Undefeated-Changing the phenamacril scaffold is not enough to beat resistant Fusarium

Rasmus D. Wollenberg, Søren S. Donau, Manuel H. Taft, Zoltan Balázs, Sven Giese, Claudia Thiel, Jens L. Sørensen, Thorbjørn T. Nielsen, Henriette Giese, Dietmar J. Manstein, Reinhard Wimmer, Teis E. Sondergaard

Research output: Contribution to journalJournal articleResearchpeer-review

2 Citations (Scopus)
59 Downloads (Pure)

Abstract

Filamentous fungi belonging to the genus Fusarium are notorious plant-pathogens that infect, damage and contaminate a wide variety of important crops. Phenamacril is the first member of a novel class of single-site acting cyanoacrylate fungicides which has proven highly effective against important members of the genus Fusarium. However, the recent emergence of field-resistant strains exhibiting qualitative resistance poses a major obstacle for the continued use of phenamacril. In this study, we synthesized novel cyanoacrylate compounds based on the phenamacril-scaffold to test their growth-inhibitory potential against wild-type Fusarium and phenamacril-resistant strains. Our findings show that most chemical modifications to the phenamacril-scaffold are associated with almost complete loss of fungicidal activity and in vitro inhibition of myosin motor domain ATPase activity.

Original languageEnglish
Article numbere0235568
JournalPLOS ONE
Volume15
Issue number6
ISSN1932-6203
DOIs
Publication statusPublished - Jun 2020

Keywords

  • Cyanoacrylates/pharmacology
  • Drug Resistance, Fungal/drug effects
  • Fungicides, Industrial/pharmacology
  • Fusarium/drug effects

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