Transkateteraortaklapimplantation i Danmark

Troels Højsgaard Jørgensen; Ole De Backer; Henrik Nissen; Poul Erik Mortensen; Kaj-Erik Klaaborg; Jens Aarøe; Evald Høj Christiansen; Lars Søndergaard

Transkateteraortaklapimplantation i Danmark

Translated title of the contribution: Combination therapy of thyroxine and triiodothyronine in hypothyroid patients

Troels Højsgaard Jørgensen, Ole De Backer, Henrik Nissen, Poul Erik Mortensen, Kaj-Erik Klaaborg, Jens Aarøe, Evald Høj Christiansen, Lars Søndergaard

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Decreased quality of life is described more often in hypothyroid patients, who are treated with a synthetic form of thyroxine (L-T4), than in euthyroid controls. A combination of L-T4 and a synthetic form of triiodothyronine (L-T3) has been suggested; however, previous meta-analyses on unselected patients did not find any effect. Recent studies demonstrate, that the overall hypothalamic-pituitary-thyroid-tissue homeostasis could be more complex than previously suggested. Polymorphisms in deiodinase and thyroid hormone transporter genes could theoretically explain, why a minor subgroup of hypothyroid patients seem to have an effect of L-T4/L-T3 combination therapy.

Translated title of the contribution	Combination therapy of thyroxine and triiodothyronine in hypothyroid patients
Original language	Danish
Article number	V05180340
Journal	Ugeskrift for Laeger
Volume	180
Issue number	20A
Pages (from-to)	1843-1846
Number of pages	4
ISSN	0041-5782
Publication status	Published - 2018

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@article{3a2729ed1512464dbe8efd2e22884250,

title = "Transkateteraortaklapimplantation i Danmark",

abstract = "Decreased quality of life is described more often in hypothyroid patients, who are treated with a synthetic form of thyroxine (L-T4), than in euthyroid controls. A combination of L-T4 and a synthetic form of triiodothyronine (L-T3) has been suggested; however, previous meta-analyses on unselected patients did not find any effect. Recent studies demonstrate, that the overall hypothalamic-pituitary-thyroid-tissue homeostasis could be more complex than previously suggested. Polymorphisms in deiodinase and thyroid hormone transporter genes could theoretically explain, why a minor subgroup of hypothyroid patients seem to have an effect of L-T4/L-T3 combination therapy.",

author = "{H{\o}jsgaard J{\o}rgensen}, Troels and {De Backer}, Ole and Henrik Nissen and Mortensen, {Poul Erik} and Kaj-Erik Klaaborg and Jens Aar{\o}e and {H{\o}j Christiansen}, Evald and Lars S{\o}ndergaard",

year = "2018",

language = "Dansk",

volume = "180",

pages = "1843--1846",

journal = "Ugeskrift for Laeger",

issn = "0041-5782",

publisher = "Almindelige Danske Laegeforening",

number = "20A",

}

TY - JOUR

T1 - Transkateteraortaklapimplantation i Danmark

AU - Højsgaard Jørgensen, Troels

AU - De Backer, Ole

AU - Nissen, Henrik

AU - Mortensen, Poul Erik

AU - Klaaborg, Kaj-Erik

AU - Aarøe, Jens

AU - Høj Christiansen, Evald

AU - Søndergaard, Lars

PY - 2018

Y1 - 2018

N2 - Decreased quality of life is described more often in hypothyroid patients, who are treated with a synthetic form of thyroxine (L-T4), than in euthyroid controls. A combination of L-T4 and a synthetic form of triiodothyronine (L-T3) has been suggested; however, previous meta-analyses on unselected patients did not find any effect. Recent studies demonstrate, that the overall hypothalamic-pituitary-thyroid-tissue homeostasis could be more complex than previously suggested. Polymorphisms in deiodinase and thyroid hormone transporter genes could theoretically explain, why a minor subgroup of hypothyroid patients seem to have an effect of L-T4/L-T3 combination therapy.

AB - Decreased quality of life is described more often in hypothyroid patients, who are treated with a synthetic form of thyroxine (L-T4), than in euthyroid controls. A combination of L-T4 and a synthetic form of triiodothyronine (L-T3) has been suggested; however, previous meta-analyses on unselected patients did not find any effect. Recent studies demonstrate, that the overall hypothalamic-pituitary-thyroid-tissue homeostasis could be more complex than previously suggested. Polymorphisms in deiodinase and thyroid hormone transporter genes could theoretically explain, why a minor subgroup of hypothyroid patients seem to have an effect of L-T4/L-T3 combination therapy.

M3 - Tidsskriftartikel

SN - 0041-5782

VL - 180

SP - 1843

EP - 1846

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 20A

M1 - V05180340

ER -

Transkateteraortaklapimplantation i Danmark

Abstract

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