TY - JOUR
T1 - Transcranial Magnetic Stimulation to Address Mild Cognitive Impairment in the Elderly
T2 - A Randomized Controlled Study
AU - Drumond Marra, Hellen Livia
AU - Myczkowski, Martin Luiz
AU - Maia Memória, Cláudia
AU - Arnaut, Débora
AU - Leite Ribeiro, Philip
AU - Sardinha Mansur, Carlos Gustavo
AU - Lancelote Alberto, Rodrigo
AU - Boura Bellini, Bianca
AU - Alves Fernandes da Silva, Adriano
AU - Tortella, Gabriel
AU - Ciampi de Andrade, Daniel
AU - Teixeira, Manoel Jacobsen
AU - Forlenza, Orestes Vicente
AU - Marcolin, Marco Antonio
PY - 2015
Y1 - 2015
N2 - Transcranial magnetic stimulation (TMS) is a noninvasive brain stimulation technique with potential to improve memory. Mild cognitive impairment (MCI), which still lacks a specific therapy, is a clinical syndrome associated with increased risk of dementia. This study aims to assess the effects of high-frequency repetitive TMS (HF rTMS) on everyday memory of the elderly with MCI. We conducted a double-blinded randomized sham-controlled trial using rTMS over the left dorsolateral prefrontal cortex (DLPFC). Thirty-four elderly outpatients meeting Petersen's MCI criteria were randomly assigned to receive 10 sessions of either active TMS or sham, 10 Hz rTMS at 110% of motor threshold, 2,000 pulses per session. Neuropsychological assessment at baseline, after the last session (10th) and at one-month follow-up, was applied. ANOVA on the primary efficacy measure, the Rivermead Behavioural Memory Test, revealed a significant group-by-time interaction (p = 0.05), favoring the active group. The improvement was kept after one month. Other neuropsychological tests were heterogeneous. rTMS at 10 Hz enhanced everyday memory in elderly with MCI after 10 sessions. These findings suggest that rTMS might be effective as a therapy for MCI and probably a tool to delay deterioration.
AB - Transcranial magnetic stimulation (TMS) is a noninvasive brain stimulation technique with potential to improve memory. Mild cognitive impairment (MCI), which still lacks a specific therapy, is a clinical syndrome associated with increased risk of dementia. This study aims to assess the effects of high-frequency repetitive TMS (HF rTMS) on everyday memory of the elderly with MCI. We conducted a double-blinded randomized sham-controlled trial using rTMS over the left dorsolateral prefrontal cortex (DLPFC). Thirty-four elderly outpatients meeting Petersen's MCI criteria were randomly assigned to receive 10 sessions of either active TMS or sham, 10 Hz rTMS at 110% of motor threshold, 2,000 pulses per session. Neuropsychological assessment at baseline, after the last session (10th) and at one-month follow-up, was applied. ANOVA on the primary efficacy measure, the Rivermead Behavioural Memory Test, revealed a significant group-by-time interaction (p = 0.05), favoring the active group. The improvement was kept after one month. Other neuropsychological tests were heterogeneous. rTMS at 10 Hz enhanced everyday memory in elderly with MCI after 10 sessions. These findings suggest that rTMS might be effective as a therapy for MCI and probably a tool to delay deterioration.
KW - Aged
KW - Cognitive Dysfunction/therapy
KW - Female
KW - Humans
KW - Male
KW - Memory/physiology
KW - Middle Aged
KW - Motor Cortex/physiopathology
KW - Neuropsychological Tests
KW - Prefrontal Cortex/physiopathology
KW - Transcranial Magnetic Stimulation/methods
KW - Treatment Outcome
U2 - 10.1155/2015/287843
DO - 10.1155/2015/287843
M3 - Journal article
C2 - 26160997
SN - 0953-4180
VL - 2015
JO - Behavioural Neurology
JF - Behavioural Neurology
M1 - 287843
ER -