TY - JOUR
T1 - Diabetes and Abdominal Aortic Calcification
T2 - a Systematic Review
AU - Bendix, Emilie Frey
AU - Johansen, Eskild
AU - Ringgaard, Thomas
AU - Wolder, Martin
AU - Starup-Linde, Jakob
PY - 2018
Y1 - 2018
N2 - PURPOSE OF REVIEW: A systematic literature review was performed to evaluate diabetes mellitus (DM) as a risk factor of abdominal aortic calcification (AAC), and address factors that might contribute to the development of AAC in DM patients.RECENT FINDINGS: DM is an independent risk factor of AAC development. Bone metabolism along with lifestyle factors among DM patients makes them more prone to AAC. Hip and vertebral fractures, high phosphate, smoking, hypertension, and low osteocalcin could make DM patients prone to AAC. Low levels of high-density lipoprotein (HDL), high low-density lipoprotein (LDL), high total cholesterol/HDL ratio, low bone mineral density (BMD) may be risk factors, but the literature is more ambiguous. Body mass index (BMI) does not appear to increase risk of AAC. High phosphate levels and low osteocalcin levels seem to be biomarkers of AAC in patients with diabetes. However, the association between DM and AAC is complicated.
AB - PURPOSE OF REVIEW: A systematic literature review was performed to evaluate diabetes mellitus (DM) as a risk factor of abdominal aortic calcification (AAC), and address factors that might contribute to the development of AAC in DM patients.RECENT FINDINGS: DM is an independent risk factor of AAC development. Bone metabolism along with lifestyle factors among DM patients makes them more prone to AAC. Hip and vertebral fractures, high phosphate, smoking, hypertension, and low osteocalcin could make DM patients prone to AAC. Low levels of high-density lipoprotein (HDL), high low-density lipoprotein (LDL), high total cholesterol/HDL ratio, low bone mineral density (BMD) may be risk factors, but the literature is more ambiguous. Body mass index (BMI) does not appear to increase risk of AAC. High phosphate levels and low osteocalcin levels seem to be biomarkers of AAC in patients with diabetes. However, the association between DM and AAC is complicated.
KW - Abdominal aortic calcification
KW - Bone markers
KW - Diabetes
KW - Extraskeletal calcification
KW - Lifestyle factors
UR - http://www.scopus.com/inward/record.url?scp=85041128204&partnerID=8YFLogxK
U2 - 10.1007/s11914-018-0418-z
DO - 10.1007/s11914-018-0418-z
M3 - Review article
C2 - 29380116
SN - 1544-1873
VL - 16
SP - 42
EP - 57
JO - Current Osteoporosis Reports
JF - Current Osteoporosis Reports
IS - 1
ER -