Transcriptional signatures of regulatory and toxic responses to benzo-[a]-pyrene exposure

Jacob J Michaelson; Saskia Trump; Susanne Rudzok; Carolin Gräbsch; Danielle J Madureira; Franziska Dautel; Juliane Mai; Sabine Attinger; Kristin Schirmer; Martin von Bergen; Irina Lehmann; Andreas Beyer; Martin von Bergen

doi:10.1186/1471-2164-12-502

Transcriptional signatures of regulatory and toxic responses to benzo-[a]-pyrene exposure

Jacob J Michaelson, Saskia Trump, Susanne Rudzok, Carolin Gräbsch, Danielle J Madureira, Franziska Dautel, Juliane Mai, Sabine Attinger, Kristin Schirmer, Martin von Bergen, Irina Lehmann, Andreas Beyer, Martin von Bergen

Research output: Contribution to journal › Journal article › Research › peer-review

26 Citations (Scopus)

Abstract

Small molecule ligands often have multiple effects on the transcriptional program of a cell: they trigger a receptor specific response and additional, indirect responses ("side effects"). Distinguishing those responses is important for understanding side effects of drugs and for elucidating molecular mechanisms of toxic chemicals.

Original language	English
Journal	B M C Genomics
Volume	12
Pages (from-to)	502
ISSN	1471-2164
DOIs	https://doi.org/10.1186/1471-2164-12-502
Publication status	Published - 2011
Externally published	Yes

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title = "Transcriptional signatures of regulatory and toxic responses to benzo-[a]-pyrene exposure",

abstract = "Small molecule ligands often have multiple effects on the transcriptional program of a cell: they trigger a receptor specific response and additional, indirect responses ({"}side effects{"}). Distinguishing those responses is important for understanding side effects of drugs and for elucidating molecular mechanisms of toxic chemicals.",

author = "Michaelson, {Jacob J} and Saskia Trump and Susanne Rudzok and Carolin Gr{\"a}bsch and Madureira, {Danielle J} and Franziska Dautel and Juliane Mai and Sabine Attinger and Kristin Schirmer and {von Bergen}, Martin and Irina Lehmann and Andreas Beyer and {von Bergen}, Martin",

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T1 - Transcriptional signatures of regulatory and toxic responses to benzo-[a]-pyrene exposure

AU - Michaelson, Jacob J

AU - Trump, Saskia

AU - Rudzok, Susanne

AU - Gräbsch, Carolin

AU - Madureira, Danielle J

AU - Dautel, Franziska

AU - Mai, Juliane

AU - Attinger, Sabine

AU - Schirmer, Kristin

AU - von Bergen, Martin

AU - Lehmann, Irina

AU - Beyer, Andreas

AU - von Bergen, Martin

PY - 2011

Y1 - 2011

N2 - Small molecule ligands often have multiple effects on the transcriptional program of a cell: they trigger a receptor specific response and additional, indirect responses ("side effects"). Distinguishing those responses is important for understanding side effects of drugs and for elucidating molecular mechanisms of toxic chemicals.

AB - Small molecule ligands often have multiple effects on the transcriptional program of a cell: they trigger a receptor specific response and additional, indirect responses ("side effects"). Distinguishing those responses is important for understanding side effects of drugs and for elucidating molecular mechanisms of toxic chemicals.

U2 - 10.1186/1471-2164-12-502

DO - 10.1186/1471-2164-12-502

M3 - Journal article

C2 - 21995607

SN - 1471-2164

VL - 12

SP - 502

JO - B M C Genomics

JF - B M C Genomics

ER -

Transcriptional signatures of regulatory and toxic responses to benzo-[a]-pyrene exposure

Abstract

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