TY - JOUR
T1 - Trimethoprim use prior to pregnancy and the risk of congenital malformation
T2 - a register-based nationwide cohort study
AU - Andersen, Jon Trærup
AU - Petersen, Morten
AU - Jimenez-Solem, Espen
AU - Rasmussen, Jeppe Nørgaard
AU - Andersen, Nadia Lyhne
AU - Afzal, Shoaib
AU - Broedbaek, Kasper
AU - Hjelvang, Brian Rafn
AU - Køber, Lars
AU - Torp-Pedersen, Christian
AU - Poulsen, Henrik Enghusen
PY - 2013
Y1 - 2013
N2 - Objectives. The aim of the study was to investigate whether the use of the antifolate antibiotic trimethoprim during the 12 weeks before conception was associated with congenital malformations. Methods. We conducted a nationwide register-based cohort study including all Danish women giving birth from 1997 to 2004. All women with at least one prescription of trimethoprim dispensed during the 12 weeks before conception were identified. Results. There was a doubling of congenital malformations in offspring to women exposed to trimethoprim in the 12 weeks before conception. The adjusted odds ratio (OR) of major congenital malformation was 1.87, 95% confidence interval (CI) 1.25-2.81. There was a significant increase in major malformations of the heart (OR = 2.49; 1.18-5.26) and limbs (OR = 2.18; 1.13-4.23). Conclusions. In this study, we found an association between exposure to trimethoprim during the 12 weeks before conception and an increased risk of heart and limb defects.
AB - Objectives. The aim of the study was to investigate whether the use of the antifolate antibiotic trimethoprim during the 12 weeks before conception was associated with congenital malformations. Methods. We conducted a nationwide register-based cohort study including all Danish women giving birth from 1997 to 2004. All women with at least one prescription of trimethoprim dispensed during the 12 weeks before conception were identified. Results. There was a doubling of congenital malformations in offspring to women exposed to trimethoprim in the 12 weeks before conception. The adjusted odds ratio (OR) of major congenital malformation was 1.87, 95% confidence interval (CI) 1.25-2.81. There was a significant increase in major malformations of the heart (OR = 2.49; 1.18-5.26) and limbs (OR = 2.18; 1.13-4.23). Conclusions. In this study, we found an association between exposure to trimethoprim during the 12 weeks before conception and an increased risk of heart and limb defects.
U2 - 10.1155/2013/364526
DO - 10.1155/2013/364526
M3 - Journal article
C2 - 23476656
SN - 1687-9589
VL - 2013
SP - Article No. 364526
JO - Obstetrics and Gynecology International
JF - Obstetrics and Gynecology International
ER -