TY - JOUR
T1 - Whole-genome sequencing of bloodstream Staphylococcus aureus isolates does not distinguish bacteraemia from endocarditis
AU - Lilje, Berit
AU - Rasmussen, Rasmus Vedby
AU - Dahl, Anders
AU - Stegger, Marc
AU - Skov, Robert Leo
AU - Fowler, Vance G
AU - Ng, Kim Lee
AU - Kiil, Kristoffer
AU - Larsen, Anders Rhod
AU - Petersen, Andreas
AU - Johansen, Helle Krogh
AU - Schønheyder, Henrik Carl
AU - Arpi, Magnus
AU - Rosenvinge, Flemming S
AU - Korup, Eva
AU - Høst, Ulla
AU - Hassager, Christian
AU - Gill, Sabine Ute Alice
AU - Hansen, Thomas Fritz
AU - Johannesen, Thor Bech
AU - Smit, Jesper
AU - Søgaard, Peter
AU - Skytt Andersen, Paal
AU - Eske-Bruun, Niels
PY - 2017
Y1 - 2017
N2 - Most Staphylococcus aureus isolates can cause invasive disease given the right circumstances, but it is unknown if some isolates are more likely to cause severe infections than others. S. aureus bloodstream isolates from 120 patients with definite infective endocarditis and 121 with S. aureus bacteraemia without infective endocarditis underwent whole-genome sequencing. Genome-wide association analysis was performed using a variety of bioinformatics approaches including SNP analysis, accessory genome analysis and k-mer based analysis. Core and accessory genome analyses found no association with either of the two clinical groups. In this study, the genome sequences of S. aureus bloodstream isolates did not discriminate between bacteraemia and infective endocarditis. Based on our study and the current literature, it is not convincing that a specific S. aureus genotype is clearly associated to infective endocarditis in patients with S. aureus bacteraemia.
AB - Most Staphylococcus aureus isolates can cause invasive disease given the right circumstances, but it is unknown if some isolates are more likely to cause severe infections than others. S. aureus bloodstream isolates from 120 patients with definite infective endocarditis and 121 with S. aureus bacteraemia without infective endocarditis underwent whole-genome sequencing. Genome-wide association analysis was performed using a variety of bioinformatics approaches including SNP analysis, accessory genome analysis and k-mer based analysis. Core and accessory genome analyses found no association with either of the two clinical groups. In this study, the genome sequences of S. aureus bloodstream isolates did not discriminate between bacteraemia and infective endocarditis. Based on our study and the current literature, it is not convincing that a specific S. aureus genotype is clearly associated to infective endocarditis in patients with S. aureus bacteraemia.
KW - Journal Article
U2 - 10.1099/mgen.0.000138
DO - 10.1099/mgen.0.000138
M3 - Journal article
C2 - 29208121
SN - 2057-5858
VL - 3
JO - Microbial Genomics
JF - Microbial Genomics
IS - 11
ER -