In vivo enzyme evolution in filamentous fungi

This project involves the exploitation of natural mutation and the high selection pressures which develop in continuous flow culture systems, to obtain enzymes with specific new properties, such as altered substrate specificity or a reduced pH optimum. The project will focus on obtaining altered lipases and phytases from Fusarium venenatum and Aspergillus niger. (Marilyn Wiebe, Budi J. Hidayat, Niels T. Eriksen, Eva I. Petersen)