth through aniline vapor treatment, strictly anhydrous conditions are not necessarily required.
    Original languageEnglish
    JournalJournal of Self-Assembly and Molecular Electronics (SAME)
    Volume1
    Issue number2
    Pages (from-to)195-208
    ISSN2245-4551
    DOIs
    Publication statusPublished - 2013

    Keywords

    • Diphenylalanine
    • peptide self-assembly
    • peptide nanowires
    • peptide nanotubes

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