Use of Fermented Red Clover Isoflavones in the Treatment of Overactive Bladder in Postmenopausal Women: A Randomized, Double-Blinded, Placebo-Controlled Trial

Annemarie B. Villadsen, Julie N. Holm-Jacobsen, Bala K. Prabhala, Caspar Bundgaard-Nielsen, Pam Huntjens, Jette B. Kornum, Karin Glavind, Peter D. C. Leutscher, Lars P. Christensen, Per B. Jeppesen, Suzette Sørensen, Louise T. S. Arenholt*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

Postmenopausal women are at risk of developing an overactive bladder (OAB). Conventional vaginal estrogen has shown promise for symptom relief. Isoflavones have proven effective as an alternative to estrogen treatment against menopause-related symptoms. However, its effect on OAB symptoms has not been studied. This study investigates if fermented red clover isoflavones reduce OAB symptoms in postmenopausal women. In this randomized, double-blinded, placebo-controlled trial, women were administered red clover extract (RCE) or a placebo twice daily for three months. Women filled out the International Consultation on Incontinence Questionnaire Overactive Bladder (ICIQ-OAB) and Urinary Incontinence Short Form (ICIQ-UI-SF), together with a fluid intake and voiding diary. A total of 33 women (16 in the RCE group and 17 in the placebo group) were included in the analysis. Baseline demographics and OAB characteristics were comparable across groups. Intake of RCE did not lead to significant relief in most urinary bladder symptom measures, although a significant reduction in the bother of urinary urgency (p = 0.033) and a tendency towards a decreased ICIQ-OAB score were observed (p = 0.056). In contrast, the placebo exhibited a significant decrease in the ICIQ-OAB score (p = 0.021) and in some diary outcomes. We found that an intake of isoflavones did not relieve OAB symptoms in postmenopausal women.

Original languageEnglish
Article number4165
JournalNutrients
Volume15
Issue number19
ISSN2072-6643
DOIs
Publication statusPublished - Oct 2023

Keywords

  • Estrogens/therapeutic use
  • Female
  • Humans
  • Postmenopause
  • Quality of Life
  • Surveys and Questionnaires
  • Treatment Outcome
  • Trifolium
  • Urinary Bladder
  • Urinary Bladder, Overactive/drug therapy
  • Urinary Incontinence
  • isoflavones
  • red clover
  • urinary incontinence
  • postmenopause
  • overactive bladder

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