Toxic iron species in lower-risk myelodysplastic syndrome patients: course of disease and effects on outcome

Marlijn Hoeks; Tim Bagguley; Corine van Marrewijk; Alex Smith; David Bowen; Dominic Culligan; Seye Kolade; Argiris Symeonidis; Hege Garelius; Michail Spanoudakis; Saskia Langemeijer; Rian Roelofs; Erwin Wiegerinck; Aurelia Tatic; Sally Killick; Panagiotis Panagiotidis; Oana Stanca; Eva Hellström-Lindberg; Jaroslav Cermak; Melanie van der Klauw; Hanneke Wouters; Marian van Kraaij; Nicole Blijlevens; Dorine W. Swinkels; Theo de Witte; R. Stauder; A. Walder; M. Pfeilstöcker; A. Schoenmetzler-Makrai; S. Burgstaller; J. Thaler; I. Mandac Rogulj; M. Krejci; J. Voglova; P. Rohon; A. Jonasova; J. Cermak; D. Mikulenkova; I. Hochova; P. D. Jensen; M. S. Holm; L. Kjeldsen; I. H. Dufva; H. Vestergaard; D. Re; B. Slama; P. Fenaux; B. Choufi; S. Cheze; D. Klepping; B. Salles; B. de Renzis; L. Willems; D. De Prost; J. Gutnecht; S. Courby; V. Siguret; G. Tertian; L. Pascal; M. Chaury; E. Wattel; A. Guerci; L. Legros; R. Itzykson; L. Ades; F. Isnard; L. Sanhes; R. Benramdane; A. Stamatoullas; S. Amé; O. Beyne-Rauzy; E. Gyan; U. Platzbecker; C. Badrakan; U. Germing; M. Lübbert; R. Schlenk; I. Kotsianidis; C. Tsatalas; V. Pappa; A. Galanopoulos; E. Michali; P. Panagiotidis; N. Viniou; A. Katsigiannis; P. Roussou; E. Terpos; A. Kostourou; Z. Kartasis; A. Pouli; K. Palla; V. Briasoulis; E. Hatzimichael; G. Vassilopoulos; A. Symeonidis; A. Kourakli; P. Zikos; A. Anagnostopoulos; M. Kotsopoulou; K. Megalakaki; M. Protopapa; E. Vlachaki; P. Konstantinidou; G. Stemer; A. Nemetz; U. Gotwin; O. Cohen; M. Koren; E. Levy; U. Greenbaum; S. Gino-Moor; M. Price; Y. Ofran; A. Winder; N. Goldshmidt; S. Elias; R. Sabag; I. Hellman; M. Ellis; A. Braester; H. Rosenbaum; S. Berdichevsky; G. Itzhaki; O. Wolaj; S. Yeganeh; O. Katz; K. Filanovsky; N. Dali; M. Mittelman; L. Malcovati; L. Fianchi; A. vd Loosdrecht; V. Matthijssen; A. Herbers; H. Pruijt; N. Aboosy; F. de Vries; G. Velders; E. Jacobs; S. Langemeijer; M. MacKenzie; C. Lensen; P. Kuijper; K. Madry; M. Camara; A. Almeida; G. Vulkan; O. Stanca Ciocan; A. Tatic; A. Savic; C. Pedro; B. Xicoy; P. Leiva; J. Munoz; V. Betes; C. Benavente; M. Lozano; M. Martinez; P. Iniesta; T. Bernal; M. Diez Campelo; D. Tormo; R. Andreu Lapiedra; G. Sanz; E. Hesse Sundin; H. Garelius; C. Karlsson; P. Antunovic; A. Jönsson; L. Brandefors; L. Nilsson; P. Kozlowski; E. Hellstrom-Lindberg; M. Grövdal; K. Larsson; J. Wallvik; F. Lorenz; E. Ejerblad; D. Culligan; C. Craddock; S. Kolade; P. Cahalin; S. Killick; S. Ackroyd; C. Wong; A. Warren; M. Drummond; C. Hall; K. Rothwell; S. Green; S. Ali; M. Karakantza; M. Dennis; G. Jones; J. Parker; A. Bowen; R. Radia; E. Das-Gupta; P. Vyas; E. Nga; D. Creagh; J. Ashcroft; J. Mills; L. Bond; the EUMDS Registry Participants

doi:10.1038/s41375-020-01022-2

Toxic iron species in lower-risk myelodysplastic syndrome patients: course of disease and effects on outcome

Marlijn Hoeks^*, Tim Bagguley, Corine van Marrewijk, Alex Smith, David Bowen, Dominic Culligan, Seye Kolade, Argiris Symeonidis, Hege Garelius, Michail Spanoudakis, Saskia Langemeijer, Rian Roelofs, Erwin Wiegerinck, Aurelia Tatic, Sally Killick, Panagiotis Panagiotidis, Oana Stanca, Eva Hellström-Lindberg, Jaroslav Cermak, Melanie van der KlauwHanneke Wouters, Marian van Kraaij, Nicole Blijlevens, Dorine W. Swinkels, Theo de Witte, R. Stauder, A. Walder, M. Pfeilstöcker, A. Schoenmetzler-Makrai, S. Burgstaller, J. Thaler, I. Mandac Rogulj, M. Krejci, J. Voglova, P. Rohon, A. Jonasova, J. Cermak, D. Mikulenkova, I. Hochova, P. D. Jensen, M. S. Holm, L. Kjeldsen, I. H. Dufva, H. Vestergaard, D. Re, B. Slama, P. Fenaux, B. Choufi, S. Cheze, D. Klepping, B. Salles, B. de Renzis, L. Willems, D. De Prost, J. Gutnecht, S. Courby, V. Siguret, G. Tertian, L. Pascal, M. Chaury, E. Wattel, A. Guerci, L. Legros, R. Itzykson, L. Ades, F. Isnard, L. Sanhes, R. Benramdane, A. Stamatoullas, S. Amé, O. Beyne-Rauzy, E. Gyan, U. Platzbecker, C. Badrakan, U. Germing, M. Lübbert, R. Schlenk, I. Kotsianidis, C. Tsatalas, V. Pappa, A. Galanopoulos, E. Michali, P. Panagiotidis, N. Viniou, A. Katsigiannis, P. Roussou, E. Terpos, A. Kostourou, Z. Kartasis, A. Pouli, K. Palla, V. Briasoulis, E. Hatzimichael, G. Vassilopoulos, A. Symeonidis, A. Kourakli, P. Zikos, A. Anagnostopoulos, M. Kotsopoulou, K. Megalakaki, M. Protopapa, E. Vlachaki, P. Konstantinidou, G. Stemer, A. Nemetz, U. Gotwin, O. Cohen, M. Koren, E. Levy, U. Greenbaum, S. Gino-Moor, M. Price, Y. Ofran, A. Winder, N. Goldshmidt, S. Elias, R. Sabag, I. Hellman, M. Ellis, A. Braester, H. Rosenbaum, S. Berdichevsky, G. Itzhaki, O. Wolaj, S. Yeganeh, O. Katz, K. Filanovsky, N. Dali, M. Mittelman, L. Malcovati, L. Fianchi, A. vd Loosdrecht, V. Matthijssen, A. Herbers, H. Pruijt, N. Aboosy, F. de Vries, G. Velders, E. Jacobs, S. Langemeijer, M. MacKenzie, C. Lensen, P. Kuijper, K. Madry, M. Camara, A. Almeida, G. Vulkan, O. Stanca Ciocan, A. Tatic, A. Savic, C. Pedro, B. Xicoy, P. Leiva, J. Munoz, V. Betes, C. Benavente, M. Lozano, M. Martinez, P. Iniesta, T. Bernal, M. Diez Campelo, D. Tormo, R. Andreu Lapiedra, G. Sanz, E. Hesse Sundin, H. Garelius, C. Karlsson, P. Antunovic, A. Jönsson, L. Brandefors, L. Nilsson, P. Kozlowski, E. Hellstrom-Lindberg, M. Grövdal, K. Larsson, J. Wallvik, F. Lorenz, E. Ejerblad, D. Culligan, C. Craddock, S. Kolade, P. Cahalin, S. Killick, S. Ackroyd, C. Wong, A. Warren, M. Drummond, C. Hall, K. Rothwell, S. Green, S. Ali, M. Karakantza, M. Dennis, G. Jones, J. Parker, A. Bowen, R. Radia, E. Das-Gupta, P. Vyas, E. Nga, D. Creagh, J. Ashcroft, J. Mills, L. Bond, the EUMDS Registry Participants

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

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Original language	English
Journal	Leukemia
Volume	35
Issue number	6
Pages (from-to)	1745-1750
Number of pages	6
ISSN	0887-6924
DOIs	https://doi.org/10.1038/s41375-020-01022-2
Publication status	Published - Jun 2021

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Hoeks, M., Bagguley, T., van Marrewijk, C., Smith, A., Bowen, D., Culligan, D., Kolade, S., Symeonidis, A., Garelius, H., Spanoudakis, M., Langemeijer, S., Roelofs, R., Wiegerinck, E., Tatic, A., Killick, S., Panagiotidis, P., Stanca, O., Hellström-Lindberg, E., Cermak, J., ... the EUMDS Registry Participants (2021). Toxic iron species in lower-risk myelodysplastic syndrome patients: course of disease and effects on outcome. Leukemia, 35(6), 1745-1750. https://doi.org/10.1038/s41375-020-01022-2

@article{ca4cd35f05fc4989964029a52f7893f7,

title = "Toxic iron species in lower-risk myelodysplastic syndrome patients: course of disease and effects on outcome",

author = "Marlijn Hoeks and Tim Bagguley and {van Marrewijk}, Corine and Alex Smith and David Bowen and Dominic Culligan and Seye Kolade and Argiris Symeonidis and Hege Garelius and Michail Spanoudakis and Saskia Langemeijer and Rian Roelofs and Erwin Wiegerinck and Aurelia Tatic and Sally Killick and Panagiotis Panagiotidis and Oana Stanca and Eva Hellstr{\"o}m-Lindberg and Jaroslav Cermak and {van der Klauw}, Melanie and Hanneke Wouters and {van Kraaij}, Marian and Nicole Blijlevens and Swinkels, {Dorine W.} and {de Witte}, Theo and R. Stauder and A. Walder and M. Pfeilst{\"o}cker and A. Schoenmetzler-Makrai and S. Burgstaller and J. Thaler and {Mandac Rogulj}, I. and M. Krejci and J. Voglova and P. Rohon and A. Jonasova and J. Cermak and D. Mikulenkova and I. Hochova and Jensen, {P. D.} and Holm, {M. S.} and L. Kjeldsen and Dufva, {I. H.} and H. Vestergaard and D. Re and B. Slama and P. Fenaux and B. Choufi and S. Cheze and D. Klepping and B. Salles and {de Renzis}, B. and L. Willems and {De Prost}, D. and J. Gutnecht and S. Courby and V. Siguret and G. Tertian and L. Pascal and M. Chaury and E. Wattel and A. Guerci and L. Legros and R. Itzykson and L. Ades and F. Isnard and L. Sanhes and R. Benramdane and A. Stamatoullas and S. Am{\'e} and O. Beyne-Rauzy and E. Gyan and U. Platzbecker and C. Badrakan and U. Germing and M. L{\"u}bbert and R. Schlenk and I. Kotsianidis and C. Tsatalas and V. Pappa and A. Galanopoulos and E. Michali and P. Panagiotidis and N. Viniou and A. Katsigiannis and P. Roussou and E. Terpos and A. Kostourou and Z. Kartasis and A. Pouli and K. Palla and V. Briasoulis and E. Hatzimichael and G. Vassilopoulos and A. Symeonidis and A. Kourakli and P. Zikos and A. Anagnostopoulos and M. Kotsopoulou and K. Megalakaki and M. Protopapa and E. Vlachaki and P. Konstantinidou and G. Stemer and A. Nemetz and U. Gotwin and O. Cohen and M. Koren and E. Levy and U. Greenbaum and S. Gino-Moor and M. Price and Y. Ofran and A. Winder and N. Goldshmidt and S. Elias and R. Sabag and I. Hellman and M. Ellis and A. Braester and H. Rosenbaum and S. Berdichevsky and G. Itzhaki and O. Wolaj and S. Yeganeh and O. Katz and K. Filanovsky and N. Dali and M. Mittelman and L. Malcovati and L. Fianchi and {vd Loosdrecht}, A. and V. Matthijssen and A. Herbers and H. Pruijt and N. Aboosy and {de Vries}, F. and G. Velders and E. Jacobs and S. Langemeijer and M. MacKenzie and C. Lensen and P. Kuijper and K. Madry and M. Camara and A. Almeida and G. Vulkan and {Stanca Ciocan}, O. and A. Tatic and A. Savic and C. Pedro and B. Xicoy and P. Leiva and J. Munoz and V. Betes and C. Benavente and M. Lozano and M. Martinez and P. Iniesta and T. Bernal and {Diez Campelo}, M. and D. Tormo and {Andreu Lapiedra}, R. and G. Sanz and {Hesse Sundin}, E. and H. Garelius and C. Karlsson and P. Antunovic and A. J{\"o}nsson and L. Brandefors and L. Nilsson and P. Kozlowski and E. Hellstrom-Lindberg and M. Gr{\"o}vdal and K. Larsson and J. Wallvik and F. Lorenz and E. Ejerblad and D. Culligan and C. Craddock and S. Kolade and P. Cahalin and S. Killick and S. Ackroyd and C. Wong and A. Warren and M. Drummond and C. Hall and K. Rothwell and S. Green and S. Ali and M. Karakantza and M. Dennis and G. Jones and J. Parker and A. Bowen and R. Radia and E. Das-Gupta and P. Vyas and E. Nga and D. Creagh and J. Ashcroft and J. Mills and L. Bond and {the EUMDS Registry Participants}",

year = "2021",

month = jun,

doi = "10.1038/s41375-020-01022-2",

language = "English",

volume = "35",

pages = "1745--1750",

journal = "Leukemia",

issn = "0887-6924",

publisher = "Nature Publishing Group",

number = "6",

}

Hoeks, M, Bagguley, T, van Marrewijk, C, Smith, A, Bowen, D, Culligan, D, Kolade, S, Symeonidis, A, Garelius, H, Spanoudakis, M, Langemeijer, S, Roelofs, R, Wiegerinck, E, Tatic, A, Killick, S, Panagiotidis, P, Stanca, O, Hellström-Lindberg, E, Cermak, J, van der Klauw, M, Wouters, H, van Kraaij, M, Blijlevens, N, Swinkels, DW, de Witte, T, Stauder, R, Walder, A, Pfeilstöcker, M, Schoenmetzler-Makrai, A, Burgstaller, S, Thaler, J, Mandac Rogulj, I, Krejci, M, Voglova, J, Rohon, P, Jonasova, A, Cermak, J, Mikulenkova, D, Hochova, I, Jensen, PD, Holm, MS, Kjeldsen, L, Dufva, IH, Vestergaard, H, Re, D, Slama, B, Fenaux, P, Choufi, B, Cheze, S, Klepping, D, Salles, B, de Renzis, B, Willems, L, De Prost, D, Gutnecht, J, Courby, S, Siguret, V, Tertian, G, Pascal, L, Chaury, M, Wattel, E, Guerci, A, Legros, L, Itzykson, R, Ades, L, Isnard, F, Sanhes, L, Benramdane, R, Stamatoullas, A, Amé, S, Beyne-Rauzy, O, Gyan, E, Platzbecker, U, Badrakan, C, Germing, U, Lübbert, M, Schlenk, R, Kotsianidis, I, Tsatalas, C, Pappa, V, Galanopoulos, A, Michali, E, Panagiotidis, P, Viniou, N, Katsigiannis, A, Roussou, P, Terpos, E, Kostourou, A, Kartasis, Z, Pouli, A, Palla, K, Briasoulis, V, Hatzimichael, E, Vassilopoulos, G, Symeonidis, A, Kourakli, A, Zikos, P, Anagnostopoulos, A, Kotsopoulou, M, Megalakaki, K, Protopapa, M, Vlachaki, E, Konstantinidou, P, Stemer, G, Nemetz, A, Gotwin, U, Cohen, O, Koren, M, Levy, E, Greenbaum, U, Gino-Moor, S, Price, M, Ofran, Y, Winder, A, Goldshmidt, N, Elias, S, Sabag, R, Hellman, I, Ellis, M, Braester, A, Rosenbaum, H, Berdichevsky, S, Itzhaki, G, Wolaj, O, Yeganeh, S, Katz, O, Filanovsky, K, Dali, N, Mittelman, M, Malcovati, L, Fianchi, L, vd Loosdrecht, A, Matthijssen, V, Herbers, A, Pruijt, H, Aboosy, N, de Vries, F, Velders, G, Jacobs, E, Langemeijer, S, MacKenzie, M, Lensen, C, Kuijper, P, Madry, K, Camara, M, Almeida, A, Vulkan, G, Stanca Ciocan, O, Tatic, A, Savic, A, Pedro, C, Xicoy, B, Leiva, P, Munoz, J, Betes, V, Benavente, C, Lozano, M, Martinez, M, Iniesta, P, Bernal, T, Diez Campelo, M, Tormo, D, Andreu Lapiedra, R, Sanz, G, Hesse Sundin, E, Garelius, H, Karlsson, C, Antunovic, P, Jönsson, A, Brandefors, L, Nilsson, L, Kozlowski, P, Hellstrom-Lindberg, E, Grövdal, M, Larsson, K, Wallvik, J, Lorenz, F, Ejerblad, E, Culligan, D, Craddock, C, Kolade, S, Cahalin, P, Killick, S, Ackroyd, S, Wong, C, Warren, A, Drummond, M, Hall, C, Rothwell, K, Green, S, Ali, S, Karakantza, M, Dennis, M, Jones, G, Parker, J, Bowen, A, Radia, R, Das-Gupta, E, Vyas, P, Nga, E, Creagh, D, Ashcroft, J, Mills, J, Bond, L & the EUMDS Registry Participants 2021, 'Toxic iron species in lower-risk myelodysplastic syndrome patients: course of disease and effects on outcome', Leukemia, vol. 35, no. 6, pp. 1745-1750. https://doi.org/10.1038/s41375-020-01022-2

TY - JOUR

T1 - Toxic iron species in lower-risk myelodysplastic syndrome patients

T2 - course of disease and effects on outcome

AU - Hoeks, Marlijn

AU - Bagguley, Tim

AU - van Marrewijk, Corine

AU - Smith, Alex

AU - Bowen, David

AU - Culligan, Dominic

AU - Kolade, Seye

AU - Symeonidis, Argiris

AU - Garelius, Hege

AU - Spanoudakis, Michail

AU - Langemeijer, Saskia

AU - Roelofs, Rian

AU - Wiegerinck, Erwin

AU - Tatic, Aurelia

AU - Killick, Sally

AU - Panagiotidis, Panagiotis

AU - Stanca, Oana

AU - Hellström-Lindberg, Eva

AU - Cermak, Jaroslav

AU - van der Klauw, Melanie

AU - Wouters, Hanneke

AU - van Kraaij, Marian

AU - Blijlevens, Nicole

AU - Swinkels, Dorine W.

AU - de Witte, Theo

AU - Stauder, R.

AU - Walder, A.

AU - Pfeilstöcker, M.

AU - Schoenmetzler-Makrai, A.

AU - Burgstaller, S.

AU - Thaler, J.

AU - Mandac Rogulj, I.

AU - Krejci, M.

AU - Voglova, J.

AU - Rohon, P.

AU - Jonasova, A.

AU - Cermak, J.

AU - Mikulenkova, D.

AU - Hochova, I.

AU - Jensen, P. D.

AU - Holm, M. S.

AU - Kjeldsen, L.

AU - Dufva, I. H.

AU - Vestergaard, H.

AU - Re, D.

AU - Slama, B.

AU - Fenaux, P.

AU - Choufi, B.

AU - Cheze, S.

AU - Klepping, D.

AU - Salles, B.

AU - de Renzis, B.

AU - Willems, L.

AU - De Prost, D.

AU - Gutnecht, J.

AU - Courby, S.

AU - Siguret, V.

AU - Tertian, G.

AU - Pascal, L.

AU - Chaury, M.

AU - Wattel, E.

AU - Guerci, A.

AU - Legros, L.

AU - Itzykson, R.

AU - Ades, L.

AU - Isnard, F.

AU - Sanhes, L.

AU - Benramdane, R.

AU - Stamatoullas, A.

AU - Amé, S.

AU - Beyne-Rauzy, O.

AU - Gyan, E.

AU - Platzbecker, U.

AU - Badrakan, C.

AU - Germing, U.

AU - Lübbert, M.

AU - Schlenk, R.

AU - Kotsianidis, I.

AU - Tsatalas, C.

AU - Pappa, V.

AU - Galanopoulos, A.

AU - Michali, E.

AU - Panagiotidis, P.

AU - Viniou, N.

AU - Katsigiannis, A.

AU - Roussou, P.

AU - Terpos, E.

AU - Kostourou, A.

AU - Kartasis, Z.

AU - Pouli, A.

AU - Palla, K.

AU - Briasoulis, V.

AU - Hatzimichael, E.

AU - Vassilopoulos, G.

AU - Symeonidis, A.

AU - Kourakli, A.

AU - Zikos, P.

AU - Anagnostopoulos, A.

AU - Kotsopoulou, M.

AU - Megalakaki, K.

AU - Protopapa, M.

AU - Vlachaki, E.

AU - Konstantinidou, P.

AU - Stemer, G.

AU - Nemetz, A.

AU - Gotwin, U.

AU - Cohen, O.

AU - Koren, M.

AU - Levy, E.

AU - Greenbaum, U.

AU - Gino-Moor, S.

AU - Price, M.

AU - Ofran, Y.

AU - Winder, A.

AU - Goldshmidt, N.

AU - Elias, S.

AU - Sabag, R.

AU - Hellman, I.

AU - Ellis, M.

AU - Braester, A.

AU - Rosenbaum, H.

AU - Berdichevsky, S.

AU - Itzhaki, G.

AU - Wolaj, O.

AU - Yeganeh, S.

AU - Katz, O.

AU - Filanovsky, K.

AU - Dali, N.

AU - Mittelman, M.

AU - Malcovati, L.

AU - Fianchi, L.

AU - vd Loosdrecht, A.

AU - Matthijssen, V.

AU - Herbers, A.

AU - Pruijt, H.

AU - Aboosy, N.

AU - de Vries, F.

AU - Velders, G.

AU - Jacobs, E.

AU - Langemeijer, S.

AU - MacKenzie, M.

AU - Lensen, C.

AU - Kuijper, P.

AU - Madry, K.

AU - Camara, M.

AU - Almeida, A.

AU - Vulkan, G.

AU - Stanca Ciocan, O.

AU - Tatic, A.

AU - Savic, A.

AU - Pedro, C.

AU - Xicoy, B.

AU - Leiva, P.

AU - Munoz, J.

AU - Betes, V.

AU - Benavente, C.

AU - Lozano, M.

AU - Martinez, M.

AU - Iniesta, P.

AU - Bernal, T.

AU - Diez Campelo, M.

AU - Tormo, D.

AU - Andreu Lapiedra, R.

AU - Sanz, G.

AU - Hesse Sundin, E.

AU - Garelius, H.

AU - Karlsson, C.

AU - Antunovic, P.

AU - Jönsson, A.

AU - Brandefors, L.

AU - Nilsson, L.

AU - Kozlowski, P.

AU - Hellstrom-Lindberg, E.

AU - Grövdal, M.

AU - Larsson, K.

AU - Wallvik, J.

AU - Lorenz, F.

AU - Ejerblad, E.

AU - Culligan, D.

AU - Craddock, C.

AU - Kolade, S.

AU - Cahalin, P.

AU - Killick, S.

AU - Ackroyd, S.

AU - Wong, C.

AU - Warren, A.

AU - Drummond, M.

AU - Hall, C.

AU - Rothwell, K.

AU - Green, S.

AU - Ali, S.

AU - Karakantza, M.

AU - Dennis, M.

AU - Jones, G.

AU - Parker, J.

AU - Bowen, A.

AU - Radia, R.

AU - Das-Gupta, E.

AU - Vyas, P.

AU - Nga, E.

AU - Creagh, D.

AU - Ashcroft, J.

AU - Mills, J.

AU - Bond, L.

AU - the EUMDS Registry Participants

PY - 2021/6

Y1 - 2021/6

UR - http://www.scopus.com/inward/record.url?scp=85091002113&partnerID=8YFLogxK

U2 - 10.1038/s41375-020-01022-2

DO - 10.1038/s41375-020-01022-2

M3 - Journal article

C2 - 32948844

AN - SCOPUS:85091002113

SN - 0887-6924

VL - 35

SP - 1745

EP - 1750

JO - Leukemia

JF - Leukemia

IS - 6

ER -

Toxic iron species in lower-risk myelodysplastic syndrome patients: course of disease and effects on outcome

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