OBJECTIVE: The current standard imaging recommended for primary staging of intermediate- and high-risk prostate cancer (PCa) consists of bone scintigraphy (BS) and computed tomography (CT). Some patients will have equivocal lesions or divergent findings on BS and CT, leading to inconclusive disease staging. Our aim was to investigate the value of 68Ga-PSMA-11 PET/CT in PCa with inconclusive disease stage based on standard imaging.
METHODS: We made a single-center study of patients with newly diagnosed PCa who underwent a 68Ga-PSMA-11 PET/CT due to equivocal findings or discrepancies between BS and CT from 1 January 2017 to 31 December 2020. The value of 68Ga-PSMA-11 PET/CT was evaluated for each location of equivocal findings (regional lymphnode, nonregional lymphnodes, bones and other metastases) and on a patient level.
RESULTS: Seventy-six patients were included in the study (62 patients with 72 equivocal lesions, 14 with discrepancy between BS and CT). Equivocal lesions were predominately in the bones (61%, 44/72), or in the regional lymph nodes (17%, 12/72). 68Ga-PSMA-11 PET/CT provided a conclusive diagnosis in 90% (65/72) of the equivocal lesions. All patients with discrepancies between BS and CT had definite answers after 68Ga-PSMA-11 PET/CT. 68Ga-PSMA-11 PET/CT also uncovered 32 additional sites of metastasis in 25 patients not visible by standard imaging.
CONCLUSION: 68Ga-PSMA-11 PET/CT provides a definite disease stage in more than 90% of newly diagnosed patients with inconclusive standard imaging. Furthermore, it revealed additional sites of metastasis in 25 patients not detected by standard imaging.
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- Gallium Radioisotopes
- Neoplasm Staging
- Positron Emission Tomography Computed Tomography/methods
- Prostatic Neoplasms/diagnostic imaging
- Tomography, X-Ray Computed
- prostate cancer
- standard imaging
- Ga-PSMA-11 PET/CT
- equivocal findings
- primary staging