Validation study of the early onset schizophrenia diagnosis in the Danish Psychiatric Central Research Register

Ditte Lammers Vernal, Anne Dorte Stenstrøm, Nina Staal, Anne Marie Raabjerg Christensen, Christine Ebbesen, Anne Katrine Pagsberg, Christoph U. Correll, René Ernst Nielsen, Marlene Briciet Lauritsen

Research output: Contribution to journalJournal articleResearchpeer-review

9 Citations (Scopus)

Abstract

The objective of this study is to assess (1) the concordance and validity of schizophrenia register diagnoses among children and adolescents (early onset schizophrenia = EOS) in the Danish Psychiatric Central Research Register (DPCRR), and (2) the validity of clinical record schizophrenia diagnoses. Psychiatric records from 200 patients with a first-time diagnosis of schizophrenia (F20.x) at age  0.78–0.83 depending on classification. Compared to diagnoses made in outpatient settings, EOS diagnoses during hospitalizations were more likely to be valid and had fewer registration errors. Diagnosed in inpatient settings, EOS diagnoses are reliable and valid for register-based research. Schizophrenia diagnosed in children and adolescents in outpatient settings were found to have a high number of false-positives, both due to registration errors and diagnostic practice. Utilizing this knowledge, it is possible to reduce the number of false-positives in register-based research of EOS.
Original languageEnglish
JournalEuropean Child & Adolescent Psychiatry
Volume27
Issue number8
Pages (from-to)965-975
Number of pages11
ISSN1435-165X
DOIs
Publication statusPublished - 2018

Keywords

  • Early onset schizophrenia
  • Register
  • Schizophrenia
  • Validity

Cite this