TY - JOUR
T1 - Women with chronic and episodic migraine exhibit similar widespread pressure pain sensitivity
AU - Palacios, Maria
AU - Lima Florencio, Lidiane
AU - Natália Ferracini, Gabriela
AU - Barón, Johanna
AU - Guerrero, Ángel L.
AU - Ordás-Bandera, Carlos
AU - Arendt-Nielsen, Lars
AU - Fernández-de-Las-Peñas, César
N1 - © 2016 American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
PY - 2016
Y1 - 2016
N2 - OBJECTIVE: To investigate widespread pressure hyperalgesia in the trigemino-cervical and extra-trigeminal (distant pain-free) regions in women with episodic and chronic migraine.METHODS: Fifty-one women with episodic migraine, 52 women with chronic migraine, and 52 healthy women without headache history were recruited. Pressure pain thresholds (PPT) were bilaterally assessed over the trigeminal area (i.e., temporalis muscle), cervical area (i.e., C5/C6 zygapophyseal joint), and two extra-trigeminal areas (i.e., second metacarpal, tibialis anterior muscle) in a blinded design. Clinical features of migraine and anxiety/depression (Hospital Anxiety and Depression Scale, HADS) were also assessed.RESULTS: The multivariate analysis of covariance (ANCOVA) revealed that PPTs were significantly decreased bilaterally over trigeminal and extra-trigeminal points in migraine patients compared to healthy women (all sites,P < 0.001). No differences between episodic and chronic migraine were observed (all,P > 0.919). The presence of neck pain (all,P > 0.282), anxiety (P > 0.425) or depression (all,P > 0.316) did not influence the results. The intensity of migraine pain was negatively associated with widespread pressure pain sensitivity: The greater the intensity of migraine attacks, the lower the widespread PPT levels, i.e., the greater the widespread sensitization.CONCLUSIONS: This study found similar widespread pressure hypersensitivity in women with episodic or chronic migraine suggesting that central manifestations are involved both in episodic and chronic migraine.
AB - OBJECTIVE: To investigate widespread pressure hyperalgesia in the trigemino-cervical and extra-trigeminal (distant pain-free) regions in women with episodic and chronic migraine.METHODS: Fifty-one women with episodic migraine, 52 women with chronic migraine, and 52 healthy women without headache history were recruited. Pressure pain thresholds (PPT) were bilaterally assessed over the trigeminal area (i.e., temporalis muscle), cervical area (i.e., C5/C6 zygapophyseal joint), and two extra-trigeminal areas (i.e., second metacarpal, tibialis anterior muscle) in a blinded design. Clinical features of migraine and anxiety/depression (Hospital Anxiety and Depression Scale, HADS) were also assessed.RESULTS: The multivariate analysis of covariance (ANCOVA) revealed that PPTs were significantly decreased bilaterally over trigeminal and extra-trigeminal points in migraine patients compared to healthy women (all sites,P < 0.001). No differences between episodic and chronic migraine were observed (all,P > 0.919). The presence of neck pain (all,P > 0.282), anxiety (P > 0.425) or depression (all,P > 0.316) did not influence the results. The intensity of migraine pain was negatively associated with widespread pressure pain sensitivity: The greater the intensity of migraine attacks, the lower the widespread PPT levels, i.e., the greater the widespread sensitization.CONCLUSIONS: This study found similar widespread pressure hypersensitivity in women with episodic or chronic migraine suggesting that central manifestations are involved both in episodic and chronic migraine.
U2 - 10.1093/pm/pnw056
DO - 10.1093/pm/pnw056
M3 - Journal article
C2 - 27084411
SN - 1526-2375
VL - 17
SP - 2127
EP - 2133
JO - Pain Medicine
JF - Pain Medicine
IS - 11
ER -