Valproate and palmitate binding to serum albumin in valproate-treated patients. Relation to obesity.

H Vorum, L Gram, B Honoré

Research output: Contribution to journalJournal articleResearchpeer-review

36 Citations (Scopus)

Abstract

Binding of valproate and palmitate to serum albumin was studied in 29 valproate-treated epileptic patients. The results were compared with similar observations in a reference group of 43 non valproate-treated individuals. The binding affinity for palmitate was decreased (P < 0.0001) resulting in increased availability of long-chain fatty acids (P = 0.008) due to competitive valproate binding in the valproate-treated patients. The findings support a hypothesis on the pathogenesis of obesity as a complication of valproate treatment of epilepsy.
Udgivelsesdato: 1993-Sep
Original languageEnglish
JournalEpilepsy Research
Volume16
Pages (from-to)55-64
Number of pages9
ISSN0920-1211
Publication statusPublished - 1993
Externally publishedYes

Keywords

  • Adult
  • Body Mass Index
  • Epilepsy
  • Fatty Acids, Nonesterified
  • Female
  • Humans
  • Male
  • Middle Aged
  • Models, Biological
  • Obesity
  • Palmitic Acid
  • Palmitic Acids
  • Protein Binding
  • Serum Albumin
  • Valproic Acid

Cite this

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title = "Valproate and palmitate binding to serum albumin in valproate-treated patients. Relation to obesity.",
abstract = "Binding of valproate and palmitate to serum albumin was studied in 29 valproate-treated epileptic patients. The results were compared with similar observations in a reference group of 43 non valproate-treated individuals. The binding affinity for palmitate was decreased (P < 0.0001) resulting in increased availability of long-chain fatty acids (P = 0.008) due to competitive valproate binding in the valproate-treated patients. The findings support a hypothesis on the pathogenesis of obesity as a complication of valproate treatment of epilepsy. Udgivelsesdato: 1993-Sep",
keywords = "Adult, Body Mass Index, Epilepsy, Fatty Acids, Nonesterified, Female, Humans, Male, Middle Aged, Models, Biological, Obesity, Palmitic Acid, Palmitic Acids, Protein Binding, Serum Albumin, Valproic Acid",
author = "H Vorum and L Gram and B Honor{\'e}",
year = "1993",
language = "English",
volume = "16",
pages = "55--64",
journal = "Epilepsy Research",
issn = "0920-1211",
publisher = "Elsevier",

}

Valproate and palmitate binding to serum albumin in valproate-treated patients. Relation to obesity. / Vorum, H; Gram, L; Honoré, B.

In: Epilepsy Research, Vol. 16, 1993, p. 55-64.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Valproate and palmitate binding to serum albumin in valproate-treated patients. Relation to obesity.

AU - Vorum, H

AU - Gram, L

AU - Honoré, B

PY - 1993

Y1 - 1993

N2 - Binding of valproate and palmitate to serum albumin was studied in 29 valproate-treated epileptic patients. The results were compared with similar observations in a reference group of 43 non valproate-treated individuals. The binding affinity for palmitate was decreased (P < 0.0001) resulting in increased availability of long-chain fatty acids (P = 0.008) due to competitive valproate binding in the valproate-treated patients. The findings support a hypothesis on the pathogenesis of obesity as a complication of valproate treatment of epilepsy. Udgivelsesdato: 1993-Sep

AB - Binding of valproate and palmitate to serum albumin was studied in 29 valproate-treated epileptic patients. The results were compared with similar observations in a reference group of 43 non valproate-treated individuals. The binding affinity for palmitate was decreased (P < 0.0001) resulting in increased availability of long-chain fatty acids (P = 0.008) due to competitive valproate binding in the valproate-treated patients. The findings support a hypothesis on the pathogenesis of obesity as a complication of valproate treatment of epilepsy. Udgivelsesdato: 1993-Sep

KW - Adult

KW - Body Mass Index

KW - Epilepsy

KW - Fatty Acids, Nonesterified

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Models, Biological

KW - Obesity

KW - Palmitic Acid

KW - Palmitic Acids

KW - Protein Binding

KW - Serum Albumin

KW - Valproic Acid

M3 - Journal article

VL - 16

SP - 55

EP - 64

JO - Epilepsy Research

JF - Epilepsy Research

SN - 0920-1211

ER -