Abstract
Objectives: Organic dust is associated with adverse effects on human airways. This study was done to investigate whether the addition of β-(1,3)-D glucan or aldehydes to office dust causes enhanced inflammation in human airways. Methods: Thirty-six volunteers were exposed randomly to clean air, office dust, dust spiked with glucan, and dust spiked with aldehydes. The three dust exposures contained between 332 and 379 μg dust/m3. Spiking with 1 gram of dust was done with 10 milligrams of glucan or 0.1 microliters of aldehydes. Acoustic rhinometry, rhinostereometry, nasal lavage, and lung function tests were applied. Results: After the exposures to dust spiked with the glucan and aldehydes, the nasal volume decreased (-1.33 and -1.39 cm3 (mean), respectively) when compared with the -0.9 cm3 after clean air or office dust (P=0.036 for a difference in decrease between exposures). After 2-3 hours the aldehyde-spiked dust caused a 0.6-mm swelling of the inferior turbinate, and glucan-spiked dust produced a 0.7-mm swelling (P=0.039 for a difference in the swelling between the four exposures). The preexposure nasal lavage cleaned off the mucosa, and lower cytokine concentrations were found after all of the exposures. For interleukin-8, this decrease in concentration was smaller after the dust exposures spiked with glucan and aldehydes (-2.9 and -25.8 pg/ml, respectively) than after office dust or clean air (-65.9 and -74.1 pg/ml, respectively) (P=0.042). The nasal eosinophil cell concentration increased after exposure to dust spiked with glucan (P=0.045). Conclusions: β-(1,3)-D glucan and aldehydes in office dust enhance the inflammatory effects of dust on the upper airways.
Original language | English |
---|---|
Journal | Scandinavian Journal of Work, Environment and Health |
Volume | 32 |
Issue number | 5 |
Pages (from-to) | 374-382 |
Number of pages | 9 |
ISSN | 0355-3140 |
DOIs | |
Publication status | Published - Oct 2006 |
Externally published | Yes |
Keywords
- Acoustic rhinometry
- Dust
- Eosinophil cationic protein
- Indoor air
- Interleukin 1
- Interleukin 8
- Nasal mucosa
- Rhinostereomety