The potential role of sensory testing, skin biopsy, and functional brain imaging as biomarkers in chronic pain clinical trials: IMMPACT considerations

Shannon M. Smith, Robert H. Dworkin, Dennis C. Turk, Ralf Baron, Michael Polydefkis, Irene Tracey, David Borsook, Robert Edwards, Richard E. Harris, Tor D. Wager, Lars Arendt-Nielsen, Laurie B. Burke, Daniel B. Carr, Amy S. Chappell, John T. Farrar, Roy Freeman, Ian Gilron, Veeraindar Goli, Juergen Haeussler, Troels Jensen & 16 others Nathaniel P. Katz, Jeffrey Kent, Ernest A. Kopecky, David A. Lee, William Maixner, John D. Markman, Justin C. McArthur, Michael P. McDermott, Lav Parvathenani, Srinivasa N. Raja, Bob A. Rappaport, Andrew S C Rice, Michael C. Rowbotham, Jeffrey K. Tobias, Ajay D. Wasan, James Witter

Research output: Contribution to journalReview articleResearchpeer-review

18 Citations (Scopus)
Original languageEnglish
JournalJournal of Pain
Volume18
Issue number7
Pages (from-to)757-777
ISSN1526-5900
DOIs
Publication statusPublished - 2017

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Functional Neuroimaging
Chronic Pain
Biomarkers
Clinical Trials
Biopsy
Skin
Neuroimaging
Pain
Analgesics
Pain Measurement
United States Food and Drug Administration
Reproducibility of Results
Therapeutics

Keywords

  • Biomarkers
  • Brain imaging
  • IMMPACT
  • Sensory testing
  • Skin punch biopsy

Cite this

Smith, Shannon M. ; Dworkin, Robert H. ; Turk, Dennis C. ; Baron, Ralf ; Polydefkis, Michael ; Tracey, Irene ; Borsook, David ; Edwards, Robert ; Harris, Richard E. ; Wager, Tor D. ; Arendt-Nielsen, Lars ; Burke, Laurie B. ; Carr, Daniel B. ; Chappell, Amy S. ; Farrar, John T. ; Freeman, Roy ; Gilron, Ian ; Goli, Veeraindar ; Haeussler, Juergen ; Jensen, Troels ; Katz, Nathaniel P. ; Kent, Jeffrey ; Kopecky, Ernest A. ; Lee, David A. ; Maixner, William ; Markman, John D. ; McArthur, Justin C. ; McDermott, Michael P. ; Parvathenani, Lav ; Raja, Srinivasa N. ; Rappaport, Bob A. ; Rice, Andrew S C ; Rowbotham, Michael C. ; Tobias, Jeffrey K. ; Wasan, Ajay D. ; Witter, James. / The potential role of sensory testing, skin biopsy, and functional brain imaging as biomarkers in chronic pain clinical trials : IMMPACT considerations. In: Journal of Pain. 2017 ; Vol. 18, No. 7. pp. 757-777.
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title = "The potential role of sensory testing, skin biopsy, and functional brain imaging as biomarkers in chronic pain clinical trials: IMMPACT considerations",
keywords = "Biomarkers, Brain imaging, IMMPACT, Sensory testing, Skin punch biopsy",
author = "Smith, {Shannon M.} and Dworkin, {Robert H.} and Turk, {Dennis C.} and Ralf Baron and Michael Polydefkis and Irene Tracey and David Borsook and Robert Edwards and Harris, {Richard E.} and Wager, {Tor D.} and Lars Arendt-Nielsen and Burke, {Laurie B.} and Carr, {Daniel B.} and Chappell, {Amy S.} and Farrar, {John T.} and Roy Freeman and Ian Gilron and Veeraindar Goli and Juergen Haeussler and Troels Jensen and Katz, {Nathaniel P.} and Jeffrey Kent and Kopecky, {Ernest A.} and Lee, {David A.} and William Maixner and Markman, {John D.} and McArthur, {Justin C.} and McDermott, {Michael P.} and Lav Parvathenani and Raja, {Srinivasa N.} and Rappaport, {Bob A.} and Rice, {Andrew S C} and Rowbotham, {Michael C.} and Tobias, {Jeffrey K.} and Wasan, {Ajay D.} and James Witter",
year = "2017",
doi = "10.1016/j.jpain.2017.02.429",
language = "English",
volume = "18",
pages = "757--777",
journal = "Journal of Pain",
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Smith, SM, Dworkin, RH, Turk, DC, Baron, R, Polydefkis, M, Tracey, I, Borsook, D, Edwards, R, Harris, RE, Wager, TD, Arendt-Nielsen, L, Burke, LB, Carr, DB, Chappell, AS, Farrar, JT, Freeman, R, Gilron, I, Goli, V, Haeussler, J, Jensen, T, Katz, NP, Kent, J, Kopecky, EA, Lee, DA, Maixner, W, Markman, JD, McArthur, JC, McDermott, MP, Parvathenani, L, Raja, SN, Rappaport, BA, Rice, ASC, Rowbotham, MC, Tobias, JK, Wasan, AD & Witter, J 2017, 'The potential role of sensory testing, skin biopsy, and functional brain imaging as biomarkers in chronic pain clinical trials: IMMPACT considerations' Journal of Pain, vol. 18, no. 7, pp. 757-777. https://doi.org/10.1016/j.jpain.2017.02.429

The potential role of sensory testing, skin biopsy, and functional brain imaging as biomarkers in chronic pain clinical trials : IMMPACT considerations. / Smith, Shannon M.; Dworkin, Robert H.; Turk, Dennis C.; Baron, Ralf; Polydefkis, Michael; Tracey, Irene; Borsook, David; Edwards, Robert; Harris, Richard E.; Wager, Tor D.; Arendt-Nielsen, Lars; Burke, Laurie B.; Carr, Daniel B.; Chappell, Amy S.; Farrar, John T.; Freeman, Roy; Gilron, Ian; Goli, Veeraindar; Haeussler, Juergen; Jensen, Troels; Katz, Nathaniel P.; Kent, Jeffrey; Kopecky, Ernest A.; Lee, David A.; Maixner, William; Markman, John D.; McArthur, Justin C.; McDermott, Michael P.; Parvathenani, Lav; Raja, Srinivasa N.; Rappaport, Bob A.; Rice, Andrew S C; Rowbotham, Michael C.; Tobias, Jeffrey K.; Wasan, Ajay D.; Witter, James.

In: Journal of Pain, Vol. 18, No. 7, 2017, p. 757-777.

Research output: Contribution to journalReview articleResearchpeer-review

TY - JOUR

T1 - The potential role of sensory testing, skin biopsy, and functional brain imaging as biomarkers in chronic pain clinical trials

T2 - IMMPACT considerations

AU - Smith, Shannon M.

AU - Dworkin, Robert H.

AU - Turk, Dennis C.

AU - Baron, Ralf

AU - Polydefkis, Michael

AU - Tracey, Irene

AU - Borsook, David

AU - Edwards, Robert

AU - Harris, Richard E.

AU - Wager, Tor D.

AU - Arendt-Nielsen, Lars

AU - Burke, Laurie B.

AU - Carr, Daniel B.

AU - Chappell, Amy S.

AU - Farrar, John T.

AU - Freeman, Roy

AU - Gilron, Ian

AU - Goli, Veeraindar

AU - Haeussler, Juergen

AU - Jensen, Troels

AU - Katz, Nathaniel P.

AU - Kent, Jeffrey

AU - Kopecky, Ernest A.

AU - Lee, David A.

AU - Maixner, William

AU - Markman, John D.

AU - McArthur, Justin C.

AU - McDermott, Michael P.

AU - Parvathenani, Lav

AU - Raja, Srinivasa N.

AU - Rappaport, Bob A.

AU - Rice, Andrew S C

AU - Rowbotham, Michael C.

AU - Tobias, Jeffrey K.

AU - Wasan, Ajay D.

AU - Witter, James

PY - 2017

Y1 - 2017

KW - Biomarkers

KW - Brain imaging

KW - IMMPACT

KW - Sensory testing

KW - Skin punch biopsy

U2 - 10.1016/j.jpain.2017.02.429

DO - 10.1016/j.jpain.2017.02.429

M3 - Review article

VL - 18

SP - 757

EP - 777

JO - Journal of Pain

JF - Journal of Pain

SN - 1526-5900

IS - 7

ER -