TY - JOUR
T1 - Fracture risk in hepatitis C virus infected persons
T2 - results from the DANVIR cohort study
AU - Eg Hansen, Ann-Brit
AU - Haukali Omland, Lars
AU - Krarup, Henrik
AU - Obel, Niels
AU - on behalf of the DANVIR cohort study
N1 - Copyright © 2014. Published by Elsevier B.V.
PY - 2014
Y1 - 2014
N2 - BACKGROUND AND AIMS: The association between Hepatitis C virus (HCV)-infection and fracture risk is not well characterized. We compared fracture risk between HCV-seropositive (HCV-exposed) patients and the general population and between patients with cleared and chronic HCV-infection.METHODS: Outcome measures were time to first fracture at any site, time to first low-energy and first non low-energy (other) fracture in 12,013 HCV-exposed patients from the DANVIR cohort compared with a general population control cohort (n = 60,065) matched by sex and age. Within DANVIR, 4500 patients with chronic HCV-infection and 2656 patients with cleared HCV-infection were studied.RESULTS: Compared with population controls, HCV-exposed patients had increased overall risk of fracture [adjusted incidence rate ratio (aIRR) 2.15, 95% Confidence Interval (CI) 2.03 - 2.28], increased risk of low-energy fracture (aIRR 2.13, 95% CI 1.93 - 2.35) and of other fracture (aIRR 2.18, 95% CI 2.02 - 2.34). Compared with cleared HCV-infection, chronic HCV-infection was not associated with increased risk of fracture at any site (aIRR 1.08, 95% CI 0.97 - 1.20), or other fracture (aIRR 1.04, 95% CI 0.91 - 1.19). The aIRR for low-energy fracture was 1.20 (95% CI 0.99 - 1.44).CONCLUSIONS: HCV-exposed patients had increased risk of all fracture types. In contrast, overall risk of fracture did not differ between patients with chronic versus cleared HCV-infection, although chronic HCV-infection might be associated with a small excess risk of low-energy fractures. Our study suggests that fracture risk in HCV-infected patients is multi-factorial and mainly determined by lifestyle-related factors associated with HCV-exposure.
AB - BACKGROUND AND AIMS: The association between Hepatitis C virus (HCV)-infection and fracture risk is not well characterized. We compared fracture risk between HCV-seropositive (HCV-exposed) patients and the general population and between patients with cleared and chronic HCV-infection.METHODS: Outcome measures were time to first fracture at any site, time to first low-energy and first non low-energy (other) fracture in 12,013 HCV-exposed patients from the DANVIR cohort compared with a general population control cohort (n = 60,065) matched by sex and age. Within DANVIR, 4500 patients with chronic HCV-infection and 2656 patients with cleared HCV-infection were studied.RESULTS: Compared with population controls, HCV-exposed patients had increased overall risk of fracture [adjusted incidence rate ratio (aIRR) 2.15, 95% Confidence Interval (CI) 2.03 - 2.28], increased risk of low-energy fracture (aIRR 2.13, 95% CI 1.93 - 2.35) and of other fracture (aIRR 2.18, 95% CI 2.02 - 2.34). Compared with cleared HCV-infection, chronic HCV-infection was not associated with increased risk of fracture at any site (aIRR 1.08, 95% CI 0.97 - 1.20), or other fracture (aIRR 1.04, 95% CI 0.91 - 1.19). The aIRR for low-energy fracture was 1.20 (95% CI 0.99 - 1.44).CONCLUSIONS: HCV-exposed patients had increased risk of all fracture types. In contrast, overall risk of fracture did not differ between patients with chronic versus cleared HCV-infection, although chronic HCV-infection might be associated with a small excess risk of low-energy fractures. Our study suggests that fracture risk in HCV-infected patients is multi-factorial and mainly determined by lifestyle-related factors associated with HCV-exposure.
U2 - 10.1016/j.jhep.2014.03.007
DO - 10.1016/j.jhep.2014.03.007
M3 - Journal article
C2 - 24650694
SN - 0168-8278
VL - 61
SP - 15
EP - 21
JO - Journal of Hepatology
JF - Journal of Hepatology
IS - 1
ER -