ECG-Based Measurements of Drug-induced Repolarization Changes

Tanveer Ahmed Bhuiyan

doi:10.5278/vbn.phd.med.00002

ECG-Based Measurements of Drug-induced Repolarization Changes

Tanveer Ahmed Bhuiyan

Research output: PhD thesis

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Abstract

The purpose of this thesis is to investigate the abnormal repolarization both in the cellular and the surface ECG along with their relationship. It has been identified that the certain morphological changes of the monophasic action potential are predictor of TdP arrhythmia. Therefore the proportional changes of the surface ECG which corresponds to the arrhythmia-triggering MAP morphology is warranted to increase the confidence of determining cardiotoxicity of drugs.

Original language	English
Supervisors	Struijk, Johannes Jan, Principal supervisor Graff, Claus, Co-supervisor
Publisher	Aalborg Universitetsforlag
Electronic ISBNs	978-87-7112-358-6
DOIs	https://doi.org/10.5278/vbn.phd.med.00002
Publication status	Published - 2015

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abstract = "The purpose of this thesis is to investigate the abnormal repolarization both in the cellular and the surface ECG along with their relationship. It has been identified that the certain morphological changes of the monophasic action potential are predictor of TdP arrhythmia. Therefore the proportional changes of the surface ECG which corresponds to the arrhythmia-triggering MAP morphology is warranted to increase the confidence of determining cardiotoxicity of drugs. ",

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AB - The purpose of this thesis is to investigate the abnormal repolarization both in the cellular and the surface ECG along with their relationship. It has been identified that the certain morphological changes of the monophasic action potential are predictor of TdP arrhythmia. Therefore the proportional changes of the surface ECG which corresponds to the arrhythmia-triggering MAP morphology is warranted to increase the confidence of determining cardiotoxicity of drugs.

U2 - 10.5278/vbn.phd.med.00002

DO - 10.5278/vbn.phd.med.00002

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PB - Aalborg Universitetsforlag

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ECG-Based Measurements of Drug-induced Repolarization Changes

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