TY - JOUR
T1 - Understanding the sensory irregularities of esophageal disease
AU - Farmer, Adam D
AU - Brock, Christina
AU - Frøkjaer, Jens Brøndum
AU - Gregersen, Hans
AU - Khan, Sheeba
AU - Lelic, Dina
AU - Lottrup, Christian
AU - Drewes, Asbjørn Mohr
PY - 2016/2/18
Y1 - 2016/2/18
N2 - Symptoms relating to esophageal sensory abnormalities can be encountered in the clinical environment. Such sensory abnormalities may be present in demonstrable disease, such as erosive esophagitis, and in the ostensibly normal esophagus, such as non-erosive reflux disease or functional chest pain. In this review, the authors discuss esophageal sensation and the esophageal pain system. In addition, the authors provide a primer concerning the techniques that are available for investigating the autonomic nervous system, neuroimaging and neurophysiology of esophageal sensory function. Such technological advances, whilst not readily available in the clinic may facilitate the stratification and individualization of therapy in disorders of esophageal sensation in the future.
AB - Symptoms relating to esophageal sensory abnormalities can be encountered in the clinical environment. Such sensory abnormalities may be present in demonstrable disease, such as erosive esophagitis, and in the ostensibly normal esophagus, such as non-erosive reflux disease or functional chest pain. In this review, the authors discuss esophageal sensation and the esophageal pain system. In addition, the authors provide a primer concerning the techniques that are available for investigating the autonomic nervous system, neuroimaging and neurophysiology of esophageal sensory function. Such technological advances, whilst not readily available in the clinic may facilitate the stratification and individualization of therapy in disorders of esophageal sensation in the future.
U2 - 10.1586/17474124.2016.1155984
DO - 10.1586/17474124.2016.1155984
M3 - Review article
C2 - 26890720
SN - 1747-4124
VL - 10
SP - 907
EP - 914
JO - Expert Review of Gastroenterology & Hepatology
JF - Expert Review of Gastroenterology & Hepatology
IS - 8
ER -