TRALI is an overlooked severe complication related to blood transfusion

Thure Mors Haunstrup, John Baech, Kim Varming, Bodil Steen Rasmussen, Kaspar René Nielsen

Research output: Contribution to journalReview articlepeer-review

Abstract

Transfusion-related acute lung injury (TRALI) is recognized as the most frequent cause of transfusion-related severe morbidity and mortality. TRALI is characterized by post-transfusional respiratory distress, hypoxaemia and radiographic verified lung infiltration, in the absence of sign of circulatory overload. TRALI is predominantly triggered by human leukocyte antigen or human neutrophil antigen (HNA) antibodies from the transfused blood component. Particularly antibodies against the HNA-3a are involved in severe and fatal TRALI cases. The serological investigation is important to trace and exclude blood donors with TRALI antibodies.

Original languageEnglish
JournalUgeskrift for laeger
Volume176
Issue number7
ISSN0041-5782
Publication statusPublished - 31 Mar 2014

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