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Abstract
Objectives: Irreversible electroporation (IRE) is a novel non-thermal ablative technique applied in the treatment of unresectable locally advanced pancreatic cancer (LAPC). This paper reports on the initial experience with IRE of unresectable LAPC in our institution.
Methods: From October 2013 to March 2018, patients with unresectable LAPC referred for IRE at the Department of Gastrointestinal Surgery, Aalborg University Hospital, were considered for inclusion in the study. Ninety-day morbidity, 30-day mortality, pain score, length of hospital stay (LOS) and overall survival (OS) were recorded.
Results: We included 33 patients receiving 40 IRE ablations in total. The median visual analogue scale (VAS)-score was four (range 0–10) two hours after IRE, and one (range 0–8) eight hours after IRE. The median LOS was one day (range 1–13 days). Post-procedural complications occurred in 21 of 40 ablations (53%), of which eight (20%) were major (Clavien–Dindo grade III or more). A proportion of the observed complications might be attributed to disease progression and not IRE per se. Although not statistically significant, we observed increased severity of complications in tumors above 3.5 cm. The 30-day mortality was 5% (2/40). The median OS was 10.7 months (range 0.6–53.8 months) from the initial IRE procedure, and 18.5 months (range 4.9–65.8 months) from time of diagnosis.
Conclusions: In our institution, IRE seems as a feasible consolidative treatment of unresectable LAPC with an acceptable safety profile. The oncological outcome of IRE in patients with unresectable LAPC is to be further evaluated in a planned phase 2 clinical trial (CHEMOFIRE-2).
Methods: From October 2013 to March 2018, patients with unresectable LAPC referred for IRE at the Department of Gastrointestinal Surgery, Aalborg University Hospital, were considered for inclusion in the study. Ninety-day morbidity, 30-day mortality, pain score, length of hospital stay (LOS) and overall survival (OS) were recorded.
Results: We included 33 patients receiving 40 IRE ablations in total. The median visual analogue scale (VAS)-score was four (range 0–10) two hours after IRE, and one (range 0–8) eight hours after IRE. The median LOS was one day (range 1–13 days). Post-procedural complications occurred in 21 of 40 ablations (53%), of which eight (20%) were major (Clavien–Dindo grade III or more). A proportion of the observed complications might be attributed to disease progression and not IRE per se. Although not statistically significant, we observed increased severity of complications in tumors above 3.5 cm. The 30-day mortality was 5% (2/40). The median OS was 10.7 months (range 0.6–53.8 months) from the initial IRE procedure, and 18.5 months (range 4.9–65.8 months) from time of diagnosis.
Conclusions: In our institution, IRE seems as a feasible consolidative treatment of unresectable LAPC with an acceptable safety profile. The oncological outcome of IRE in patients with unresectable LAPC is to be further evaluated in a planned phase 2 clinical trial (CHEMOFIRE-2).
Original language | English |
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Journal | Scandinavian Journal of Gastroenterology |
Volume | 54 |
Issue number | 2 |
Pages (from-to) | 252-258 |
Number of pages | 7 |
ISSN | 0036-5521 |
DOIs | |
Publication status | Published - 1 Feb 2019 |
Keywords
- Irreversible electroporation
- locally advanced pancreatic cancer
- nanoknife
- pancreas
- tumor ablation
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Dive into the research topics of 'Treatment of locally advanced pancreatic cancer with irreversible electroporation – a Danish single center study of safety and feasibility'. Together they form a unique fingerprint.Projects
- 1 Finished
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Therapeutic potential of irreversible electroporation in pancreatic cancer
Flak, R. V., Thorlacius-Ussing, O., Stender, M. T. & Petersen, L. M. J.
01/01/2019 → 31/12/2021
Project: Research
Activities
- 2 Conference presentations
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Treatment of locally advanced pancreatic cancer with irreversible electroporation - a Danish single center study of safety and feasibility
Rasmus Virenfeldt Flak (Lecturer)
3 Sept 2019Activity: Talks and presentations › Conference presentations
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Treatment of locally advanced pancreatic cancer with irreversible electroporation - a Danish single center study of safety and feasibility
Rasmus Virenfeldt Flak (Lecturer)
29 Aug 2019Activity: Talks and presentations › Conference presentations
Prizes
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ISEBTT early career investigator award for research of exceptional quality
Flak, Rasmus Virenfeldt (Recipient), 6 Sept 2019
Prize: Conference prizes
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