Research output per year
Research output per year
Marijana Nesic, Mads Sønderkær, Rasmus Froberg Brøndum, Tarec Christoffer El-Galaly, Inge Søkilde Pedersen, Martin Bøgsted, Karen Dybkær*
Research output: Contribution to journal › Journal article › Research › peer-review
BACKGROUND: Diffuse large B-cell lymphoma (DLBCL) is the most frequent lymphoid neoplasm among adults,and approximately 30-40% of patients will experience relapse while 5-10% will suffer from primary refractory disease caused by different mechanisms, including treatment-induced resistance. For refractory and relapsed DLBCL (rrDLBCL) patients, early detection and understanding of the mechanisms controlling treatment resistance are of great importance to guide therapy decisions. Here, we have focused on genetic variations in immune surveillance genes in diagnostic DLBCL (dDLBCL) and rrDLBCL patients to elaborate on the suitability of new promising immunotherapies.
METHODS: Biopsies from 30 dDLBCL patients who did not progress or relapse during follow up and 17 rrDLBCL patients with refractory disease or who relapsed during follow up were analyzed by whole-exome sequencing, including matched individual germline samples to include only somatic genetic variants in downstream analysis of a curated list of 58 genes involved in major immune surveillance pathways.
RESULTS: More than 70% of both dDLBCLs and rrDLBCLs harbored alterations in immune surveillance genes, but rrDLBCL tumor samples have a lower number of genes affected compared to dDLBCL tumor samples. Increased gene mutation frequencies in rrDLBCLs were observed in more than half of the affected immune surveillance genes than dDLBCLs.
CONCLUSION: Genetic variants in the antigen-presenting genes affect a higher number of rrDLBCL patients supporting an important role for these genes in tumor progression and development of refractory disease and relapse.
Original language | English |
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Article number | 829 |
Journal | BMC Cancer |
Volume | 21 |
Issue number | 1 |
Number of pages | 12 |
ISSN | 1471-2407 |
DOIs | |
Publication status | Published - 18 Jul 2021 |
Research output: PhD thesis
Nesic, M. (Creator), Sønderkær, M. (Creator), Brøndum, R. F. (Creator), El-Galaly, T. C. (Creator), Pedersen, I. S. (Creator), Bøgsted, M. (Creator) & Dybkær, K. (Creator), Figshare, 2021
DOI: 10.6084/m9.figshare.c.5517603.v1, https://springernature.figshare.com/collections/The_mutational_profile_of_immune_surveillance_genes_in_diagnostic_and_refractory_relapsed_DLBCLs/5517603/1
Dataset
Nesic, M. (Creator), Sønderkær, M. (Creator), Brøndum, R. F. (Creator), El-Galaly, T. C. (Creator), Pedersen, I. S. (Creator), Bøgsted, M. (Creator) & Dybkær, K. (Creator), Figshare, 2021
DOI: 10.6084/m9.figshare.c.5517603, https://springernature.figshare.com/collections/The_mutational_profile_of_immune_surveillance_genes_in_diagnostic_and_refractory_relapsed_DLBCLs/5517603
Dataset
Bøgsted, M. (Creator), Nesic, M. (Creator), Sønderkær, M. (Creator), Dybkær, K. (Creator), Brøndum, R. F. (Creator), El-Galaly, T. C. (Creator) & Pedersen, I. S. (Creator), Figshare, 2021
DOI: 10.6084/m9.figshare.15001314.v1, https://doi.org/10.6084%2Fm9.figshare.15001314.v1
Dataset