Very early changes in circulating T3 and rT3 during development of metabolic derangement in diabetic patients

S Madsbad; P Laurberg; J Weeke; H Orskov; O K Faber; C Binder; T Krarup; L Regeur

Very early changes in circulating T3 and rT3 during development of metabolic derangement in diabetic patients

S Madsbad, P Laurberg, J Weeke, H Orskov, O K Faber, C Binder, T Krarup, L Regeur

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Alterations in circulating iodothyronines were studied in 15 juvenile type diabetic patients during the development of metabolic derangement after withdrawal of insulin. By means of measurements of circulating C peptide, one group of patients with and one without residual beta-cell function had been selected. In both groups there was a gradual decrease in serum T3 during the 12-hour period studied after withdrawal of insulin, while an increase in serum rT3 was observed after 4-6 hours. The alterations in serum T3 and the metabolic derangement were significantly more pronounced in patients without than with residual beta-cell function.

Original language	English
Journal	ACTA MEDICA SCANDINAVICA
Volume	209
Issue number	5
Pages (from-to)	385-7
Number of pages	3
ISSN	0001-6101
Publication status	Published - 1981
Externally published	Yes

Keywords

C-Peptide
Diabetes Mellitus, Type 1
Humans
Insulin
Islets of Langerhans
Time Factors
Triiodothyronine
Triiodothyronine, Reverse

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@article{ca244edaeaf94374861012a89e80921a,

title = "Very early changes in circulating T3 and rT3 during development of metabolic derangement in diabetic patients",

abstract = "Alterations in circulating iodothyronines were studied in 15 juvenile type diabetic patients during the development of metabolic derangement after withdrawal of insulin. By means of measurements of circulating C peptide, one group of patients with and one without residual beta-cell function had been selected. In both groups there was a gradual decrease in serum T3 during the 12-hour period studied after withdrawal of insulin, while an increase in serum rT3 was observed after 4-6 hours. The alterations in serum T3 and the metabolic derangement were significantly more pronounced in patients without than with residual beta-cell function.",

keywords = "C-Peptide, Diabetes Mellitus, Type 1, Humans, Insulin, Islets of Langerhans, Time Factors, Triiodothyronine, Triiodothyronine, Reverse",

author = "S Madsbad and P Laurberg and J Weeke and H Orskov and Faber, {O K} and C Binder and T Krarup and L Regeur",

year = "1981",

language = "English",

volume = "209",

pages = "385--7",

journal = "ACTA MEDICA SCANDINAVICA",

issn = "0001-6101",

publisher = "Almqvist & Wiksell",

number = "5",

}

TY - JOUR

T1 - Very early changes in circulating T3 and rT3 during development of metabolic derangement in diabetic patients

AU - Madsbad, S

AU - Laurberg, P

AU - Weeke, J

AU - Orskov, H

AU - Faber, O K

AU - Binder, C

AU - Krarup, T

AU - Regeur, L

PY - 1981

Y1 - 1981

N2 - Alterations in circulating iodothyronines were studied in 15 juvenile type diabetic patients during the development of metabolic derangement after withdrawal of insulin. By means of measurements of circulating C peptide, one group of patients with and one without residual beta-cell function had been selected. In both groups there was a gradual decrease in serum T3 during the 12-hour period studied after withdrawal of insulin, while an increase in serum rT3 was observed after 4-6 hours. The alterations in serum T3 and the metabolic derangement were significantly more pronounced in patients without than with residual beta-cell function.

AB - Alterations in circulating iodothyronines were studied in 15 juvenile type diabetic patients during the development of metabolic derangement after withdrawal of insulin. By means of measurements of circulating C peptide, one group of patients with and one without residual beta-cell function had been selected. In both groups there was a gradual decrease in serum T3 during the 12-hour period studied after withdrawal of insulin, while an increase in serum rT3 was observed after 4-6 hours. The alterations in serum T3 and the metabolic derangement were significantly more pronounced in patients without than with residual beta-cell function.

KW - C-Peptide

KW - Diabetes Mellitus, Type 1

KW - Humans

KW - Insulin

KW - Islets of Langerhans

KW - Time Factors

KW - Triiodothyronine

KW - Triiodothyronine, Reverse

M3 - Journal article

C2 - 7018180

SN - 0001-6101

VL - 209

SP - 385

EP - 387

JO - ACTA MEDICA SCANDINAVICA

JF - ACTA MEDICA SCANDINAVICA

IS - 5

ER -

Very early changes in circulating T3 and rT3 during development of metabolic derangement in diabetic patients

Abstract

Keywords

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