TY - JOUR
T1 - The use of venous blood gas in assessing arterial acid-base and oxygenation status - an analysis of aggregated data from multiple studies evaluating the venous to arterial conversion (v-TAC) method
AU - Shastri, Lisha
AU - Thomsen, Lars Pilegaard
AU - Toftegaard, Marianne
AU - Tygesen, Gitte Boier
AU - Weinreich, Ulla Møller
AU - Rychwicka-Kielek, Beate Agnieszka
AU - Davies, Michael Gordon
AU - Ekström, Magnus
AU - Rittger, Harald
AU - Kelly, Anne-Maree
AU - Kristensen, Søren Risom
AU - Kjærgaard, Søren
AU - Kamperidis, Panagiotis
AU - Manuel, Ari
AU - Damgaard, Kjeld Asbjørn
AU - Andreassen, Steen
AU - Rees, Stephen Edward
PY - 2024
Y1 - 2024
N2 - BACKGROUND: Several methods exist to reduce the number of arterial blood gases (ABGs). One method, Roche v-TAC, has been evaluated in different patient groups. This paper aggregates data from these studies, in different patient categories using common analysis criteria.RESEARCH DESIGN AND METHODS: We included studies evaluating v-TAC based on paired arterial and peripheral venous blood samples. Bland-Altman analysis compared measured and calculated arterial values of pH, PCO2, and PO2. Subgroup analyses were performed for normal, chronic hypercapnia and chronic base excess, acute hyper- and hypocapnia, and acute and chronic base deficits.RESULTS: 811 samples from 12 studies were included. Bias and limits of agreement for measured and calculated values: pH 0.001 (-0.029 to 0.031), PCO2 -0.08 (-0.65 to 0.49) kPa, and PO2 0.04 (-1.71 to 1.78) kPa, with similar values for all sub-group analyses.CONCLUSION: These data suggest that v-TAC analysis may have a role in replacing ABGs, avoiding arterial puncture. Substantial data exist in patients with chronic hypercapnia and chronic base excess, acute hyper- and hypocapnia, and in patients with relatively normal acid-base status, with similar bias and precision across groups and across study data. Limited data exist for patients with acute and chronic base deficits.
AB - BACKGROUND: Several methods exist to reduce the number of arterial blood gases (ABGs). One method, Roche v-TAC, has been evaluated in different patient groups. This paper aggregates data from these studies, in different patient categories using common analysis criteria.RESEARCH DESIGN AND METHODS: We included studies evaluating v-TAC based on paired arterial and peripheral venous blood samples. Bland-Altman analysis compared measured and calculated arterial values of pH, PCO2, and PO2. Subgroup analyses were performed for normal, chronic hypercapnia and chronic base excess, acute hyper- and hypocapnia, and acute and chronic base deficits.RESULTS: 811 samples from 12 studies were included. Bias and limits of agreement for measured and calculated values: pH 0.001 (-0.029 to 0.031), PCO2 -0.08 (-0.65 to 0.49) kPa, and PO2 0.04 (-1.71 to 1.78) kPa, with similar values for all sub-group analyses.CONCLUSION: These data suggest that v-TAC analysis may have a role in replacing ABGs, avoiding arterial puncture. Substantial data exist in patients with chronic hypercapnia and chronic base excess, acute hyper- and hypocapnia, and in patients with relatively normal acid-base status, with similar bias and precision across groups and across study data. Limited data exist for patients with acute and chronic base deficits.
KW - Pulmonary medicine
KW - emergency medicine
KW - non-invasive ventilation
KW - peripheral venous blood
KW - respiratory and acid−base status
UR - http://www.scopus.com/inward/record.url?scp=85198501788&partnerID=8YFLogxK
U2 - 10.1080/17476348.2024.2378021
DO - 10.1080/17476348.2024.2378021
M3 - Journal article
C2 - 38973767
SN - 1747-6348
VL - 18
SP - 553
EP - 559
JO - Expert review of respiratory medicine
JF - Expert review of respiratory medicine
IS - 7
ER -