The neurophysiology of the esophagus

Philip Woodland, Daniel Sifrim, Anne Lund Krarup, Christina Brock, Jens Brøndum Frøkjaer, Christian Lottrup, Asbjørn Mohr Drewes, Lee L Swanstrom, Adam D Farmer

Research output: Contribution to journalConference article in JournalResearchpeer-review

15 Citations (Scopus)

Abstract

This paper reports on the neurophysiology of the esophagus, including on the uneven distribution of innervation in the esophagus, reflected by the increased sensitivity and perception of gastroesophageal reflux disease (GERD) events in the proximal rather than distal esophagus; the role of the enteric nervous system (ENS) in swallowing; the role of the physiological stress-responsive systems, including the autonomic nervous system (ANS) and the hypothalamic-pituitary-adrenal (HPA) axis in mediating esophageal pain; the advances in understanding pain mechanisms and brain structure provided by technological imaging advances; investigations into the efficacy of the descending-pain control system, including diffuse noxious inhibitory control (DNIC); the role of abnormal nervous signaling in afferent pathways in the pathogenesis of Barrett's esophagus (BE); and the contribution of the esophageal mucosa to reflux symptoms.
Original languageEnglish
JournalAnnals of the New York Academy of Sciences
Volume1300
Issue number1
Pages (from-to)53-70
Number of pages18
ISSN0077-8923
DOIs
Publication statusPublished - Oct 2013
EventWorld Congress of the World Organization for Specialized Studies on Diseases of the Esophagus - Como, Italy
Duration: 1 Sept 20124 Sept 2012
Conference number: 11

Conference

ConferenceWorld Congress of the World Organization for Specialized Studies on Diseases of the Esophagus
Number11
Country/TerritoryItaly
CityComo
Period01/09/201204/09/2012

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