TY - JOUR
T1 - Variation in the purinergic P2RX(7) receptor gene and schizophrenia.
AU - Hansen, Thomas
AU - Jakobsen, Klaus D
AU - Fenger, Mogens
AU - Nielsen, Jimmi
AU - Fink-Jensen, Anders
AU - Lublin, Henrik
AU - Krane, Karoline
AU - Ullum, Henrik
AU - Timm, Sally
AU - Wang, August G
AU - Jørgensen, Niklas Rye
AU - Werge, Thomas
PY - 2008
Y1 - 2008
N2 - INTRODUCTION: The purinergic receptor gene P2RX(7) is located in a major linkage hotspot for schizophrenia and bipolar disorders, 12q21-33. It has previously been associated with bipolar disorder but has never been analysed in relation to schizophrenia, although it is involved in several neuronal processes associated with schizophrenia. METHODS: Nine functionally characterised variants in P2RX(7) were genotyped in 389 patients diagnosed with schizophrenia, each matched on sex, birth-year and month with two healthy controls. RESULTS: We did not find association between P2RX(7) and schizophrenia and stratification on gender did not change this result. The high ethnic and diagnostic homogeneity of the sample adds credibility to this finding. CONCLUSION: P2XR(7) was not associated with schizophrenia in this study.
AB - INTRODUCTION: The purinergic receptor gene P2RX(7) is located in a major linkage hotspot for schizophrenia and bipolar disorders, 12q21-33. It has previously been associated with bipolar disorder but has never been analysed in relation to schizophrenia, although it is involved in several neuronal processes associated with schizophrenia. METHODS: Nine functionally characterised variants in P2RX(7) were genotyped in 389 patients diagnosed with schizophrenia, each matched on sex, birth-year and month with two healthy controls. RESULTS: We did not find association between P2RX(7) and schizophrenia and stratification on gender did not change this result. The high ethnic and diagnostic homogeneity of the sample adds credibility to this finding. CONCLUSION: P2XR(7) was not associated with schizophrenia in this study.
U2 - 10.1016/j.schres.2008.05.026
DO - 10.1016/j.schres.2008.05.026
M3 - Journal article
SN - 0920-9964
VL - 104
SP - 146
EP - 152
JO - Schizophrenia Research
JF - Schizophrenia Research
ER -