Whole-genome sequencing of bloodstream Staphylococcus aureus isolates does not distinguish bacteraemia from endocarditis

Berit Lilje, Rasmus Vedby Rasmussen, Anders Dahl, Marc Stegger, Robert Leo Skov, Vance G Fowler, Kim Lee Ng, Kristoffer Kiil, Anders Rhod Larsen, Andreas Petersen, Helle Krogh Johansen, Henrik Carl Schønheyder, Magnus Arpi, Flemming S Rosenvinge, Eva Korup, Ulla Høst, Christian Hassager, Sabine Ute Alice Gill, Thomas Fritz Hansen, Thor Bech JohannesenJesper Smit, Peter Søgaard, Paal Skytt Andersen, Niels Eske-Bruun

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Most Staphylococcus aureus isolates can cause invasive disease given the right circumstances, but it is unknown if some isolates are more likely to cause severe infections than others. S. aureus bloodstream isolates from 120 patients with definite infective endocarditis and 121 with S. aureus bacteraemia without infective endocarditis underwent whole-genome sequencing. Genome-wide association analysis was performed using a variety of bioinformatics approaches including SNP analysis, accessory genome analysis and k-mer based analysis. Core and accessory genome analyses found no association with either of the two clinical groups. In this study, the genome sequences of S. aureus bloodstream isolates did not discriminate between bacteraemia and infective endocarditis. Based on our study and the current literature, it is not convincing that a specific S. aureus genotype is clearly associated to infective endocarditis in patients with S. aureus bacteraemia.

Original languageEnglish
JournalMicrobial Genomics
Issue number11
Publication statusPublished - 2017


  • Journal Article


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